The role of methionine on metabolism, oxidative stress, and diseases
Abstract
Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Banana peel has high carbon content and can be used as an absorbent to remove various pollutants from savage water.
“Banana peel has high carbon content and can be used as an absorbent to remove various pollutants from savage water [24, 25].”
From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [24]
Cites
Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
Global cancer statistics, 2012
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21262 · Cited by 26,858 · see citing works
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Nicholson, J. K., Lindon, J. C., & Holmes, E. C. (1999) · Xenobiotica · doi:10.1080/004982599238047 · Cited by 3,903 · see citing works
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works
Free radicals, natural antioxidants, and their reaction mechanisms
Nimse, S. B., & Pal, D. (2015) · RSC Advances · doi:10.1039/c4ra13315c · Cited by 2,084 · see citing works
The Role of Oxidative Stress and Antioxidants in Liver Diseases
Li, S., Tan, H., Wang, N., Zhang, Z.-J., Lao, L., Wong, C.-W., & Feng, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125942 · Cited by 1,837 · see citing works
Amino acids and immune function
Li, P., Yin, Y., Li, D., Kim, S. W., & Wu, G. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450769936x · Cited by 1,588 · see citing works
Self-citationImpaired mitochondrial function in psychiatric disorders
Manji, H. K., Kato, T., Prospero, N. A. D., Ness, S. L., Beal, M. F., Krams, M., & Chen, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3229 · Cited by 478 · see citing works
Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D. (2007) · Amino Acids · doi:10.1007/s00726-006-0477-9 · Cited by 452 · see citing works
Maddocks, O. D. K., Labuschagne, C. F., Adams, P. D., & Vousden, K. H. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.014 · Cited by 440 · see citing works
Patra, R. C., Swarup, D., & Dwivedi, S. K. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00345-6 · Cited by 433 · see citing works
Mitochondria: from cell death executioners to regulators of cell differentiation
Kasahara, A., & Scorrano, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.08.005 · Cited by 420 · see citing works
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399 · see citing works
Acta Veterinaria Et Zootechnica Sinica
Zhang, G., Zhang, Y., Han, J., Guan, W., Li, Y.-K., Xu, B., Zhang, X.-T., & Ma, Y. (2011) · Cited by 363 · see citing works
Important roles for the arginine family of amino acids in swine nutrition and production
Wu, G., Bazer, F. W., Davis, T. A., Jaeger, L. A., Johnson, G. A., Kim, S. W., Knabe, D. A., Meininger, C. J., Spencer, T. E., & Yin, Y. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.07.003 · Cited by 302 · see citing works
Self-citationAntioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View
Yao, J. K., & Keshavan, M. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3603 · Cited by 285 · see citing works
Papakostas, G. I., Shelton, R. C., Zajecka, J. M., Etemad, B., Rickels, K., Clain, A., Baer, L., Dalton, E. D., Sacco, G. R., Schoenfeld, D., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11071114 · Cited by 275 · see citing works
Nutritional metabonomics: applications and perspectives.
Rezzi, S., Ramadan, Z., Fay, L., & Kochhar, S. (2007) · Journal of Proteome Research · doi:10.1021/pr060522z · Cited by 274 · see citing works
Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity
Gonsette, R. E. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.06.029 · Cited by 267 · see citing works
Albers, E. (2009) · IUBMB Life · doi:10.1002/iub.278 · Cited by 236 · see citing works
Oxidative stress and antioxidants in hepatic pathogenesis
Ha, H. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i48.6035 · Cited by 236 · see citing works
Functional Amino Acids and Fatty Acids for Enhancing Production Performance of Sows and Piglets
Kim, S. W., Mateo, R. D., Yin, Y., & Wu, G. (2006) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2007.295 · Cited by 204 · see citing works
Self-citationMitochondria, synaptic plasticity, and schizophrenia.
Ben-Shachar, D., & Laifenfeld, D. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59011-6 · Cited by 193 · see citing works
Enhanced Immune Responses in Broiler Chicks Fed Methionine-Supplemented Diets
Tsiagbe, V. K., COOK, M. E., Harper, A. E., & Sunde, M. (1987) · Poultry Science · doi:10.3382/ps.0661147 · Cited by 182 · see citing works
The atherogenic effect of excess methionine intake
Troen, A. M., Lutgens, E., Smith, D. E., Rosenberg, I. H., & Selhub, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436385100 · Cited by 177 · see citing works
Methionine metabolism in mammals. The methionine-sparing effect of cystine.
