CoChat
Sign Up
Cited by 64Diabetes Management and ResearchPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Increased Insulin Sensitivity in Patients with Idiopathic Reactive Hypoglycemia

TAMBURRANO, GUIDO, LEONETTI, FRIDA, SBRACCIA, PAOLO, GIACCARI, ANDREA, LOCURATOLO, NICOLA, LALA, LBERTOA·1989·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-69-4-885
Open this paper in CoChat — free account

Abstract

We performed a euglycemic hyperinsulinemic glucose clamp in 20 patients selected from a large number of subjects referred to our clinic with symptoms suggesting reactive hypoglycemia. Diagnosis was made on the basis of blood glucose measurements during symptoms in their daily life and confirmed by a 5-h oral glucose tolerance test. The patients were divided into the following groups: 8 patients with idiopathic reactive hypoglycemia (IRH), i.e. biochemical hypoglycemia associated with symptoms and plasma insulin concentrations in the normal range; 6 patients with nonhypoglycemia (NH), i.e. patients experiencing the symptoms evoking hypoglycemia at essentially normal plasma glucose levels; and 6 patients with alimentary hypoglycemia secondary to previous gastric surgery (GS). Eight normal volunteers formed the control group (N). Hypoglycemia in this study was considered to be present when plasma glucose concentrations were below 2.5 mmol/L. The peak cortisol levels after glycemic nadir were higher (2P less than 0.05) in IRH compared to GS and N. In the same group, a partially deficient glucagon response to hypoglycemia was noted. During the euglycemic clamp, the glucose uptake appeared to be significantly greater in the IRH group than in NH, GS, and N groups (8.13 +/- 0.49 vs. 7.02 +/- 0.35, 6.48 +/- 0.22, and 6.66 +/- 0.42 mg/kg.min, respectively; 2P less than 0.05). Therefore, our data suggest that increased insulin sensitivity represents a feature of idiopathic reactive hypoglycemia.

Integrity signals

Registry

Crossref · 10.1210/jcem-69-4-885

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increased insulin sensitivity represents a feature of idiopathic reactive hypoglycemia.

    “Tamburrano et al.[29] reported that increased insulin sensitivity represents a feature of idiopathic reactive hypoglycemia.”

    From Postprandial Reactive Hypoglycemia (2019) · cites this paper as [29]

  • Tamburrano et al. found that increased insulin sensitivity is a feature of idiopathic reactive hypoglycemia.

    “On the contrary, Tamburrano et al. [11] performed a euglycemic hyperinsulinemic glucose clamp on 20 patients with symptoms suggesting reactive hypoglycemia, and the results suggested that increased insulin sensitivity represents a feature of idiopathic reactive hypoglycemia.”

    From Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population (2017) · cites this paper as [11]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
TAMBURRANO, G., LEONETTI, F., SBRACCIA, P., GIACCARI, A., LOCURATOLO, N., & LALA, L.
Affiliations
Sapienza University of Rome (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1989-10
Volume
69
Issue
4
Pages
885-890
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-69-4-885
OpenAlex
W2007626235
Cited by
64
References
17
Citations by year
2026: 3 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin sensitivity, glucose uptake, gastric surgery, hyperinsulinemic-euglycemic clamp, hypoglycemic symptoms
MeSH terms
Adult, Blood Glucose, Female, Glucose Tolerance Test, Humans, Hypoglycemia, Insulin, Insulin Infusion Systems, Male, Recombinant Proteins, Reference Values, Glucose Clamp Technique

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review