Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

Newman, D. J., & Cragg, G. M. L. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01285 · Cited by 7,656

Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

Tu, Y. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601967 · Cited by 832

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Sharma, R., Abbasi‐Kangevari, M., Abd-Rabu, R., Abidi, H., Abu-Gharbieh, E., Acuna, J. M., Adhikari, S., Advani, S. M., Afzal, M. S., Meybodi, M. A., et al. (2022) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(22)00044-9 · Cited by 681

Best practice in research - Overcoming common challenges in phytopharmacological research.

Heinrich, M., Appendino, G., Efferth, T., Fürst, R., Izzo, A., Kayser, O., Pezzuto, J., & Viljoen, A. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112230 · Cited by 608

The multifaceted role of reactive oxygen species in tumorigenesis

Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452 · cited 1×

Chemical study and medical application of saponins as anti-cancer agents

Man, S., Gao, W., Zhang, Y., Huang, L., & Liu, C. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.06.004 · Cited by 437

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 321

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280

Fluorescence enhancement and quenching study: Interaction of diosgenin with biologically significant macromolecules

İnci, D., & Erdağı, S. İ. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144413 · Cited by 3

Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway

Gao, W., Wang, D., Shi, Y., Sun, Y. H., Deng, J., Song, X., Zhang, M., & Li, J. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073331615241018081811 · Cited by 3

How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study

Dissemond, J., Havers, T., Held, S., Geisler, S., Kostov, T., Diel, P., Türschmann, S., Parr, M. K., & Isenmann, E. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2540408 · Cited by 2

BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat

Casimiro-Rosas, M., Parra, I., Sandoval-Ramı́rez, J., Herrera, M. A. F., Tizabi, Y., Martínez-García, I., & Mendieta, L. (2025) · Steroids · doi:10.1016/j.steroids.2025.109602 · Cited by 2

Tupistra Nutans:A comprehensive review of morphology, phytochemical profile, and Pharmacological activity”

Acharjya, R., Bhattacharjee, A., Chakraborty, M., Ali, M. H. J., Sharma, C., Bhattarai, A., Rai, A., Rai, Y., Bhuyan, N. R., & Ghosh, S. (2025) · Clinical Phytoscience · doi:10.1186/s40816-025-00394-1 · Cited by 2

Role of diosgenin in gastrointestinal cancers: recent trends and future perspectives

Kumar, A., Amita, Singh, B., Sharma, P., Raina, R., Sharma, B., Haque, S., & Tuli, H. S. (2025) · Medical Oncology · doi:10.1007/s12032-025-02947-3 · Cited by 2

Diosgenin ameliorates CLP-induced sepsis in mice via suppressing inflammatory responses and preserving intestinal mucosal barrier integrity

Li, Y., Zeng, J., Zhong, X., Huang, Q., Wang, X., Sun, S., Wang, H., Huang, X., Ling, J., & Lin, R.-F. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.10.005 · Cited by 2

Geographical Variation Shapes Nutritional Metabolite Profile and Food Functionality of Houttuynia cordata

Zhang, Y.-Y., Fu, X., Zhu, J., Gui, Y., Huang, H., Liao, Y., Mao, Y., Tian, H., & Liu, L. (2025) · Metabolites · doi:10.3390/metabo15110701 · Cited by 2

The Combination of Diosgenin, Vitamin D, and α-Lactalbumin Normalizes the Menstrual Cycle in Women with PCOS of Phenotype D: A Pilot Clinical Study

Russo, M., Porcaro, G., Aragona, C., Bilotta, G., Liberto, M. D., & Unfer, V. (2025) · Nutrients · doi:10.3390/nu17233695 · Cited by 2

Risks, Benefits, and Molecular Targets of Fenugreek Administration in the Treatment of Hepatocellular Carcinoma

Vittal, M., Menegassi, B., & Vinciguerra, M. (2026) · Cancers · doi:10.3390/cancers18030458 · Cited by 2

