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Cited by 270Sulfur Compounds in BiologyAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine

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Bin, Peng, Huang, Ruilin, Zhou, Xihong·2017·BioMed Research International
DOI 10.1155/2017/9584932PMC PMC5763110
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Abstract

Sulfur amino acids are a kind of amino acids which contain sulfhydryl, and they play a crucial role in protein structure, metabolism, immunity, and oxidation. Our review demonstrates the oxidation resistance effect of methionine and cysteine, two of the most representative sulfur amino acids, and their metabolites. Methionine and cysteine are extremely sensitive to almost all forms of reactive oxygen species, which makes them antioxidative. Moreover, methionine and cysteine are precursors of S-adenosylmethionine, hydrogen sulfide, taurine, and glutathione. These products are reported to alleviate oxidant stress induced by various oxidants and protect the tissue from the damage. However, the deficiency and excess of methionine and cysteine in diet affect the normal growth of animals; thereby a new study about defining adequate levels of methionine and cysteine intake is important.

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  • Cysteine residues are major targets of ROS and undergo many posttranslational modifications, leading to functional and structural alterations of proteins.

    “In particular, cysteine residues are major targets of ROS undergoing a large number of posttranslational modifications, leading to functional and structural alterations of proteins.”

    From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [118]

    Section 3 (Cysteine; page unavailable) says cysteine residues are easily oxidized and react with H2O2, supporting their susceptibility to ROS. It does not establish that they are major ROS targets or describe numerous posttranslational modifications leading to functional and structural changes in proteins. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Sulfur-containing amino acids such as cysteine and methionine are highly susceptible to diverse forms of oxidation.

    “Sulfur-containing amino acids, such as cysteine and methionine are highly susceptible to diverse forms of oxidation processes [118,119].”

    From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [118]

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Cited by

Sorted by citations

Authors
Bin, P., Huang, R., & Zhou, X.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
Zhou, Xihong
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-6
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2017/9584932
PMC
PMC5763110
OpenAlex
W2777809930
Cited by
270
References
1
Citations by year
2026: 28 · 2025: 51 · 2024: 40 · 2023: 41 · 2022: 27 · 2021: 36 · 2020: 25 · 2019: 15 · 2018: 6
FWCI
1.26
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (31702125, 31772642, 31330075, 31110103909, 2017NK2322, 2016YFD0500504, 2016YFD0501201, 161343KYSB20160008, 2017JJ3373)
  • Hunan Provincial Science and Technology Department (31702125, 31772642, 31330075, 31110103909, 2017NK2322, 2016YFD0500504, 2016YFD0501201, 161343KYSB20160008, 2017JJ3373)
  • National Key Research and Development Program of China (31702125, 31772642, 31330075, 31110103909, 2017NK2322, 2016YFD0500504, 2016YFD0501201, 161343KYSB20160008, 2017JJ3373)
  • Chinese Academy of Sciences (31702125, 31772642, 31330075, 31110103909, 2017NK2322, 2016YFD0500504, 2016YFD0501201, 161343KYSB20160008, 2017JJ3373)
  • Natural Science Foundation of Hunan Province (31702125, 31772642, 31330075, 31110103909, 2017NK2322, 2016YFD0500504, 2016YFD0501201, 161343KYSB20160008, 2017JJ3373)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
methionine, cysteine, sulfur-containing amino acids, oxidation resistance, reactive oxygen species, oxidative stress, S-adenosylmethionine, hydrogen sulfide, taurine, glutathione, amino acid metabolism, animal growth
MeSH terms
Amino Acids, Sulfur, Antioxidants, Cysteine, Glutathione, Hydrogen Sulfide, Methionine, Oxidation-Reduction, S-Adenosylmethionine, Taurine, Reactive Oxygen Species

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