Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

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Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

Tu, Y. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601967 · Cited by 832

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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Best practice in research - Overcoming common challenges in phytopharmacological research.

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The multifaceted role of reactive oxygen species in tumorigenesis

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Chemical study and medical application of saponins as anti-cancer agents

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Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 321

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus, M., Martins, A. P. J., Gallardo, E., & Silvestre, S. (2016) · Journal of Analytical Methods in Chemistry · doi:10.1155/2016/4156293 · Cited by 273

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Chen, P.-S., Shih, Y., Huang, H.-C., & Cheng, H.-W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020164 · Cited by 225

Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin

Raju, J., & Mehta, R. (2009) · Nutrition and Cancer · doi:10.1080/01635580802357352 · Cited by 210

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression

Puar, Y., Shanmugam, M. K., Fan, L., Arfuso, F., Sethi, G., & Tergaonkar, V. (2018) · Biomedicines · doi:10.3390/biomedicines6030082 · Cited by 200

Advances in the pharmacological activities and mechanisms of diosgenin

Chen, Y., Tang, Y., Yu, S., Han, Y., Kou, J., Liu, B., & Yu, B. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30053-4 · Cited by 192

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Kamal, F. Z., Lefter, R. M., Ali, A., Ech‐Chahad, A., Truş, C., Ciobica, A. S., & Timofte, D. V. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9965916 · Cited by 181

Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women

Komesaroff, P. A., Black, C. V. S., Cable, V., & Sudhir, K. (2001) · Climacteric · doi:10.1080/cmt.4.2.144.150 · Cited by 172

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Tohda, C., Urano, T., Umezaki, M., Nemere, I., & Kuboyama, T. (2012) · Scientific Reports · doi:10.1038/srep00535 · Cited by 170

Diosgenin targets Akt‐mediated prosurvival signaling in human breast cancer cells

Srinivasan, S., Koduru, S. V., Kumar, R., Venguswamy, G., Kyprianou, N., & Damodaran, C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24419 · Cited by 159

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155

Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

Ghosh, S., More, P. A., Derle, A., Patil, A. B., Markad, P. R., Asok, A., Kumbhar, N., Shaikh, M. L., Boppana, R., Shinde, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106039 · Cited by 151

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei, F., Mirzababaei, M., & Nassiri‐Asl, M. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14317 · Cited by 137

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri, Y., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Ezzat, S. M., Merghany, R. M., Shaheen, S., Azmi, L., Mishra, A. P., Şener, B., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4024331 · Cited by 133

Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective

Salehi, B., Mishra, A. P., Nigam, M., Karazhan, N., Shukla, I., Kiełtyka‐Dadasiewicz, A., SAWICKA, B. H., Głowacka, A., Abu-Darwish, M. S., Tarawneh, A. H., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6884 · Cited by 131

Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances

Cai, B., Zhang, Y., Wang, Z., Xu, D., Jia, Y., Guan, Y., Liao, A., Liu, G., Chun, C., & Li, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3153082 · Cited by 124

Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway

Liu, M., Xu, Y., Han, X., Yin, L., Xu, L., Qi, Y., Zhao, Y., Liu, K., & Peng, J. (2015) · Scientific Reports · doi:10.1038/srep18038 · Cited by 120

Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme

Lv, L., Zheng, L., Dong, D., Xu, L., Yin, L., Xu, Y., Qi, Y., Han, X., & Peng, J. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.012 · Cited by 119

The role of diosgenin in diabetes and diabetic complications

Gan, Q., Wang, J., Hu, J., Lou, G., Xiong, H., Peng, C., Zheng, S., & Huang, Q. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105575 · Cited by 119

Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents

Yuan, Q., Wu, X., Huang, W. Q., Gong, G., Li, D., He, Y., & Zhao, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.047 · Cited by 118

A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance

Souza, C. M., Schwabe, T. M. E., Pichler, H., Ploier, B., Leitner, E., Guan, X. L., Wenk, M. R., Riezman, I., & Riezman, H. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.06.006 · Cited by 117

Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation

Khosravi, Z., Sedaghat, R., Baluchnejadmojarad, T., & Roghani, M. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.047 · Cited by 117

Cucurbita Plants: From Farm to Industry

Salehi, B., Sharifi‐Rad, J., Çapanoğlu, E., Adrar, N., Çatalkaya, G., Shaheen, S., Jaffer, M., Giri, L., Suyal, R., Jugran, A. K., et al. (2019) · Applied Sciences · doi:10.3390/app9163387 · Cited by 117

Apoptosis Induced by Dioscin in Hela Cells.