Herbal intervention targeting NLRP3 inflammasome in the treatment of liver diseases

Mendon, A., Mishra, N., Jain, S., & Bhatt, L. K. (2026) · Next research. · doi:10.1016/j.nexres.2026.101457 · Cited by 2

Diosgenin alleviates hepatic fibrosis via PI3K/Akt/mTOR mediated fatty acid metabolic reprogramming and NF-κB activation

Shi, Y., Zhang, Y., Liu, D., Xiang, S., Liang, S., 林玩福, Li, S., Zhai, X., & Cheng, B. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121747 · Cited by 2

A highly-sensitive and selective LC–MS/MS platform for quantitative determination of diosgenin in mice plasma with comprehensive bioanalytical validation and pharmacokinetic study

Khude, H., Pai, R. V., & Shende, P. K. (2026) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2026.07.008 · Cited by 2

Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury

Ghosian-Moghaddam, M.-H., Moghaddam, P. M., & Roghani, M. (2024) · Drug Research · doi:10.1055/a-2263-1329 · Cited by 2

Proximate, Selected Elements and Bioactive Compounds in Jatropha tanjorensis and Bryophyllum pinnatum Leaves

Bennett, V., Amos-Tautua, B., & Ebong, C. U. (2024) · International Research Journal of Pure and Applied Chemistry · doi:10.9734/irjpac/2024/v25i4866 · Cited by 2

Diosgenin production from Dioscorea zingiberensis tubers by novel pressurized hydrolysis in acidic ionic liquids

Xia, G., Dai, Y., Zhou, J., Zhang, M., Wang, M., Yang, H., Shen, Y., & Yang, P. (2024) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2024.100596 · Cited by 2

Production of encapsulated (25R)-Spirost-5-en-3β-ol powder with composite coating material and its characterization

Arya, P., & Kumar, P. (2023) · Steroids · doi:10.1016/j.steroids.2023.109218 · Cited by 2

Epoxide of diosgenin acetate synthesis: DoE for diastereoselective yield optimization, antimicroibial, antioxidant and antiproliferative effects

Hernández-Rivera, J. A., Herrera-García, M., López-Castillo, G. N., Sandoval-Ramı́rez, J., & Carrasco‐Carballo, A. (2023) · Steroids · doi:10.1016/j.steroids.2023.109256 · Cited by 2

Telomerase Inhibition Potential of Natural Compounds in Leukemia TreatmentPreprint

Bartoszewska, E., Molik, K., Choromańska, A., & Woźniak, M. (2024) · Preprints.org · doi:10.20944/preprints202401.0362.v1 · Cited by 2

Exploring the therapeutic potential of Cynanchum tunicatum (Retz.) Alston- assessment of phytochemicals and biological activities

Krishnamoorthy, D., Swaminathan, A., AlGarawi, A. M., Nallasamy, L., Murugavelu, G. S., & Selvaraj, S. L. (2024) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2024.103238 · Cited by 1

Identification of potential therapeutic phytocompounds targeting the G-glycoprotein of Nipah Virus: an in-silico study

Islam, M. T., Ulla, S. N., Islam, S., & Ashraf, A. (2025) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2025.2458334 · Cited by 1

Establishment of in vitro root cultures and hairy roots of Dioscorea composita for diosgenin production

Sánchez-López, G. C., Carranza-Ojeda, D., Pérez‐Picaso, L., Martínez-Pascual, R., Viñas‐Bravo, O., López-Torres, A., Molphe-Bach, E. P., García-Ríos, E., Morales‐Serna, J. A., & Villalobos-Amador, E. (2025) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-025-03022-5 · Cited by 1

Diosgenin producing Bacillus sp. strain IRMC27M2 as a genome-mined weapon against multidrug-resistant Candidozyma (Candida) auris

