Mesenchymal stem cell-based therapy of inflammatory lung diseases: current understanding and future perspectives
Open accessAbstract
During acute or chronic lung injury, inappropriate immune response and/or aberrant repair process causes irreversible damage in lung tissue and most usually results in the development of fibrosis followed by decline in lung function. Inhaled corticosteroids and other anti-inflammatory drugs are very effective in patients with inflammatory lung disorders, but their long-term use is associated with severe side effects. Accordingly, new therapeutic agents that will attenuate ongoing inflammation and, at the same time, promote regeneration of injured alveolar epithelial cells are urgently needed. Mesenchymal stem cells (MSCs) are able to modulate proliferation, activation, and effector function of all immune cells that play an important role in the pathogenesis of acute and chronic inflammatory lung diseases. In addition to the suppression of lung-infiltrated immune cells, MSCs have potential to differentiate into alveolar epithelial cells in vitro and, accordingly, represent new players in cell-based therapy of inflammatory lung disorders. In this review article, we described molecular mechanisms involved in MSC-based therapy of acute and chronic pulmonary diseases and emphasized current knowledge and future perspectives related to the therapeutic application of MSCs in patients suffering from acute respiratory distress syndrome, pneumonia, asthma, chronic obstructive pulmonary diseases, and idiopathic pulmonary fibrosis.
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Several studies reported that MSC-derived exosomes efficiently suppressed detrimental immune response in inflamed tissues, and promoted the survival and regeneration of injured cells.
“Several studies reported that MSC-derived exosomes efficiently suppressed detrimental immune response in inflamed tissues, and promoted the survival and regeneration of injured cells [[73], [74], [75]].”
From Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration. (2022) · cites this paper as [73]
Section 7 (page unavailable) reports that MSC-derived exosomes attenuated lung inflammation and enhanced endogenous lung repair, supporting the immune-response and regeneration portions of the claim. It does not report that exosomes promoted the survival of injured cells; Section 8 discusses survival of transplanted MSCs instead. (LLM, conf=0.86)
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- Authors
- Harrell, C. R., Sadikot, R., Pascual, J., Fellabaum, C., Jankovic, M. G., Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V.
- Affiliations
- Regenerative Processing Plant, LLC, 34176 UD Highway 19 N Palm Harbor, Palm Harbor, Florida, USA
- Emory University (US)
- Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Serbia
- Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, Kragujevac, Serbia
- University of Bern (CH)
- West Pasco Pulmonary Associates, 7545 Medical Dr, Hudson, Florida, USA
- Institute of Anatomy, University of Bern, 2 Baltzerstrasse, Switzerland
- ORCID
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2019-05-02
- Volume
- 2019
- Pages
- 1-14
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- PMC
- PMC6525794
- OpenAlex
- W2943233832
- Cited by
- 193
- References
- 126
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 18 · 2023: 22 · 2022: 37 · 2021: 58 · 2020: 34 · 2019: 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cells International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open Access CRIS of the University of Bern
- Funders
- University of Kragujevac (MP01/18, ON175103, ON175069, 16C197)
- Serbian Ministry of Science (MP01/18, ON175103, ON175069, 16C197)
- Novartis Foundation (MP01/18, ON175103, ON175069, 16C197)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- mesenchymal stem cells, cell therapy, inflammatory lung disease, pulmonary fibrosis, acute respiratory distress syndrome, pneumonia, asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, immunomodulation, lung injury
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