Emerging Paradigms in Inflammatory Disease Management: Exploring Bioactive Compounds and the Gut Microbiota
Open accessAbstract
The human gut microbiota is a complex ecosystem of mutualistic microorganisms that play a critical role in maintaining human health through their individual interactions and with the host. The normal gastrointestinal microbiota plays a specific physiological function in host immunomodulation, nutrient metabolism, vitamin synthesis, xenobiotic and drug metabolism, maintenance of structural and functional integrity of the gut mucosal barrier, and protection against various pathogens. Inflammation is the innate immune response of living tissues to injury and damage caused by infections, physical and chemical trauma, immunological factors, and genetic derangements. Most diseases are associated with an underlying inflammatory process, with inflammation mediated through the contribution of active immune cells. Current strategies to control inflammatory pathways include pharmaceutical drugs, lifestyle, and dietary changes. However, this remains insufficient. Bioactive compounds (BCs) are nutritional constituents found in small quantities in food and plant extracts that provide numerous health benefits beyond their nutritional value. BCs are known for their antioxidant, antimicrobial, anticarcinogenic, anti-metabolic syndrome, and anti-inflammatory properties. Bioactive compounds have been shown to reduce the destructive effect of inflammation on tissues by inhibiting or modulating the effects of inflammatory mediators, offering hope for patients suffering from chronic inflammatory disorders like atherosclerosis, arthritis, inflammatory bowel diseases, and neurodegenerative diseases. The aim of the present review is to summarise the role of natural bioactive compounds in modulating inflammation and protecting human health, for their safety to preserve gut microbiota and improve their physiology and behaviour.
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Chlorella vulgaris extracts bolster mucosal immunity by stimulating secretory IgA production and modulating dendritic cell function.
“Extracts from Chlorella vulgaris have been demonstrated to bolster mucosal immunity by stimulating secretory IgA production and modulating dendritic cell function [64].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [64]
Section 5 discusses the intestinal mucosal barrier and identifies dendritic cells as part of the intestinal innate immune system, but does not connect them to Chlorella vulgaris extracts. Searches for “Chlorella,” “secretory IgA,” and “IgA” found no passage reporting the claimed effects; page numbers were not available in our copy. (LLM, conf=0.76)
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Microalgae Bioactives for Functional Food Innovation and Health Promotion
Guil-Guerrero, J. L., & Prates, J. A. M. (2025) · Foods · doi:10.3390/foods14122122 · Cited by 47 · see citing works
- Authors
- Benameur, T., Porro, C., Twfieg, M.-E., Benameur, N., Panaro, M. A., Filannino, F. M., & Hasan, A.
- Affiliations
- Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia
- University of Foggia (IT)
- King Faisal University (SA)
- University of Biskra (DZ)
- University of Bari Aldo Moro (IT)
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2023-08-21
- Volume
- 13
- Issue
- 8
- Pages
- 1226
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC10452544
- OpenAlex
- W4386032700
- Cited by
- 60
- References
- 158
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 15 · 2023: 2 · 2014: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- bioactive compounds, gut microbiota, inflammation, anti-inflammatory activity, dietary phytochemicals, antioxidant activity, immunomodulation, intestinal barrier integrity, chronic inflammatory diseases, atherosclerosis, arthritis, inflammatory bowel disease, neurodegenerative diseases
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