Alquwaie, R., Almandil, N. B., AlJindan, R. Y., Mahmoud, N., Almofty, S. A., Almohazey, D., Alqudihi, H. H., Hunachagi, S., Dhas, T. S., Sowmiya, P., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.07.048 · Cited by 2

Potential of Fenfuro ® , a novel, standardized Trigonella foenum-graecum (Fenugreek) seed extract, in ameliorating glycation-mediated amyloidogenesis

Saha, S., Kumar, P., Bagchi, M., Bhattacharya, D., Chakraborty, S., Chakraborty, S., Banik, S. P., & Bagchi, D. (2025) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2567419 · Cited by 1

Diosgenin-functionalized zinc oxide nanoparticles produced using Hibiscus tiliaceus leaf extract: evaluation of anticancer and antibacterial activities

Putri, O. K., Wulansari, D., Fadlan, A., Santoso, M., Wiraswati, H. L., & Kusumawati, Y. (2025) · OpenNano · doi:10.1016/j.onano.2025.100274 · Cited by 1

The gasotransmitters hydrogen sulfide and nitric oxide independently regulate growth, physiology, and secondary metabolism in fenugreek (Trigonella foenum-graecum L.)

Sana, Gill, S. S., & Naeem, M. (2026) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2026.111227 · Cited by 1

Scale-Up Isolation of High-Purity Shatavarins from Asparagus racemosus via Flash Chromatography with Bioavailability and Pharmacological Insights

C, D. D., Girme, A., Salvankar, K., Chinchansure, A. A., Ranjan, R., L, Y. K. N., Richard, E. J., & Mundkinajeddu, D. (2026) · ACS Omega · doi:10.1021/acsomega.6c00145 · Cited by 1

Immunomodulatory and locomotor regulations via Diosgenin treatment in lipopolysaccharide-induced chronic fatigue syndrome (CFS)/ depressive despair symptom: an in vivo assessment

Shirole, R. L., Khalane, M. R., Nage, V. P., Shirole, N. L., Chawre, S. V., Alsayari, A., Wahab, S., Bhunia, A., & Patil, D. K. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05263-3 · Cited by 1

Diosgenin-loaded niosomes ameliorate cadmium-induced neurotoxicity and endocrine disruption in female rats through modulation of oxidative stress, apoptosis, and inflammatory markers

Hashmi, K., Saleem, A., Sabir, S., Ehsan, S., Mobashar, A., Khan, M. I., Shahnaz, Ahmad, Z., Akhtar, M. F., Dauelbait, M., et al. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05239-3 · Cited by 1

Nanotechnology-enabled targeted delivery of incretin therapies for the treatment of obesity and metabolic disorders

Uti, D. E., Egbung, J. E., Alum, E. U., Bawa, I., Agada, S. A., Ogbu, C. O., & Ugwu, O. P.-C. (2026) · Obesity Medicine · doi:10.1016/j.obmed.2026.100712 · Cited by 1

Diosgenin enhances transplanted human oligodendrocyte precursor cell-mediated myelination in preterm white matter injury by inhibiting matrix metalloproteinase-9–driven TGF-β/Smad2/3 signaling

Lai, Q., Yao, X., Bai, L., Cao, X., Zhao, Y., Wang, C., Luan, Z., Feng, Z., & Yao, R. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e01046 · Cited by 1

Identification of selective bioactive compounds from Fenugreek seed extracts by GC-MS analysis and their anti-tumoral potential via modulation of Parkin in oral cancer

Kumari, R., Rani, M., Reddy, M., Ram, S., Khan, I., & Rizvi, M. M. A. (2026) · In Silico Pharmacology · doi:10.1007/s40203-026-00711-7 · Cited by 1

CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance

Asha, A., & Sunita, J. V. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-30037-0_57-1 · Cited by 1

Preparation Of Diosgenin-Encapsulated Microspheres By Spray Drying Technique

Tiwari, R. H., Mangla, M., Sanduja, M., & Nayak, A. K. (2023) · International Journal of Membrane Science and Technology · doi:10.15379/ijmst.v10i4.3634 · Cited by 1

