Ascorbic-acid-induced haemolysis in G-6-PD deficiency
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High-dose intravenous ascorbate caused haemolytic anaemia in patients lacking G6PD.
“Patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency showed haemolytic anaemia following high-dose intravenous ascorbate therapy56–59.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [59]
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Cites
The Hemolytic Effect of Primaquine and Related Compounds: a Review
Beutler, E. (1959) · Blood · doi:10.1182/blood.v14.2.103.103 · Cited by 398 · see citing works
Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency
CAMPBELL, G. D., STEINBERG, M. H., & BOWER, J. D. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-82-6-810_1 · Cited by 134 · see citing works
Winterbourn, C. C. (1979) · British Journal of Haematology · doi:10.1111/j.1365-2141.1979.tb05853.x · Cited by 55 · see citing works
Hemolytic Anemia in Disorders of Red Cell Metabolism.
(1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-1-144_3 · Cited by 47 · see citing works
Udomratn, T., Steinberg, M. H., Campbell, G. J., & Oelshlegel, F. J. (1977) · Blood · doi:10.1182/blood.v49.3.471.471 · Cited by 23 · see citing works
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Vitamin C: The known and the unknown and Goldilocks
Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753 · see citing works
Criteria and recommendations for vitamin C intake
Levine, M. (1999) · JAMA · doi:10.1001/jama.281.15.1415 · Cited by 559 · see citing works
Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?
Halliwell, B. (1996) · Free Radical Research · doi:10.3109/10715769609149066 · Cited by 531 · see citing works
Targeting cancer vulnerabilities with high-dose vitamin C
Ngo, B., Van Riper, J. M., Cantley, L. C., & Yun, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0135-7 · Cited by 423 · see citing works
Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency.
Rees, D. C., Kelsey, H., & Richards, J. D. (1993) · BMJ · doi:10.1136/bmj.306.6881.841 · Cited by 191 · see citing works
Determination of optimal vitamin C requirements in humans
Levine, M., Dhariwal, K., Welch, R., Wang, Y., & Park, J. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1347s · Cited by 149 · see citing works
The health effects of vitamin C supplementation: A review
Bendich, A., & Langseth, L. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718484 · Cited by 150 · see citing works
Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach
Klimant, E., Wright, H., Rubin, D., Seely, D., & Markman, M. (2018) · Current Oncology · doi:10.3747/co.25.3790 · Cited by 99 · see citing works
Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient
Quinn, J., Gerber, B., Fouche, R., Kenyon, K., Blom, Z., & Muthukanagaraj, P. (2017) · Case Reports in Medicine · doi:10.1155/2017/5202606 · Cited by 37 · see citing works
Haemolysis induced by ascorbic acid in paroxysmal nocturnal haemoglobinuria
Iwamoto, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Hidaka, M., Kagimoto, T., Takatsuki, K., & Nakakuma, H. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91195-9 · Cited by 30 · see citing works
- Authors
- Mehta, J., Singhal, S., & Mehta, B.
- Affiliations
- Academisch Ziekenhuis Rotterdam (NL)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1990-10
- Volume
- 336
- Issue
- 8720
- Pages
- 944
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2157154182
- Cited by
- 74
- References
- 5
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- vitamin C, hemolysis, glucose-6-phosphate dehydrogenase deficiency, oxidative hemolysis
- MeSH terms
- Ascorbic Acid, Carbonated Beverages, Child, Glucosephosphate Dehydrogenase Deficiency, Hemolysis, Humans, Male, Time Factors
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