Finkelstein, J. D., Martin, J. J., & Harris, B. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37847-5 · Cited by 163 · see citing works
Substrate oxidation by the portal drained viscera of fed piglets
Stoll, B., Burrin, D. G., Henry, J. F., Yu, H., Jahoor, F., & Reeds, P. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e168 · Cited by 160 · see citing works
Swain, B. K., & Johri, T. S. (2000) · British Poultry Science · doi:10.1080/00071660086457 · Cited by 150 · see citing works
Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract
Riedijk, M. A., Stoll, B., Chacko, S. K., Schierbeek, H., Sunehag, A. L., van Goudoever, J. B., & Burrin, D. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607965104 · Cited by 148 · see citing works
Bauchart‐Thevret, C., Stoll, B., Chacko, S. K., & Burrin, D. G. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91021.2008 · Cited by 148 · see citing works
Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway
Campbell, K., Vowinckel, J., Keller, M. A., & Ralser, M. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6516 · Cited by 140 · see citing works
Deng, D., Kang, Y., Chu, W., Li, T., Huang, R., Yin, Y., Liu, Z., Zhang, J., & Wu, G. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.014 · Cited by 137 · see citing works
Self-citationDigestion rate of dietary starch affects systemic circulation of amino acids in weaned pigs
Yin, F., Zhang, Z., Huang, J., & Yin, Y. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993321 · Cited by 136 · see citing works
Self-citationAltered methionine metabolism and transmethylation in cancer.
Hoffman, R. M. (1985) · PubMed · Cited by 106 · see citing works
Methionine restriction on lipid metabolism and its possible mechanisms
Zhou, X., He, L., Wan, D., HuanSheng, Y., Yao, K., Wu, G., Wu, X., & Yin, Y. (2016) · Amino Acids · doi:10.1007/s00726-016-2247-7 · Cited by 101 · see citing works
Self-citationGlutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease
Cassano, T., Serviddio, G., Gaetani, S., Romano, A., Dipasquale, P., Cianci, S., Bellanti, F., Laconca, L., Romano, A. D., Padalino, I., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.021 · Cited by 99 · see citing works
Vieira, S. L., Lemme, A., Goldenberg, D. B., & Brugalli, I. (2004) · Poultry Science · doi:10.1093/ps/83.8.1307 · Cited by 99 · see citing works
Carew, L. B., McMurtry, J. P., & Alster, F. A. (2003) · Poultry Science · doi:10.1093/ps/82.12.1932 · Cited by 91 · see citing works
Berries and oxidative stress markers: an overview of human intervention studies
Bo’, C. D., Martini, D., Porrini, M., Klimis‐Zacas, D. J., & Riso, P. (2015) · Food & Function · doi:10.1039/c5fo00657k · Cited by 87 · see citing works
The Methionine Requirement Is Lower in Neonatal Piglets Fed Parenterally than in Those Fed Enterally
Shoveller, A. K. K., Brunton, J. A., Pencharz, P. B., & Ball, R. O. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1390 · Cited by 87 · see citing works
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway
Pirkov, I., Norbeck, J., Gustafsson, L., & Albers, E. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06552.x · Cited by 83 · see citing works
Traumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology
Dash, P. K., Hergenroeder, G. W., Jeter, C. B., Choi, H. A., Kobori, N., & Moore, A. N. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00036 · Cited by 81 · see citing works
Methionine restriction on oxidative stress and immune response in dss-induced colitis mice
Liu, G., Yu, L., Fang, J. Q., Hu, C. A., Yin, J., Ni, H., Ren, W., Duraipandiyan, V., Chen, S., Al-Dhabi, N. A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17812 · Cited by 81 · see citing works
Self-citationDifferential Dependence on Cysteine from Transsulfuration versus Transport During T Cell Activation
Garg, S. K., Yan, Z., Vitvitsky, V., & Banerjee, R. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3496 · Cited by 80 · see citing works
Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat
Maddineni, S. R., Nichenametla, S. N., Sinha, R., Wilson, R. P., & Richie, J. P. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213477988 · Cited by 79 · see citing works
Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal
Romano, A., Serviddio, G., Calcagnini, S., Villani, R., Giudetti, A. M., Cassano, T., & Gaetani, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.046 · Cited by 77 · see citing works
Xiao, Q., Freedman, N. D., Ren, J., Hollenbeck, A. R., Abnet, C. C., & Park, Y. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.17 · Cited by 77 · see citing works
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia
