Cited by 55Acupuncture Treatment Research StudiesTraditional Chinese Medicine StudiesHealthcare and Venom Research

Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases.

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Lai, Hsiang-Chun, Chang, Qwang-Yuen, Hsieh, Ching-Liang·2019·Evidence-based Complementary and Alternative Medicine

Abstract

In this article, we review signal transduction pathways through which acupuncture treats nervous system diseases. We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer’s disease, dementia, vascular dementia, and Parkinson’s disease. Acupuncture treats nervous system diseases by increasing the brain-derived neurotrophic factor level and involves multiple signal pathways, including p38 MAPKs, Raf/MAPK/ERK 1/2, TLR4/ERK, PI3K/AKT, AC/cAMP/PKA, ASK1-JNK/p38, and downstream CREB, JNK, m-TOR, NF-κB, and Bcl-2/Bax balance. Acupuncture affects synaptic plasticity, causes an increase in neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the blood-brain barrier.

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Authors
Lai, H.-C., Chang, Q.-Y., & Hsieh, C.-L.
Affiliations
  • China Medical University Hospital (TW)
  • Department of Family Medicine, Lin Shin Hospital, Taichung 408, Taiwan
  • China Medical University (TW)
Corresponding author
Hsieh, Ching-Liang
Venue
Evidence-based Complementary and Alternative Medicine
Publisher
Wiley
Published
2019-07-11
Volume
2019
Pages
1-37
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
OpenAlex
W2958707998
Cited by
55
References
194
Citations by year
2026: 7 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 1
FWCI
1.13
Type
journal article
Language
en
Open access
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Ministry of Education (CMRC-CENTER-0, DMR-108-176)
  • China Medical University Hospital (CMRC-CENTER-0, DMR-108-176)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
  • Health Sciences › Medicine › Pharmacology › Healthcare and Venom Research
Keywords
acupuncture, signaling pathways, neurological disorders, brain-derived neurotrophic factor, p38 MAPK, PI3K/Akt, CREB, NF-κB, Bcl-2/Bax, synaptic plasticity, neuroprotection, apoptosis inhibition, anti-inflammation, antioxidant activity, blood-brain barrier, stroke, epilepsy, depression, Alzheimer's disease, Parkinson's disease, ischemic brain injury

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