Use of Flavonoids and Cinnamates, the Main Photoprotectors with Natural Origin
Open accessAbstract
Many pathological problems are initiated by ultraviolet radiation (UVR), such as skin cancer, the most commonly diagnosed cancer worldwide. The UVA (320–400 nm) and UVB (290–320 nm) wavelengths may cause effects such as photoaging, DNA damage, and a series of cellular alterations. The UVA radiation can damage the DNA, oxidize the lipids, and produce dangerous free radicals, which can cause inflammation, modify the gene expression in response to stress, and weaken the skin immune response. With a minor penetration, the UVB radiation is more harmful, being responsible for immediate damage. Ultraviolet radiation light emitted by the sun is considered necessary for the existence of life but cause radiation problems, especially in the skin. The photoprotective activities of plant extracts and isolated composts were evaluated by many reports, as well as the correlation of these compounds with the antioxidant activity. This review presents plant compounds with interest to the cosmetic industry to be used in sunscreens such as flavonoids and cinnamates.
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Common secondary plant compounds used as alternative photoprotectants include carotenoids, polyphenols, natural botanicals agents, phytochemicals, antioxidants, alkaloids and phenolic compounds.
“Common secondary plant compounds used as alternative photoprotectants include carotenoids, polyphenols, natural botanicals agents, phytochemicals, antioxidants, alkaloids and phenolic compounds as illustrated in Fig .5 (Nunes et al. 2018;Fardiyah et al. 2020;Bendjedid et al. 2021).”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Nunes et al. 2018
Section 4 identifies polyphenols, alkaloids, flavonoids and phenolic acids as plant metabolites with photoprotective potential, and discusses antioxidant plant extracts. It does not identify carotenoids as photoprotectants or establish the entire list as common secondary plant compounds; “botanical agents” and “phytochemicals” are broader descriptions rather than specific compound classes. (LLM, conf=0.87)
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- Authors
- Nunes, A. R., Vieira, Í. G. P., Queiroz, D. B., Leal, A. L. A. B., Maia Morais, S., Muniz, D. F., Calixto-Junior, J. T., & Coutinho, H. D. M.
- Affiliations
- Universidade Estadual do Ceará (BR)
- Biotechnology Doctorate of the Northeastern Biotechnology Network, State University of Ceará, Av. Dr. Silas Munguba 1700, CEP 60714-903, Campus do Itaperi, Fortaleza, Ceará, Brazil
- Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri, Av. Cel. Antonio Luiz, 1161, CEP 63105-000, Pimenta, Crato, Ceará, Brazil
- Universidade Regional do Cariri (BR)
- Corresponding author
- Coutinho, Henrique Douglas Melo
- ORCID
- Venue
- Advances in Pharmacological Sciences
- Publisher
- Wiley
- Published
- 2018-11-28
- Volume
- 2018
- Pages
- 1-9
- ISSN
- 1687-6334 (ISSN-L)
- 1687-6342
- PMC
- PMC6304211
- OpenAlex
- W2902733903
- Cited by
- 90
- References
- 28
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 16 · 2023: 18 · 2022: 8 · 2021: 16 · 2020: 10 · 2019: 6
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Advances in Pharmacological Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- flavonoids, cinnamic acid derivatives, photoprotection, ultraviolet radiation, skin cancer, sunscreen ingredients, plant extracts, antioxidant activity, UVA, UV-B radiation, photoaging, DNA damage, free radicals, cosmetic ingredients
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