Kumagai, H., Katoh, S., Hirosawa, K., Kimura, M., Hishida, A., & Ikegaya, N. (2002) · Kidney International · doi:10.1111/j.1523-1755.2002.kid558.x · Cited by 76 · see citing works
In vitro oxidation of essential amino acids by jejunal mucosal cells of growing pigs
Chen, L., Yin, Y., Jobgen, W. S., Jobgen, S. C., Knabe, D. A., Hu, W., & Wu, G. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.01.027 · Cited by 66 · see citing works
Self-citationScola, G., Kim, H. K., Young, L. T., & Andreazza, A. C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.028 · Cited by 66 · see citing works
Dietary starch sources affect net portal appearance of amino acids and glucose in growing pigs
Li, T.-J., Dai, Q.-Z., Yin, Y., Zhang, J., Huang, R., Ruan, Z., Deng, Z., & Xie, M. (2008) · animal · doi:10.1017/s1751731108001614 · Cited by 66 · see citing works
Self-citationFolate nutrition and blood–brain barrier dysfunction
Stover, P. J., Durga, J., & Field, M. S. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.01.006 · Cited by 59 · see citing works
Nutrition and health relevant regulation of intestinal sulfur amino acid metabolism
Fang, Z., Yao, K., Zhang, X., Zhao, S., Sun, Z., Tian, G., Yu, B., Lin, Y., Zhu, B., Jia, G., et al. (2010) · Amino Acids · doi:10.1007/s00726-010-0502-x · Cited by 54 · see citing works
Nutritional and Physiological Functions of Amino Acids in Pigs
Blachier, F., Wu, G., & Yin, Y. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1328-8 · Cited by 54 · see citing works
Self-citationLibao‐Mercado, A. J., Yin, Y., van Eys, J. E., & de Lange, C. F. M. (2006) · Journal of Animal Science · doi:10.2527/2006.8461351x · Cited by 51 · see citing works
Self-citationServiddio, G., Romano, A. D., Cassano, T., Bellanti, F., Altomare, E., & Vendemiale, G. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796904740 · Cited by 45 · see citing works
Wang, W., ChangYou, S., Zhang, J., WanTing, G., Li, Y., Gen, M., Chu, W., Huang, R., Liu, Y., Hou, Y., et al. (2008) · Amino Acids · doi:10.1007/s00726-008-0178-7 · Cited by 45 · see citing works
Self-citationHidiroglou, N., Gilani, G. S., Long, L., Zhao, X., Madère, R., Cockell, K. A., Belonge, B., Ratnayake, W. M. N., & Peace, R. W. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.04.009 · Cited by 45 · see citing works
Freitas, I., Boncompagni, E., Tarantola, E., Gruppi, C., Bertone, V., Ferrigno, A., Milanesi, G., Vaccarone, R., Tira, M. E., & Vairetti, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9307064 · Cited by 37 · see citing works
Biomarkers of Oxidative Stress
Lowe, F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_4 · Cited by 37 · see citing works
Yin, Y., & Tan, B. (2010) · Journal of Food Agriculture & Environment · Cited by 36 · see citing works
Self-citationMetabonomics and its role in amino acid nutrition research
He, Q. (2011) · Frontiers in bioscience · doi:10.2741/3865 · Cited by 33 · see citing works
Costa, M. Z., da Silva, T. M., Flores, N. P., Schmitz, F., Scherer, E. B. D. S., Viau, C. M., Saffi, J., Barschak, A. G., Wyse, Â. T. D. S., Spanevello, R. M., et al. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1777-5 · Cited by 31 · see citing works
Soares, M. S. P., Oliveira, P. S., Debom, G. N., de Mattos, B. D. S., Polachini, C. R. N., Baldissarelli, J., Morsch, V. M., Schetinger, M. R. C., Tavares, R. G., Stefanello, F. M., et al. (2016) · Amino Acids · doi:10.1007/s00726-016-2340-y · Cited by 30 · see citing works
Hypermethioninemia provokes oxidative damage and histological changes in liver of rats
Stefanello, F. M., Matté, C., Pederzolli, C. D., Kolling, J., Mescka, C. P., Lamers, M. L., de Assis, A. M., Perry, M. L. S., dos Santos, M. F., & Dutra‐Filho, C. S. (2009) · Biochimie · doi:10.1016/j.biochi.2009.04.018 · Cited by 30 · see citing works
Clinical, etiological and therapeutic aspects of cerebral folate deficiency
Molero-Luís, M., Serrano, M., O’Callaghan, M. M., Sierra, C., Pérez‐Dueñas, B., García‐Cazorla, À., & Artuch, R. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1055322 · Cited by 29 · see citing works
MacKay, D., Brophy, J. D., McBreairty, L. E., McGowan, R. A., & Bertolo, R. F. P. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.005 · Cited by 29 · see citing works
Nutritional and health functions of carbohydrate for pigs
Yin, Y., Deng, Z., Huang, H., Zhong, H., Hou, Z., Gong, J., & Liu, Q. (2004) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/67623/2004 · Cited by 26 · see citing works
Self-citationCerebral Folate Deficiency Presenting as Adolescent Catatonic Schizophrenia: A Case Report
Ho, A., Michelson, D., Aaen, G. S., & Ashwal, S. (2010) · Journal of Child Neurology · doi:10.1177/0883073809343475 · Cited by 24 · see citing works
An outline of pathways in amino acid metabolism.