Review of Saponins in Treating Heart Failure

Zeng, Q., Shi, M., Wei, J., Li, Y., & Guo, Z. (2024) · SciBase epidemiology and public health. · doi:10.52768/epidemiology/1022 · Cited by 1

Development and Validation of an HPLC Method for Diosgenin, A Bioactive Compound in the Rhizomes of Chamaecostus cuspidatus

Saliya, H., Madam, J., Patel, H. D., Lakhani, M., Patel, V., Shah, L., Vyas, V., & Shah, M. B. (2025) · Pharmacognosy Research · doi:10.5530/pres.20252199 · Cited by 1

Phytocompositions of ayurvedic medicine in the restoration of menstrual health in women of early reproductive age who have survived moderate and severe form of COVID-19

Носенко, О. М., Moskalenko, T. Y., Chaykivska, E. F., & Ni, D. T. S. (2023) · Reproductive Endocrinology · doi:10.18370/2309-4117.2023.69.104-112 · Cited by 1

Diosgenin Attenuates Nonalcoholic Fatty Liver Disease Through the Hepatic Nlrp3 Inflammasome-Dependent Signaling PathwayPreprint

Yu, W., Yin, G., Chen, S., Zhang, X., Meng, D., Wang, L., Liu, H., Jiang, W., Sun, Y., & Zhang, F. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4812410 · Cited by 1

Especial diseño 2007: 5 claves para el diseño español

Faerna, J. M., & Astigarraga, M. P. (2007) · Diseño interior

Phytotherapeutika zur Behandlung von vasomotorischen Symptomen im Klimakterium

Zeun, S. (2022) · Zeitschrift für Phytotherapie · doi:10.1055/a-1874-9617

Library-based UHPLC-Q-Exactive-Orbitrap-MS Putative Identification of Isomeric and Non-isomeric Compounds from Shenling Baizhu Granule and its Pharmacopoeia Quality-marker ChemistryPreprint

Li, X., Zeng, J., Cai, R., Chen, B., Li, C., Hu, Q., & Sun, Y. (2023) · doi:10.22541/au.168478029.91639355/v1

Soybean Protein Based Diosgenin Nanoemulsions: Fabrication, Stability and in Vitro Study Using Caco-2 CellsPreprint

Li, G., Liu, Q., Gao, A., Ren, L., Zhang, Y., guo, W., He, S., Gao, F., & Peng, X. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4481485

Bioactive Compounds and Biological Activities of Nepal Yam (Dioscorea deltoidea wall. Ex Griseb.)

Sati, P., Trivedi, V. L., Semwal, P., & Nautiyal, M. C. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-29006-0_38-1

Formulation And Evaluation Of Diosgenin Gel For Its In Vivo Anti-Skin Cancer Activity

Tiwari, R. H., & Sanduja, M. (2023) · Journal for ReAttach Therapy and Developmental Diversities · doi:10.53555/jrtdd.v6i1.2573

Bioactive Compounds and Biological Activities of Nepal Yam (Dioscorea deltoidea wall. Ex Griseb.)

Sati, P., Trivedi, V. L., Semwal, P., & Nautiyal, M. C. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-44746-4_38

Diosgenin Mediated JAK/STAT Signal Channel Improving SD Rat Renal Ischemia-Reperfusion

Yang, J., Li, X., Long, C., Zhang, Y., Yang, H., Chen, T., Wang, X., & Huang, X. (2024) · Transplantation Proceedings · doi:10.1016/j.transproceed.2024.11.007

Botanical Bounty: Exploring Aphrodisiac Drug Discovery and Development from Nature's Pharmacy

Bilal, M., Jain, D., Chaitanya, M., Khurana, N., Singh, S., Mazumder, A., & Singh, K. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072334775241209052941