Cai, J., Liu, M., Wang, Z., & Ju, Y. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.193 · Cited by 114

Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats

Kalailingam, P., Kannaian, B., Eevera, T., & Kaliaperumal, R. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.04.005 · Cited by 112

Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity

He, Z., Chen, H., Li, G., Zhu, H., Gao, Y., Zhang, L., & Sun, J. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.02.002 · Cited by 106

Effects of processing adjuvants on traditional Chinese herbs

Chen, L., Verpoorte, R., Yen, H., Peng, W., Cheng, Y., Chao, J., & Pao, L. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.02.004 · Cited by 105

Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells

Jiang, S., Fan, J., Wang, Q., Ju, D., Feng, M., Li, J., Guan, Z.-B., An, D., Wang, X., & Li, Y. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.010 · Cited by 101

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Jain, D., Chaudhary, P., Varshney, N., Razzak, K. S. B., Verma, D., Zahra, T. R. K., Janmeda, P., Sharifi‐Rad, J., Daştan, S. D., Mahmud, S., et al. (2021) · Journal of Oncology · doi:10.1155/2021/5905357 · Cited by 100

Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases

Tsoukalas, D., Fragoulakis, V., Sarandi, E., Docea, A. O., Papakonstaninou, E., Τσιλιμιδός, Γ., Anamaterou, C., Fragkiadaki, P., Aschner, M., Tsatsakis, A. M., et al. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00120 · Cited by 98

Epibatidine: A Promising Natural Alkaloid in Health

Salehi, B., Sestito, S., Rapposelli, S., Peron, G., Calina, D., Sharifi-Rad, M., Sharopov, F., Martins, N., & Sharifi-Rad, J. (2018) · Biomolecules · doi:10.3390/biom9010006 · Cited by 91

The origin and evolution of the diosgenin biosynthetic pathway in yam

Cheng, J. G., Chen, J., Liu, X., Li, X., Zhang, W., Dai, Z., Lu, L., Zhou, X., Cai, J., Zhang, X., et al. (2020) · Plant Communications · doi:10.1016/j.xplc.2020.100079 · Cited by 89

Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway

Kim, D. S., Jeon, B. K., Lee, Y. E., Woo, W.-H., & Mun, Y. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/981675 · Cited by 88

Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction

Ma, Y., Zhang, Y.-S., Zhang, F., Zhang, Y., Thakur, K., Zhang, J., & Wei, Z. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110655 · Cited by 87

A Review of Recent Studies on the Antioxidant and Anti‐Infectious Properties of Senna Plants

Alshehri, M. M., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Tütüncü, S., Aydar, E. F., Topkaya, C., Mertdinç, Z., Özçelik, B., Aital, M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6025900 · Cited by 86

Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1

Lv, Y.-C., Yang, J., Yao, F., Xie, W., Tang, Y., Ouyang, X.-P., He, P., Tan, Y.-L., Li, L., Zhang, M., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.02.044 · Cited by 85

Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling

Song, X., Wang, Z., Liang, H., Zhang, W., Ye, Y., Li, H., Hu, Y., Zhang, Y., Weng, H., Lu, J., et al. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.18732 · Cited by 84

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Painuli, S., Quispe, C., Herrera‐Bravo, J., Semwal, P., Martorell, M., Almarhoon, Z. M., Seilkhan, A., Ydyrys, A., Sharifi‐Rad, J., Alshehri, M. M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2910411 · Cited by 84

Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation

Kiasalari, Z., Rahmani, T., Mahmoudi, N., Baluchnejadmojarad, T., & Roghani, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.068 · Cited by 83

Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults

Tohda, C., Yang, X., Matsui, M., Inada, Y., Kadomoto, E., Nakada, S., Watari, H., & Shibahara, N. (2017) · Nutrients · doi:10.3390/nu9101160 · Cited by 83

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Wang, G., Chen, H., Huang, M., Wang, N., Zhang, J., Zhang, Y., Bai, G., Fong, W. F., Yang, M., & Yao, X. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.10.050 · Cited by 82

Sterols. CLVII. Sapogenins. LXIX.1 Isolation and Structures of Thirteen New Steroidal Sapogenins. New Sources for Known Sapogenins