D’Mello, J. P. F. (2003) · CABI Publishing eBooks · doi:10.1079/9780851996547.0071 · Cited by 24 · see citing works
Hosseini, S. A., Zaghari, M., Lotfollahian, H., Shivazad, M., & Moravaj, H. (2011) · The Journal of Poultry Science · doi:10.2141/jpsa.011021 · Cited by 21 · see citing works
Stefanello, F. M., Kreutz, F., Scherer, E. B. S., Breier, A. C., Vianna, L. P., Trindade, V. M. T., & Wyse, Â. T. D. S. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.08.004 · Cited by 14 · see citing works
Challenges with using chronic disease endpoints in setting dietary reference intakes
Trumbo, P. R. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00077.x · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Betaine in Inflammation: Mechanistic Aspects and Applications
Zhao, G., He, F., Wu, C., Li, P., Li, N., Deng, J., Zhu, G., Ren, W., & Peng, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01070 · Cited by 479 · see citing works
Self-citationB Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease
Lyon, P. D., Strippoli, V., Fang, B., & Cimmino, L. (2020) · Nutrients · doi:10.3390/nu12092867 · Cited by 450 · see citing works
The Roles of Environmental Factors in Regulation of Oxidative Stress in Plant
Xie, X., He, Z., Chen, N., Tang, Z., Wang, Q., & Cai, Y. (2019) · BioMed Research International · doi:10.1155/2019/9732325 · Cited by 426 · see citing works
Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine
Bin, P., Huang, R., & Zhou, X. (2017) · BioMed Research International · doi:10.1155/2017/9584932 · Cited by 270 · see citing works
Self-citationRole of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review
Zhang, Y., Roh, Y. J., Han, S.-J., Park, I., Lee, H. M., Ok, Y. S., Lee, B. C., & Lee, S.-R. (2020) · Antioxidants · doi:10.3390/antiox9050383 · Cited by 267 · see citing works
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
Mahmoud, A. M., & Ali, M. M. (2019) · Nutrients · doi:10.3390/nu11030608 · Cited by 249 · see citing works
Functions and Signaling Pathways of Amino Acids in Intestinal Inflammation
He, F., Wu, C., Li, P., Li, N., Zhang, D., Zhu, Q., Ren, W., & Peng, Y. (2018) · BioMed Research International · doi:10.1155/2018/9171905 · Cited by 209 · see citing works
Self-citationDietary Protein and Muscle Mass: Translating Science to Application and Health Benefit
Carbone, J. W., & Pasiakos, S. M. (2019) · Nutrients · doi:10.3390/nu11051136 · Cited by 210 · see citing works
Methionine Restriction and Cancer Biology
Wanders, D., Hobson, K., & Ji, X. (2020) · Nutrients · doi:10.3390/nu12030684 · Cited by 185 · see citing works
Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity
Chen, L., Collij, V., Jaeger, M., van den Munckhof, I., Vila, A. V., Kurilshikov, A., Gaćeša, R., Sinha, T., Oosting, M., Joosten, L. A. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17840-y · Cited by 154 · see citing works
Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer
Deblois, G., Tonekaboni, S. A. M., Grillo, G., Martínez, C., Kao, Y. I., Tai, F., Ettayebi, I., Fortier, A.-M., Savage, P., Fedor, A. N., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1493 · Cited by 152 · see citing works
Li, Z., Wang, F., Liang, B., Su, Y., Sun, S., Xia, S., Shao, J., Zhang, Z., Hong, M., Zhang, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00349-7 · Cited by 144 · see citing works
Sensing and Signaling of Methionine Metabolism
Lauinger, L., & Kaiser, P. (2021) · Metabolites · doi:10.3390/metabo11020083 · Cited by 128 · see citing works
Cui, C., Han, Y., Li, H., Yu, H., Zhang, B., & Li, G. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.887407 · Cited by 110 · see citing works
Exploratory metabolomics of metabolic syndrome: A status report
Lent-Schochet, D., McLaughlin, M. J., Ramakrishnan, N., & Jialal, I. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v10.i1.23 · Cited by 105 · see citing works
Role of Sulfur Compounds in Vegetable and Mushroom Aroma
Marcinkowska, M. A., & Jeleń, H. H. (2022) · Molecules · doi:10.3390/molecules27186116 · Cited by 104 · see citing works
Antioxidants in Poultry Nutrition and Reproduction: An Update
Surai, P. F. (2020) · Antioxidants · doi:10.3390/antiox9020105 · Cited by 98 · see citing works
Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps
Liang, S., Mao, Y. K., Liao, M., Xu, Y., Chen, Y.-C., Huang, X., Wei, C., Wu, C., Wang, Q., Pan, X., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37399 · Cited by 96 · see citing works
