The effect of acute aerobic exercise on redox homeostasis and mitochondrial function of rat white adipose tissue
Open accessAbstract
Physical exercise is characterized by an increase in physical and metabolic demand in face of physical stress. It is reported that a single exercise session induces physiological responses through redox signaling to increase cellular function and energy support in diverse organs. However, little is known about the effect of a single bout of exercise on the redox homeostasis and cytoprotective gene expression of white adipose tissue (WAT). Thus, we aimed at evaluating the effects of acute aerobic exercise on WAT redox homeostasis, mitochondrial metabolism, and cytoprotective genic response. Male Wistar rats were submitted to a single moderate‐high running session (treadmill) and were divided into five groups: control (CTRL, without exercise), and euthanized immediately (0 h), 30 min, 1 hour, or 2 hours after the end of the exercise session. NADPH oxidase activity was higher in 0 h and 30 min groups when compared to CTRL group. Extramitochondrial ROS production was higher in 0 h group in comparison to CTRL and 2 h groups. Mitochondrial respiration in phosphorylative state increased in 0 h group when compared to CTRL, 30 min, 1, and 2 h groups. On the other hand, mitochondrial ATP production was lower in 0 h in comparison to 30 min group, increasing in 1 and 2 h groups when compared to CTRL and 0 h groups. CAT activity was lower in all exercised groups when compared to CTRL. Regarding oxidative stress biomarkers, we observed a decrease in reduced thiol content in 0 h group compared to CTRL and 2 h groups, and higher levels of protein carbonylation in 0 and 30 min groups in comparison to the other groups. The levels returned to basal condition in 2 h group. Furthermore, aerobic exercise increased NRF2, GPX2, HMOX1, SOD1, and CAT mRNA levels. Taken together, our results suggest that one session of aerobic exercise can induce a transient prooxidative state in WAT, followed by an increase in antioxidant and cytoprotective gene expression.
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Similar metabolic pathways are triggered by physical activity and calorie restriction with diet.
“Similar metabolic pathways are also triggered by physical activity and calorie restriction with diet.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [24]
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HEPATIC AND SKELETAL MUSCLE TISSUE IMMUNOMETABOLISM IN TRAINED RATS
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IMUNOMETABOLISMO TECIDUAL HEPÁTICO E MUSCULAR ESQUELÉTICO DE RATOS TREINADOS
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- Authors
- Matta, L., Fonseca, T. S., Faria, C. C., Lima-Junior, N. C., De Oliveira, D. F., Maciel, L., Boa, L. F., Pierucci, A. P. T. R., Ferreira, A. C. F., Nascimento, J. H. M., Carvalho, D. P., & Fortunato, R. S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Fortunato, Rodrigo S.
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 4593496-4593496
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC7868166
- OpenAlex
- W3128375699
- Cited by
- 28
- References
- 67
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 4
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- acute aerobic exercise, white adipose tissue, redox homeostasis, mitochondrial function, reactive oxygen species, NADPH oxidase, oxidative stress, antioxidant gene expression, Nrf2, protein carbonylation, thiol content, mitochondrial respiration, treadmill running, cytoprotective genes
- MeSH terms
- Adenosine Triphosphate, Animals, Antioxidants, Gene Expression Regulation, Homeostasis, Male, Mitochondria, Oxidation-Reduction, Physical Conditioning, Animal, Retroperitoneal Space, RNA, Messenger, Biomarkers, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Cell Respiration, NADPH Oxidases, Lactic Acid, Rats, Adipose Tissue, White
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