Nrf2 mediates redox adaptations to exercise

Free radicals and antioxidants in normal physiological functions and human disease

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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Nrf2:INrf2 (Keap1) signaling in oxidative stress

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Antioxidants prevent health-promoting effects of physical exercise in humans

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Oxidative stress and gene regulation

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Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

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Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training

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Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

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Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

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Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

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The Molecular Bases of Training Adaptation

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The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

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Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle: Molecular responses during mitochondrial biogenesis

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Nrf2: friend or foe for chemoprevention?

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Antioxidants and oxidants regulated signal transduction pathways

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Role of Polyphenols and Other Phytochemicals on Molecular Signaling

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Hormetic Dietary Phytochemicals

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Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system

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Anthocyanins Induce the Activation of Phase II Enzymes through the Antioxidant Response Element Pathway against Oxidative Stress-Induced Apoptosis

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Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

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Effect of Antioxidants Supplementation on Aging and Longevity

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Lifelong physical exercise delays age-associated skeletal muscle decline

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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Nuclear factor erythroid‐derived 2‐like 2 (NFE2L2, Nrf2) mediates exercise‐induced mitochondrial biogenesis and the anti‐oxidant response in mice

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Antioxidant supplements and mortality

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Antioxidant Supplementation Reduces Skeletal Muscle Mitochondrial Biogenesis

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Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy

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Mechanism of Chemical Activation of Nrf2

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The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

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Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Gounder, S. S., Kannan, S., Devadoss, D., Miller, C. J., Whitehead, K. S., Odelberg, S. J., Firpo, M. A., Paine, R., Hoidal, J. R., Abel, E. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045697 · Cited by 171 · see citing works

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

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Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

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Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

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The Predicted Molecular Weight of Nrf2: It Is What It Is Not

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Translational Control of Nrf2 Protein in Activation of Antioxidant Response by Oxidants

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Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane

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You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging

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NRF2, cancer and calorie restriction

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Exercise-induced skeletal muscle signaling pathways and human athletic performance

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Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats

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The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

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Lifelong training preserves some redox-regulated adaptive responses after an acute exercise stimulus in aged human skeletal muscle

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Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats

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Exercise-induced Nrf2-signaling is impaired in aging

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Acute exercise stress promotes Ref1/Nrf2 signalling and increases mitochondrial antioxidant activity in skeletal muscle

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Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

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Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome

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Translational Geroscience: Emphasizing function to achieve optimal longevity

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Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells

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Aging of signal transduction pathways, and pathology

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Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response

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Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

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Single bouts of exercise affect albumin redox state and carbonyl groups on plasma protein of trained men in a workload-dependent manner

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Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators

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Roles of Keap1–Nrf2 System in Upper Aerodigestive Tract Carcinogenesis

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NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction

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Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle

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Ginsenoside Rg3 improves cardiac mitochondrial population quality: Mimetic exercise training

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Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice

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Exercise activates redox-sensitive transcription factors and restores renal D 1 receptor function in old rats

George, L. E., Lokhandwala, M. F., & Asghar, M. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00397.2009 · Cited by 58 · see citing works

Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies

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Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer

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Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube

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Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.

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Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma

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The Impact of Previous Physical Training on Redox Signaling after Traumatic Brain Injury in Rats: A Behavioral and Neurochemical Approach

Fiorin, F. D. S., Ferreira, A. P. D. O., Ribeiro, L. R., Silva, L. F. A., de Castro, M. R. T., da Silva, L. R. H., da Silveira, M. E. P., Zemolin, A. P. P., Dobrachinski, F., Oliveira, S. M., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.4068 · Cited by 44 · see citing works

Exercise-induced oxidative stress and hypoxic exercise recovery

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Identification of age‐specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?

Shenvi, S. V., Smith, E. J. T., & Hagen, T. M. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00788.x · Cited by 43 · see citing works

Comparison of human Nrf2 antibodies: A tale of two proteins

Kemmerer, Z. A., Ader, N. R., Mulroy, S. S., & Eggler, A. L. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.07.004 · Cited by 41 · see citing works

Cordyceps sinensisIncreases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells

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Aerobic interval training protects against myocardial infarction‐induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis

Jiang, H., Miao, Y., Wang, Y., Zhao, M., Feng, Z., Yu, X., Liu, J., & Zang, W. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12211 · Cited by 40 · see citing works

Vitamin E Conditionally Inhibits Atherosclerosis in ApoE Knockout Mice by Anti‐oxidation and Regulation of Vasculature Gene Expressions

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Nitrosative stress in human skeletal muscle attenuated by exercise countermeasure after chronic disuse

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High-protein diet induces oxidative stress in rat brain: protective action of high-intensity exercise against lipid peroxidation.

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Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats

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Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate

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Astrogliopathy as a loss of astroglial protective function against glycoxidative stress under hyperglycemia

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High-intensity Exercise Modifies the Effects of Stanozolol on Brain Oxidative Stress in Rats

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Physical activity and exercise: Strategies to manage frailty

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Cellular and molecular mechanisms of sarcopenia: The S100B perspective

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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

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Antioxidants in Personalized Nutrition and Exercise

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