Role of homocysteine in the development and progression of Parkinson’s disease
Fan, X., Zhang, L., Li, H., Chen, G., Qi, G., Ma, X., & Jin, Y. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51227 · Cited by 97 · see citing works
Extreme summers impact cropland and grassland soil microbiomes
Bei, Q., Reitz, T., Schnabel, B., Eisenhauer, N., Schädler, M., Buscot, F., & Heintz‐Buschart, A. (2023) · The ISME Journal · doi:10.1038/s41396-023-01470-5 · Cited by 94 · see citing works
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87 · see citing works
ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions
Chen, Y.-S., Tian, H., Rong, D., Wang, L., Chen, S., Zeng, J., Xu, H., Mei, J., Wang, L.-Y., Liou, Y., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00338-8 · Cited by 87 · see citing works
PHGDH: a novel therapeutic target in cancer
Lee, C. M., Hwang, Y., Kim, M., Park, Y.-C., Kim, H., & Fang, S. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01268-1 · Cited by 81 · see citing works
Wang, Z., Liang, M., Li, H., Cai, L., He, H., Wu, Q., & Yang, L. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9757 · Cited by 79 · see citing works
Li, Z., Hong, T., Shen, G., Gu, Y., Guo, Y., & Han, J. (2022) · Nutrients · doi:10.3390/nu14193887 · Cited by 76 · see citing works
Saoi, M., Li, A., McGlory, C., Stokes, T., von Allmen, M., Phillips, S. M., & Britz‐McKibbin, P. (2019) · Metabolites · doi:10.3390/metabo9070134 · Cited by 75 · see citing works
Feng, L., Li, Q., Zhou, D., Jia, M., Liu, Z., Hou, Z., Ren, Q., Ji, S., Sang, S., Lu, S., et al. (2023) · The Plant Journal · doi:10.1111/tpj.16489 · Cited by 75 · see citing works
Gao, Z., Wang, X., Tan, C., Zhou, H., Mai, K., & He, G. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.08.053 · Cited by 75 · see citing works
Sulfur Metabolism Under Stress
Miller, C. G., & Schmidt, E. E. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8151 · Cited by 74 · see citing works
The Role of Advanced Glycation End Products and Its Soluble Receptor in Kidney Diseases
Steenbeke, M., Speeckaert, R., Desmedt, S., Glorieux, G., Delanghe, J., & Speeckaert, M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073439 · Cited by 73 · see citing works
Catanesi, M., Brandolini, L., d’Angelo, M., Benedetti, E., Tupone, M. G., Alfonsetti, M., Cabri, E., Iaconis, D., Fratelli, M., Cimini, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10091467 · Cited by 70 · see citing works
Machado, M., Azeredo, R., Fontinha, F., Fernández-Boo, S., Conceição, L. E. C., Dias, J. P., & Costas, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02672 · Cited by 70 · see citing works
Wang, K., Khoramjoo, M., Srinivasan, K. K., Gordon, P. M. K., Mandal, R., Jackson, D., Sligl, W., Grant, M. B., Penninger, J. M., Borchers, C. H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101254 · Cited by 69 · see citing works
Sensing of L-methionine in biological samples through fully 3D-printed electrodes
Kalinke, C., Neumsteir, N. V., de Oliveira, P. R., Janegitz, B. C., & Bonacin, J. A. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.10.034 · Cited by 65 · see citing works
Methionine restriction - Association with redox homeostasis and implications on aging and diseases
Zhang, Y., Jelleschitz, J., Grune, T., Chen, W., Zhao, Y., Jia, M., Wang, Y., Liu, Z., & Höhn, A. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102464 · Cited by 69 · see citing works
Li, Z., Liang, D., Ye, D., Chang, H. H., Ziegler, T. R., Jones, D. P., & Ebelt, S. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110506 · Cited by 63 · see citing works
Wang, L., Gao, C. Y., Wang, B., Wang, C., Sagada, G., & Yan, Y. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739310 · Cited by 64 · see citing works
Fang, M., Lei, Z., Ma, R., Jing, W., & Du, L. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115607 · Cited by 61 · see citing works
Li, J., Xu, W., Lai, W., Kong, A., Zhang, Z., Pang, Y., Wang, Z., Shentu, J., Wu, X., Mai, K., et al. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736388 · Cited by 63 · see citing works
Lett, J. A., Sundareswari, M., Ravichandran, K., Bavanilatha, M., Sagadevan, S., & Johan, M. R. (2019) · RSC Advances · doi:10.1039/c9ra00051h · Cited by 62 · see citing works
Epigenetics of Hepatic Insulin Resistance
Maude, H., Sanchez-Cabanillas, C., & Cebola, I. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.681356 · Cited by 60 · see citing works