Exploration of Potential Therapeutic Targets of Diosgenin in Pulmonary Fibrosis through Network Pharmacology and Mendelian RandomizationPreprint

徐, 文., 黄, 文., Xin, G., & 潘, 文. (2024) · Research Square · doi:10.21203/rs.3.rs-5661693/v1

Exploring the Mechanism of Sishen Decoction in Intervening Diarrhea-Predominant Irritable Bowel Syndrome with Depression Based on Network Pharmacology

谢, 小. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.151085

Comparative estimation of ROS levels in zebrafish larvae on the treatment of diosgenin and doxorubicin under stress conditions for antioxidant property

Maria, S., & Kumar, I. P. (2025) · AIP conference proceedings · doi:10.1063/5.0258681

Exploring the Mechanism of Yougui Pill against Aging Based on Network Pharmacology and Molecular Docking Study

Yang, H., Shi, Q., & Ji, C.-Y. (2025) · Chinese medicine and natural products · doi:10.1055/s-0045-1807269

CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance

Asha, A., & Sunita, J. V. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-51158-5_57

Antioxidant Activity Test and Antibacterial Gel Formulation of Ethanol Extract of Black Ginger (Curcuma aeruginosa Roxb.) Rhizome

Fahdi, F., Sari, R. P., Harahap, N. I., & Harnis, Z. E. (2025) · International Journal of Advancement in Life Sciences Research · doi:10.31632/ijalsr.2025.v08i02.013

Tuber diversity of Dioscorea hispida from Muna Island, Indonesia, for potential microencapsulated bioherbicide agents

PUTRI, W. E., Johannes, E., & Sjafaraenan, S. (2025) · Asian Journal of Agriculture · doi:10.13057/asianjagric/g090118

Novel Granular Formulation of Solanum nigrum and Cichorium intybus Leaf Juice Hepatoprotective Effects Against Paracetamol-induced Toxicity in Rats

Khatoon, S., Rahman, K., Sultana, A., & Fakeha-firdous, K. (2025) · Current Drug Therapy · doi:10.2174/0115748855399874250726091823

Formulation of a novel Diosgenin-loaded nanoemulsion and its evaluation for improved brain bioavailability in the management of cerebral ischemia

Ahmad, N., Ansari, K., Alyami, H. M., Alqahtani, A. J., Merghani, A., & Ahmad, S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107468 · Cited by 1

Evaluation of molecular interaction studies of khellin on bovine serum albumin through various biophysical approaches

Manoharan, S. P., Gnanaselvan, S., Ramakrishnan, S. P., Yadav, S. A., Priya, L. S., Manikandan, A., Gnanasekaran, L., Santhamoorthy, M., & Santhoshkumar, S. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.11.008

Molecular insights into diosgenin's role in preventing protein aggregation in neurodegenerative diseases

Parveen, N., Qais, F. A., & Faheem, M. (2025) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2025.141116

Targeted Ultra‐High Performance Liquid Chromatography–Electrospray Ionization Triple Quadrupole Mass Spectrometry‐Based Quantification of Diosgenin in Hellenia speciosa for Its Wild Populations Screening: A Quality Control Assessment

Singh, P., Samanthula, G., Chandana, J. M., Ramchandran, R. K., Kodam, C., Suraj, Neelu, S., & Bhаdoriyа, K. (2025) · Separation Science Plus · doi:10.1002/sscp.70167

Diosgenin targets ITGA11-driven angiogenesis in hepatocellular carcinoma: Prognostic and mechanistic insights

Zheng, H., Tang, S., Yu, Z., Shi, R., Zhang, R., Qu, X., Wan, H., Fang, C., Wang, X., Zhu, Y., et al. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108822

Evaluation of Diosgenin-Enhanced Gelatin/Hydroxyapatite Biomaterial for Bone Regeneration Using in Silico, in Vitro, and Zebrafish Models

