The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals
Open accessAbstract
Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations, activating oncogenes, and raising oxidative stress, which all influence cell proliferation, survival, and apoptosis. Cancer cells display redox imbalance due to increased ROS level compared to normal cells. This unique feature in cancer cells may, therefore, be exploited for targeted therapy. Over the past few decades, natural compounds have attracted attention as potential cancer therapies because of their ability to maintain cellular redox homeostasis with minimal toxicity. Preclinical studies show that bioactive dietary polyphenols exert antitumor effects by inducing ROS-mediated cytotoxicity in cancer cells. These bioactive compounds also regulate cell proliferation, survival, and apoptotic and antiapoptotic signalling pathways. In this review, we discuss (i) how ROS is generated and (ii) regulated and (iii) the cell signalling pathways affected by ROS. We also discuss (iv) the various dietary phytochemicals that have been implicated to have cancer therapeutic effects through their ROS-related functions.
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Cites
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Cited by
The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
Kma, L., & Baruah, T. J. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2104 · Cited by 394
Benameur, T., Porro, C., Twfieg, M.-E., Benameur, N., Panaro, M. A., Filannino, F. M., & Hasan, A. (2023) · Brain Sciences · doi:10.3390/brainsci13081226 · Cited by 60
Metadata
- Authors
- NavaneethaKrishnan, S., Rosales, J. L., & Lee, K.-Y.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2019-05-14
- Volume
- 2019
- Pages
- 1-16
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2945363791
- Cited by
- 217
- References
- 11
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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