Genetics and genomics of reproductive disorders in Canadian Holstein cattle
Guarini, A. R., Lourenco, D. A. L., Brito, L. F., Sargolzaei, M., Baes, C. F., Miglior, F., Misztal, I., & Schenkel, F. S. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15038 · Cited by 60 · see citing works
Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins
Yang, J., Hou, L., Wang, J., Xiao, L., Zhang, J., Yin, N., Yao, S., Cheng, K., Zhang, W., Shi, Z., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-326482 · Cited by 59 · see citing works
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Vlase, L., & Popa, D. (2018) · Food & Function · doi:10.1039/c7fo01967j · Cited by 59 · see citing works
Metabolic Regulation of Methionine Restriction in Diabetes
Yin, J., Ren, W., Chen, S., Li, Y., Han, H. L., Gao, J., Liu, G., Wu, X., Li, Y., Kim, S. W., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700951 · Cited by 58 · see citing works
Self-citationFrailty in Aging and the Search for the Optimal Biomarker: A Review
Sepúlveda, M., Arauna, D., García‐García, F. J., Cecilia Albala, B., Palomo, I. F., & Eduardo Fuentes, Q. (2022) · Biomedicines · doi:10.3390/biomedicines10061426 · Cited by 57 · see citing works
Mecocci, S., Gevi, F., Pietrucci, D., Cavinato, L., Luly, F. R., Pascucci, L., Petrini, S., Ascenzioni, F., Zolla, L., Chillemi, G., et al. (2020) · Nutrients · doi:10.3390/nu12102908 · Cited by 53 · see citing works
Lugata, J. K., Ortega, A. D. S. V., & Szabó, C. (2022) · Agriculture · doi:10.3390/agriculture12101701 · Cited by 54 · see citing works
Yao, Y., Lei, X., Wang, Y., Zhang, G., Huang, H., Zhao, Y., Shi, S., Gao, Y., Cai, X., Gao, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04462 · Cited by 54 · see citing works
Metabolomic Biomarkers for Detection, Prognosis and Identifying Recurrence in Endometrial Cancer
Njoku, K., Sutton, C. J. J., Whetton, A. D., & Crosbie, E. J. (2020) · Metabolites · doi:10.3390/metabo10080314 · Cited by 53 · see citing works
Valdivié-Navarro, M., Martínez, Y., Mesa-Fleitas, O., Botello-León, A., Hurtado, C. B., & Velázquez-Martí, B. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114338 · Cited by 52 · see citing works
Self-citationMiao, Z. Q., Dong, Y., Qin, X., Yuan, J., Han, M., Zhang, K. K., Shi, S., Song, X., Zhang, J., & Li, J. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101231 · Cited by 51 · see citing works
Ji, K., Liang, H., Ren, M., Ge, X., Mi, H., Pan, L., & Yu, H. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.07.005 · Cited by 50 · see citing works
Pei, X.-D., Xiao, J., Wei, G., Zhang, Y., Feng, L., Xiong, Z., Lu, L., Wang, X., Pang, G., Jiang, Y., et al. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.09.021 · Cited by 49 · see citing works
Prince, N., Begum, S., Mínguez‐Alarcón, L., Génard-Walton, M., Huang, M., Soeteman, D. I., Wheelock, C. E., Litonjua, A. A., Weiss, S. T., Kelly, R. S., et al. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138228 · Cited by 48 · see citing works
Mohammed, A. K., Alghetaa, H., Miranda, K., Wilson, K. M., Singh, N. P., Cai, G., Putluri, N., Nagarkatti, P. S., & Nagarkatti, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176244 · Cited by 48 · see citing works
Day-night and seasonal variation of human gene expression across tissues
Wucher, V., Sodaei, R., Amador, R., Irimia, M., & Guigó, R. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001986 · Cited by 47 · see citing works
Microbial production of L-methionine and its precursors using systems metabolic engineering
Cai, M., Liu, Z., Zhao, Z., Wu, H., Xu, M., & Rao, Z. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108260 · Cited by 46 · see citing works
Wang, H., Zhang, H., & Su, Y. (2022) · Animals · doi:10.3390/ani12131677 · Cited by 46 · see citing works
Kumar, R. S., Singh, U., Tiwari, A., Tiwari, P., Sahu, J. K., & Sharma, S. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.02.002 · Cited by 45 · see citing works
Metabolomic Profile of Oviductal Extracellular Vesicles across the Estrous Cycle in Cattle
Gatien, J., Mermillod, P., Tsikis, G., Bernardi, O., Idrissi, S. J., Uzbekov, R. E., Bourhis, D. L., Salvetti, P., Almiñana, C., & Saint‐Dizier, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246339 · Cited by 45 · see citing works
Li, X., Mu, W., Wu, X., Dong, Y., Zhou, Z., Wang, X., Ma, L., Ye, B., & Geng, L. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735014 · Cited by 45 · see citing works
