Cited by 593Folate and B Vitamins ResearchSulfur Compounds in BiologyBiochemical effects in animals

The role of methionine on metabolism, oxidative stress, and diseases

Martínez, Yordan, Li, Xue, Liu, Gang, Bin, Peng, Yan, Wenxin, Más, Dairon, Valdivié, Manuel, Hu, Chien-An Andy +2 more·2017·Amino Acids

Abstract

Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.

Integrity signals

Registry

Crossref · 10.1007/s00726-017-2494-2

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Banana peel has high carbon content and can be used as an absorbent to remove various pollutants from savage water.

    “Banana peel has high carbon content and can be used as an absorbent to remove various pollutants from savage water [24, 25].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Martínez, Y., Li, X., Liu, G., Bin, P., Yan, W., Más, D., Valdivié, M., Hu, C.-A. A., Ren, W., & Yin, Y.
Affiliations
  • Chinese Academy of Sciences (CN)
  • University of New Mexico (US)
  • Hunan Normal University (CN)
Corresponding author
Liu, Gang
Venue
Amino Acids
Published
2017-09-19
Volume
49
Issue
12
Pages
2091-2098
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
OpenAlex
W2754863196
Cited by
583
References
76
Citations by year
2026: 66 · 2025: 93 · 2024: 89 · 2023: 92 · 2022: 80 · 2021: 56 · 2020: 56 · 2019: 32 · 2018: 15 · 2017: 2 · 2012: 1
FWCI
4.63
Type
journal article
Language
en
Open access
closed
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • International Partnership Program of Chinese Academy of Sciences (161343KYSB20160008)
  • National Key Research and Development Program of China (2016YFD0500504)
  • National Natural Science Foundation of China (31570114, 31330075, 31110103909)
  • Chinese Academy of Sciences visiting professorship for senior international scientists (2016VBB007)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
methionine, methionine metabolism, oxidative stress, methionine restriction, transmethylation, homocysteine, MsrA, glutathione synthesis, antioxidant enzymes, lipid metabolism, innate immunity, DNA damage, carcinogenesis, neurodegenerative diseases, cardiovascular disease, neuropsychiatric disorders
MeSH terms
Animals, Cardiovascular Diseases, Humans, Immunity, Innate, Kidney Diseases, Liver Diseases, Methionine, Neoplasms, Nervous System Diseases, Oxidative Stress, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review