Maragathavalli, J. B., Srinivasan, S., Vijayalekha, A., Udaiappan, J., Kaliaraj, G. S., Anandasadagopan, S. K., & Pandurangan, A. K. (2025) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00531-9

Additional file 2 of Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

Shi, S. U. N., Li, Y., Jia, L., Ye, S., & Luan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26733543

Additional file 1 of Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer

Bahadar, N., Bahadar, S., Sajid, A., Wahid, M., Ali, G., Alghamdi, A., Zada, H., Khan, T., Ullah, S., & Sun, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26746118

Additional file 1 of Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

Shi, S. U. N., Li, Y., Jia, L., Ye, S., & Luan, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26733540

Efficient saponin glycosidases of Aspergillus tubingensis HG57 enable green diosgenin production using Dioscorea zingiberensis tubers

Chen, Y., Chen, Z., Shu, T., Wang, Z., Fu, C., & Longjiang, Y. (2025) · Bioresource Technology · doi:10.1016/j.biortech.2025.133877

Structural basis for diosgenin as an inverse agonist of retinoic acid receptor-related orphan receptor γ

Chen, S., Tian, S., Liang, J., Wang, R., & Li, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-35006-6

Paris polyphylla Sm. A threatened herb of the Himalayas: traditional knowledge, therapeutic significance and conservation urgency

Barman, T., Lata, S., Das, T., Sharma, S., Paul, S., Kumari, P., & Rana, D. (2026) · Genetic Resources and Crop Evolution · doi:10.1007/s10722-025-02631-5

Mechanism of Babao Dan on fluorouracil-induced bone marrow suppression and T cell immune disorder through MAPK pathway

Yan, S., Sun, R., Yuan, J., Jia, P., Yang, R., He, J., Guo, J., Liu, Y., Liu, J., Chen, X., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-35751-8

Therapeutic potential of gallic acid and diosgenin in metabolic dysfunction-associated steatotic liver disease (MASLD) and non-alcoholic fatty liver disease (NAFLD): A comprehensive review

Satapathy, T., Verma, M., Sahu, P., & Minj, A. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100525

In-silico identification of anti-cholera phytochemicals from Indian medicinal plants

Rahman, K., Akter, Y., Reza, M. S., Pappu, M. A. A., Karim, M. R., Sultana, M., Islam, M. T., Alam, M., Mollah, M. N. H., & Monir, M. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0342058

Fenugreek as a Versatile Cosmetic Ingredient: Phytochemical Profile, Skin–Hair Benefits and Formulation Opportunities

Rebey, I. B., Abdennebi, A. B., Chaabani, E., Yeddes, W., Hammami, M., Tounsi, M. S., & Merah, O. (2026) · Cosmetics · doi:10.3390/cosmetics13010044

Protective effects of diosgenin against non-alcoholic fatty liver disease through inhibiting the STING-dependent inflammatory pathway

Song, C., Yin, G., Meng, Y., Wang, L., & Zhang, F. (2026) · European journal of medical research · doi:10.1186/s40001-026-04168-4

Systematic Optimization of Acid Hydrolysis Parameters for Diosgenin Extraction Coupled with UHPLC-DAD Analysis

Ahmad, R., Amir, M., Aldholmi, M., Alqathama, A. A., Riaz, M., Al-Kawi, M., & Al-Naeem, F. (2026) · Food Analytical Methods · doi:10.1007/s12161-026-03091-y

Dioscin-rich extract of Dioscorea floribunda ameliorates metabolic syndrome by improving inflammation-mediated gut, adipose and hepatic dysfunctions: a pre-clinical study

Sen, S., Mishra, A. U., Sahu, M., Singh, M., Pathak, N., Gupta, A. K., Shanker, K., Negi, A. S., Mani, D. N., & Bawankule, D. U. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02143-3

The role and mechanism of diosgenin glucoside in modulating megakaryopoiesis through promotion of autophagy via the AMPK/mTOR/ULK1 signaling pathway