Self-citationJiang, Z., Su, W., Li, W., Wen, C., Du, S., He, H., Zhang, Y., Gong, T., Wang, X., Wang, Y., et al. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.09.006 · Cited by 44 · see citing works
Khan, M. Z., Liu, S., Ma, Y., Ma, M., Ullah, Q., Khan, I. M., Wang, J., Xiao, J., Chen, T., Khan, A. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042895 · Cited by 43 · see citing works
Matthiesen, I., Voulgaris, D., Nikolakopoulou, P., Winkler, T. E., & Herland, A. (2021) · Small · doi:10.1002/smll.202101785 · Cited by 43 · see citing works
Zheng, Z., Liu, L., Zhou, K., Ding, L., Zeng, J., & Zhang, W. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s255392 · Cited by 42 · see citing works
Sulfur-Containing Amino Acids, Hydrogen Sulfide, and Sulfur Compounds on Kidney Health and Disease
Chen, C., Cheng, M., Hsu, C., & Tain, Y. (2023) · Metabolites · doi:10.3390/metabo13060688 · Cited by 41 · see citing works
Application of nutrition interventions strategy to enhance fish flesh quality
Yu, Z., & Li, M. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.107010 · Cited by 41 · see citing works
Ahmed, M., Liang, H., Kasiya, H. C., Ji, K., Ge, X., Ren, M., Liu, B., Zhu, X., & Sun, A. (2018) · Aquaculture Nutrition · doi:10.1111/anu.12844 · Cited by 41 · see citing works
Agostini, A., Ding, Y., Bai, L., Kendall, D. A., & Pardon, M. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.019 · Cited by 41 · see citing works
Cephalosporin C biosynthesis and fermentation in Acremonium chrysogenum
Liu, L., Chen, Z., Liu, W., Ke, X., Tian, X., & Chu, J. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12181-w · Cited by 39 · see citing works
Enzymes in Metabolic Anticancer Therapy
Maggi, M., & Scotti, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7709-9_9 · Cited by 39 · see citing works
Xu, J., Xl, W., Zeng, H., & Han, Z. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114889 · Cited by 38 · see citing works
Wang, Y., Shen, M., Xu, G., Yu, H., Jia, C., Zhu, F., Meng, Q., Xu, D., Du, S., Zhang, D., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172318 · Cited by 38 · see citing works
Zhou, Y., Li, M., Song, J., Shi, Y., Qin, X., Gao, Z., Lv, Y., & Du, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-74246-y · Cited by 38 · see citing works
Huang, Y., Tu, M., Qian, Y., Ma, J., Chen, L., Liu, Y., Wu, Y., Chen, K., Liu, J., Ying, Y., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.818888 · Cited by 38 · see citing works
Wang, M., Huang, H., Liu, S., Zhuang, Y., Yang, H., Li, Y., Chen, S., Wang, L., Yin, L., Yao, Y., et al. (2019) · RSC Advances · doi:10.1039/c9ra04943f · Cited by 37 · see citing works
Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes
Castellano, F., & Molinier‐Frenkel, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613416 · Cited by 37 · see citing works
Proximate composition, amino acid composition and food product application of anchovy: a review
Kari, N. M., Ahmad, F., & Ayub, M. N. A. (2022) · Food Research · doi:10.26656/fr.2017.6(4).419 · Cited by 37 · see citing works
The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review
Liu, G., & Kim, W. K. (2023) · Animals · doi:10.3390/ani13182949 · Cited by 36 · see citing works
Self-citationLangi, S., Maulu, S., Hasimuna, O. J., Kapula, V. K., & Tjipute, M. (2024) · Cogent Food & Agriculture · doi:10.1080/23311932.2024.2302642 · Cited by 36 · see citing works
Wang, Y., Yin, X., Yin, D., Lei, Z., Mahmood, T., & Yuan, J. (2019) · Animal nutrition · doi:10.1016/j.aninu.2019.06.007 · Cited by 36 · see citing works
Michel, M., Dubowy, K., Entenmann, A., Karall, D., Adam, M. G., Zlamy, M., Komazec, I. O., Geiger, R., Niederwanger, C., Salvador, C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65852-x · Cited by 36 · see citing works
Wahid, M., Saqib, F., Chicea, L. M., Ahmedah, H. T., Sajer, B. H., Marc, R. A., Pop, O. L., Moga, M., & Gavris, C. M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112704 · Cited by 36 · see citing works
RetractedMetabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis
Tang, Y., Shah, S. J., Cho, K., Sun, X., & Chen, D. F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.835736 · Cited by 36 · see citing works
Homocysteine and Parkinson's disease
Zhou, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14420 · Cited by 35 · see citing works
Górny, M., Bilska‐Wilkosz, A., Iciek, M., Hereta, M., Kamińska, K., Kamińska, A., Chwatko, G., Rogóż, Z., & Lorenc‐Koci, E. (2020) · Antioxidants · doi:10.3390/antiox9060538 · Cited by 35 · see citing works
