The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis
Open accessAbstract
Inflammation response plays a critical role in all phases of atherosclerosis (AS). Increased evidence has demonstrated that miR-155 mediates inflammatory mediators in macrophages to promote plaque formation and rupture. However, the precise mechanism of miR-155 remains unclear in AS. Here, we also found that miR-155 and PDCD4 were elevated in the aortic tissue of atherosclerotic mice and ox-LDL treated RAW264.7 cells. Further studies showed that miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-α. Downregulation of miR-155 and PDCD4 and upregulation of SOCS1 obviously decreased the IL-6 and TNF-α expression. In addition, inhibition of miR-155 levels in atherosclerotic mice could notably reduce the IL-6 and TNF-α level in plasma and aortic tissue, accompanied with increased p-STAT3 and PDCD4 and decreased SOCS1. Thus, miR-155 might mediate the inflammation in AS via the SOCS1-STAT3-PDCD4 axis. These results provide a rationale for intervention of intracellular miR-155 as possible antiatherosclerotic targets.
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“Recently, it was shown that PDCD4 is also an important factor for inflammatory diseases such as asthma [86] and atherosclerosis [87,88].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [88]
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Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
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Accumulation of miR-155 and BIC RNA in human B cell lymphomas
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Pervasive roles of microRNAs in cardiovascular biology
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Inflammation in Atherosclerosis: Transition From Theory to Practice
Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
Siveen, K. S., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.005 · Cited by 645
SOCS regulation of the JAK/STAT signalling pathway
Croker, B. A., Kiu, H., & Nicholson, S. E. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.010 · Cited by 633
Ouimet, M., Ediriweera, H. N., Gundra, U. M., Sheedy, F. J., Ramkhelawon, B., Hutchison, S. B., Rinehold, K., van Solingen, C., Fullerton, M. D., Cecchini, K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81676 · Cited by 394
Regulation of the MIR155 host gene in physiological and pathological processes
Elton, T. S., Selemon, H., Elton, S. M., & Parinandi, N. L. (2013) · Gene · doi:10.1016/j.gene.2012.12.009 · Cited by 393
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Macrophage polarization and allergic asthma
Saradna, A., Do, D. C., Kumar, S. A., Fu, Q.-L., & Gao, P. (2017) · Translational research · doi:10.1016/j.trsl.2017.09.002 · Cited by 441
Jain, N., Moeller, J., & Vogel, V. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121224 · Cited by 237
MicroRNAs in the Pathobiology and Therapy of Atherosclerosis
Laffont, B., & Rayner, K. J. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.01.001 · Cited by 153
Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions
Matsuhashi, S., Manirujjaman, M., Hamajima, H., & Ozaki, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092304 · Cited by 143
Yang, L., Sun, J., Liu, Q., Zhu, R., Yang, Q., Hua, J., Zheng, L., Li, K., Wang, S., & Li, A. (2019) · Advanced Science · doi:10.1002/advs.201802012 · Cited by 101
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Metadata
- Authors
- Ye, J., Guo, R., Shi, Y., Qi, F., Guo, C., & Yang, L.
- Affiliations
- Army Medical University (CN)
- Kunming General Hospital of Chengdu Military Command (CN)
- Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan 650032, China
- Corresponding author
- Yang, Lixia
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-14
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC5098093
- OpenAlex
- W2533066341
- Cited by
- 127
- References
- 49
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 11 · 2021: 9 · 2020: 21 · 2019: 18 · 2018: 8 · 2017: 5
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- miR-155, atherosclerosis, atherogenesis, inflammation, SOCS1, STAT3, PDCD4, macrophages, interleukin-6, TNF-α, oxidized LDL, microRNA
- MeSH terms
- RAW 264.7 Cells, Suppressor of Cytokine Signaling 1 Protein, Animals, Aorta, Apolipoproteins E, Inflammation, Male, Tumor Necrosis Factor-alpha, Signal Transduction, RNA-Binding Proteins, RNA, Small Interfering, MicroRNAs, Atherosclerosis, STAT3 Transcription Factor, Apoptosis Regulatory Proteins, Mice
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