Kong, W., Li, Z., liu, Z., Wang, L., & Luo, J. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117337

Synergistic Enhancement of Diosgenin Dissolution and Bioavailability via Ternary Solid Dispersions and Self-Assembled Polymeric Micelles

Li, J.-Y., Zhao, M., Zhang, Y. K., Chen-ye, L., Jin-hua, C., Wang, R., Liu, P., & Zhou, J.-Y. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s577261

Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers

Zhou, X., Wang, Z., & Zheng, S. (2026) · World Allergy Organization Journal · doi:10.1016/j.waojou.2026.101412

Assessment of the diosgenin content of various accessions and the epicarp, pulp, and seed kernels of Balanites roxhburghii Planch

Murthy, H. N., Yadav, G. G., Manasa, V., Tumaney, A. W., & Park, S. M. (2026) · Natural Product Research · doi:10.1080/14786419.2026.2683704

Diosgenin Attenuates Photoreceptor Degeneration in an N-Methyl-N-Nitrosourea–Induced Mouse Model of Retinal Degeneration

Tong, W., Cao, J., Zhou, X., Jia, B., Li, D., & Fu, J. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.6.10

Biocatalytic strategies for steroid synthesis: from side-chain remodeling to precision scaffold functionalization

Zheng, M., & Qu, X. (2026) · Chemical Communications · doi:10.1039/d6cc02702d

Clinical Evidence and Significance of Plant Secondary Metabolites in Anti-aging Therapies

Sytar, O. (2026) · Springer eBooks · doi:10.1007/978-981-95-8064-4_2

Extraction techniques, mechanistic insights for gut health, microbiota modulation, and industrial applications of diosgenin

Rao, T., Abbas, A., Bilal, M., Shabbir, H., Zubairi, M. N., Hussain, A., & Elkhedir, A. E. E. (2026) · Discover Chemistry. · doi:10.1007/s44371-026-00842-y

Research progresses on natural product monomers in the treatment of rheumatoid arthritis

Gao, Z.-C., He, C., Zhang, N., Zhou, X., Zhang, Y. P., 伏佳, Li, P.-Q., Chu, H., Zhao, D., Li, P., et al. (2026) · Current Pharmaceutical Analysis · doi:10.1016/j.cpan.2026.07.001

Acute and Chronic Toxicity Assessment of Diosgenin Polyethylene Glycol Succinate in Wistar Rats: Safety Evaluation of a Novel Universal Solubilizer

Velmurugan, V., Shanmugham, V., & Arumugam, T. (2026) · International Journal of Toxicology · doi:10.1177/10915818261469132

Effects of oral fenugreek-derived preparations on testosterone-related outcomes in adult men: a systematic review and meta-analysis of randomized placebo-controlled trials

Yang, P., Niu, Z., Guo, J., Huang, T., Chang, D., & 黄晓朋 (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1903508

Nature’s estrogen: Dioscorea and the emerging potential of β-selective estrogen receptor modulation in menopause

Halder, S., Pal, D., Biswas, A. S., Goswami, S., Hazra, S., Barık, V., Banerjee, S., Mandal, A., Sharma, S., & Naskar, S. (2026) · Food and Humanity · doi:10.1016/j.foohum.2026.101449

Comparative Transcriptomic Analysis Provides Insights into PSK-α-Mediated Regulation of Diosgenin Biosynthesis in Trigonella foenum-graecum

Xu, C.-J., Zhan, H., Mehraliyeva, M., Liu, H., Zheng, M., Li, C., & Zhang, Y. (2026) · Molecules · doi:10.3390/molecules31173046

Agro-Industrial Potential of Yam (Dioscorea spp.): From Biological and Chemical Characterization to Industrial Applications and Valorization

Paternina-Sierra, K., Alfieri, F., Julio-González, L. C., López‐Padilla, A., Montero, P. M., Moreno, F. J., & Hernández‐Hernández, O. (2026) · Foods · doi:10.3390/foods15183178

