The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Phagocytosis: A Fundamental Process in Immunity
Open accessAbstract
One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was the first to observe the uptake of particles by cells and realized the importance of this process for the host response to injury and infection. He also was a strong advocate of the role of phagocytosis in cellular immunity, and with this he gave us the basis for our modern understanding of inflammation and the innate and acquired immune responses. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation. In recent years, the use of new tools of molecular biology and microscopy has provided new insights into the cellular mechanisms of phagocytosis. In this review, we present a general view of our current knowledge on phagocytosis. We emphasize novel molecular findings, particularly on phagosome formation and maturation, and discuss aspects that remain incompletely understood.
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Cites
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Cited by
Neutrophils at the crossroads of innate and adaptive immunity
Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372
Self-citationAntigen processing and presentation
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.07.005 · Cited by 194
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Selective activation of PFKL suppresses the phagocytic oxidative burst
Amara, N., Cooper, M. P., Voronkova, M. A., Webb, B. A., Lynch, E. M., Kollman, J. M., Ma, T., Yu, K., Lai, Z., Sangaraju, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.004 · Cited by 158
A non-bilaterian perspective on the development and evolution of animal digestive systems
Steinmetz, P. R. H. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03075-x · Cited by 67
Metadata
- Authors
- Rosales, C., & Uribe-Querol, E.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-18
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2625489207
- Cited by
- 552
- References
- 25
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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