Huang, B., Khan, M. Z., Kou, X., Chen, Y., Liang, H., Ullah, Q., Khan, N., Khan, A. A., Chai, W., & Wang, C. (2023) · Metabolites · doi:10.3390/metabo13101080 · Cited by 34 · see citing works
Guo, T.-Y., Zhao, W., He, J., Liao, S., Xie, J.-J., Xie, S., Masagounder, K., Liu, Y., Tian, L., & Niu, J. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519002289 · Cited by 33 · see citing works
Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans
Polvoy, I., Seo, Y., Parker, M. F. L., Stewart, M. N., Siddiqua, K., Manacsa, H. S., Ravanfar, V., Blecha, J. E., Hope, T. A., VanBrocklin, H. F., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05858-x · Cited by 32 · see citing works
Socha, M. W., Flis, W., & Wartęga, M. (2024) · Nutrients · doi:10.3390/nu16050678 · Cited by 32 · see citing works
Yu, H., Ren, Y., Wei, H., Xing, W., Xu, G., Li, T., Xue, M., & Luo, L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737290 · Cited by 31 · see citing works
Persistent metabolomic alterations characterize chronic critical illness after severe trauma
Horn, D. L., Bettcher, L., Navarro, S. L., Pascua, V., Neto, F. C., Cuschieri, J., Raftery, D., & O’Keefe, G. E. (2020) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000002952 · Cited by 32 · see citing works
Ji, K., Liang, H., Ge, X., Ren, M., Pan, L., & Huang, D. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738125 · Cited by 31 · see citing works
Nutritional Strategies to Alleviate Stress and Improve Welfare in Dairy Ruminants
Kotsampasi, B., Karatzia, M.-A., Tsiokos, D., & Chadio, S. E. (2024) · Animals · doi:10.3390/ani14172573 · Cited by 30 · see citing works
Fang, D., Xu, T., Li, F., Sun, Y., Sun, J., Yin, Y., Zhang, H., Wang, Z., & Liu, Y. (2025) · Nature Communications · doi:10.1038/s41467-024-55791-w · Cited by 30 · see citing works
Self-citationQuantifying methionine requirement of juvenile African catfish (Clarias gariepinus)
Elesho, F. E., Sutter, D. A. H., Swinkels, M. A. C., Verreth, J. A. J., Kröckel, S., & Schrama, J. W. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.736020 · Cited by 30 · see citing works
Guo, Y., Wang, Z. Y., Wang, Y. S., Chen, B., Huang, Y., Li, P., Tan, Q., Zhang, H., & Chen, W. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101661 · Cited by 30 · see citing works
Thermotolerant Soil Microbes and Their Role in Mitigation of Heat Stress in Plants
Maitra, S., Pramanick, B., Dey, P., Bhadra, P., Shankar, T., & Anand, K. (2021) · Sustainable development and biodiversity · doi:10.1007/978-3-030-73507-4_8 · Cited by 29 · see citing works
Deuterium Metabolic Imaging—Rediscovery of a Spectroscopic Tool
Polvoy, I., Qin, H., Flavell, R. R., Gordon, J. W., Viswanath, P., Sriram, R., Ohliger, M. A., & Wilson, D. M. (2021) · Metabolites · doi:10.3390/metabo11090570 · Cited by 29 · see citing works
- Authors
- Martínez, Y., Li, X., Liu, G., Bin, P., Yan, W., Más, D., Valdivié, M., Hu, C.-A. A., Ren, W., & Yin, Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- University of New Mexico (US)
- Hunan Normal University (CN)
- Corresponding author
- Liu, Gang
- Venue
- Amino Acids
- Published
- 2017-09-19
- Volume
- 49
- Issue
- 12
- Pages
- 2091-2098
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W2754863196
- Cited by
- 583
- References
- 76
- Citations by year
- 2026: 66 · 2025: 93 · 2024: 89 · 2023: 92 · 2022: 80 · 2021: 56 · 2020: 56 · 2019: 32 · 2018: 15 · 2017: 2 · 2012: 1
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Partnership Program of Chinese Academy of Sciences (161343KYSB20160008)
- National Key Research and Development Program of China (2016YFD0500504)
- National Natural Science Foundation of China (31570114, 31330075, 31110103909)
- Chinese Academy of Sciences visiting professorship for senior international scientists (2016VBB007)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- methionine, methionine metabolism, oxidative stress, methionine restriction, transmethylation, homocysteine, MsrA, glutathione synthesis, antioxidant enzymes, lipid metabolism, innate immunity, DNA damage, carcinogenesis, neurodegenerative diseases, cardiovascular disease, neuropsychiatric disorders
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Immunity, Innate, Kidney Diseases, Liver Diseases, Methionine, Neoplasms, Nervous System Diseases, Oxidative Stress, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review