Harnessing Nature's Arsenal: The multitarget anticancer and antidiabetic networks of saponins

Xu, M., Liang, Z., Zhang, Y., & Xia, P. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101514

Trillin alleviates rheumatoid arthritis by inhibiting TXNIP-mediated mitochondrial damage and NLRP3-dependent pyroptosis

He, J., Wang, X., Lian, X., She, Y., Xu, W., Sun, X., Li, Y., Cao, P., & Zhao, C. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118489

Preclinical advances on diosgenin-loaded nanomedicines

Matias, M., Martins, A. S., & Silvestre, S. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2734068

Diosgenin suppresses ALOX5 expression through Histone acetyltransferase KAT2A-mediated H3K27ac modification to attenuate macrophage ferroptosis and foam cell formation in atherosclerosis

Huang, Q., Ou, H., Li, Y., Li, L., Zhuo, W., & Lin, H. (2026) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2026.107031

Diosgenin Alleviates Neuropathic Pain Associated with Alterations in Spinal Mitochondrial and ER Stress-Related Factors in CCI Mice

Rahman, M. M., 윤태수, Yum, S. H., Shim, Y. W., Jo, Y. Y., & Park, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198624

Plant-derived phytochemicals as immune checkpoint modulators: a systematic review of natural compounds targeting pd-1, pd-l1, ctla-4 and related mechanisms in cancer immunotherapy

Jayathilaka, N. S., Weththasinghe, A. V., Lewis, A. N. S., Athapaththu, A. M. A. S., Wijekoon, K. J., Ganamurali, N., & Sabarathinam, S. (2026) · Phytochemistry Reviews · doi:10.1007/s11101-026-10322-x

Hydroxypheophytin a Stereoisomers as Principal Bioactive Compounds from Spirulina for the Reduction of Lipids and Appetite.

Henriques, C., Fonseca, A. C., Ribeiro, T., Ferreira-Martins, D., Reis, M., & Urbatzka, R. (2026) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6c00721

Integrated Computational Drug Discovery of Diosgenin‐Based Analogues as PI3K‐Targeted Breast Cancer Inhibitors: QSAR, Molecular Docking, and Molecular Dynamics Insights

Dhiman, S., Chagaleti, B. K., Kathiravan, M. K., Kandasamy, R., & Pallaprolu, N. (2026) · ChemistrySelect · doi:10.1002/slct.74768

Metabolic conversion of dioscin-diosgenin and their interactions with gut microbiota: recent advances

Cui, Y., Chen, J., Huang, L., Yao, J., Zhang, Y., Wang, Y., Yang, J., & Tian, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158873

A review on pharmacological and analytical aspects of diosgenin: a concise report

Patel, K., Gadewar, M. M., Tahilyani, V., & Patel, D. K. (2012) · Natural Products and Bioprospecting · doi:10.1007/s13659-012-0014-3 · Cited by 144

Recent advances of diosgenin in its pharmacologic activities and mechanism

Bo-yang, Y. (2010) · Zhongguo linchuang yaolixue yu zhiliaoxue · Cited by 5

Review Nat. Prod. Bioprospect. 2012, 2, 46–52 DOI 10.1007/s13659-012-0014-3

(2016)

Pharmacological and Therapeutic Aspects of Diosgenin: A Prospects for Its Pharmaceutical Development

Vengaimaran, M., Dhamodharan, K., & Mirunalini, S. (2022) · Book Publisher International (a part of SCIENCEDOMAIN International) · doi:10.9734/bpi/nvbs/v9/1734b

Diosgenin: Therapeutic Action, Pharmacology and Applications

Sanjeev, S., Devi, M. S., Khushboo, M., Roy, V. K., & Gurusubramanian, G. (2017) · Science & Technology Journal · doi:10.22232/stj.2017.05.01.01