Marker, R. E., Wagner, R. B., Ulshafer, P. R., Wittbecker, E. L., Goldsmith, D. P. J., & Ruof, C. H. (1943) · Journal of the American Chemical Society · doi:10.1021/ja01246a051 · Cited by 82

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl

Turchan-Cholewo, J. T., Liu, Y., Gartner, S., Reid, R., Jie, C., Peng, X., Chen, K. C., Chauhan, A., Haughey, N. J., Cutler, R. G., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.005 · Cited by 81

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity

Chen, C.-T., Wang, Z.-H., Hsu, C., Lin, H., & Chen, J. (2015) · Nutrients · doi:10.3390/nu7064938 · Cited by 81

Resveratrol’ biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Sharifi-Rad, J., Quispe, C., Durazzo, A., Lucarini, M., Souto, E. B., Santini, A., Imran, M., Moussa, A. Y., Mostafa, N. M., El-Shazly, M., et al. (2022) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2022.100550 · Cited by 81

Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor‐mediated ERK1/2 activation to accelerate remyelination

Xiao, L., Guo, D., Hu, C., Shen, W., Shan, L., Li, C., Liu, X., Yang, W., Zhang, W., & He, C. (2012) · Glia · doi:10.1002/glia.22333 · Cited by 78

Structural analogues of diosgenyl saponins: Synthesis and anticancer activity

Kaskiw, M. J., Tassotto, M. L., Mok, M., Tokar, S. L., Pycko, R., Th'ng, J. P. H., & Jiang, Z. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.046 · Cited by 76

Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

Zhang, G., Zeng, X., Zhang, R., Liu, J., Zhang, W., Zhao, Y., Zhang, X., Wu, Z., Tan, Y., Wu, Y., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.07.003 · Cited by 76

Association of nutraceutical supplements with longer telomere length

Tsoukalas, D., Fragkiadaki, P., Docea, A. O., Alegakis, A. K., Sarandi, E., Vakonaki, E., Salataj, E., Kouvidi, E., Nikitovic, D., Kovatsi, L., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4191 · Cited by 76

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Liao, W., Lin, J.-Y., Shieh, J., Yeh, H.-F., Hsieh, Y., Cheng, Y.-C., Lee, H., Shen, C., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010172 · Cited by 76

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

Li, X., Liu, S., Qu, L., Chen, Y., Yuan, C., Qin, A., Liang, J., Huang, Q., Jiang, M., & Zou, W. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114018 · Cited by 73

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Popović‐Djordjević, J. B., Quispe, C., Giordo, R., Kostić, A. Ž., Stanković, J. S. K., Fokou, P. V. T., Carbone, K., Martorell, M., Kumar, M., Pintus, G., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114217 · Cited by 72

Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis

Yang, Q., Wang, C., Jin, Y., Ma, X., Xie, T., Wang, J., Liu, K., & Sun, H. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104414 · Cited by 71

Diosgenin from Dioscorea nipponica Ameliorates Diabetic Neuropathy by Inducing Nerve Growth Factor

Kang, T. H., Moon, E., Hong, B. N., Choi, S. Z., Son, M., Park, J. H., & Kim, S. Y. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1493 · Cited by 69

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L., Shariat‐Madar, Z., Helferich, W. G., Katzenellenbogen, B. S., & Dasmahapatra, A. K. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.12.001 · Cited by 68

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

Yang, S., Weng, C., Sethi, G., & Hu, D. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/698190 · Cited by 66

Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose

Chiu, C., Chiu, Y., Wu, L., Lu, T.-C., Huang, T.-H., Hsieh, M., Lu, C., & Peng, W. (2011) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x11009020 · Cited by 66

Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories

Dai, Z., Liu, Y., Sun, Z., Wang, D., Qu, G., Ma, X., Fan, F., Zhang, L., Li, S.-L., & Zhang, X. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.10.001 · Cited by 66

Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer.

Zlatian, O. M., Comanescu, M. V., Roşu, A. F., Roşu, L., Cruce, M., Găman, A. E., Călina, C. D., & Sfredel, V. (2015) · PubMed · Cited by 65

The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies

Calina, D., Buga, A. M., Mitroi, M., Buha, A., Caruntu, C., Scheau, C., Bouyahya, A., El Omari, N., El Menyiy, N., & Docea, A. O. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082395 · Cited by 65

Post-Concussion Syndrome and Chronic Traumatic Encephalopathy: Narrative Review on the Neuropathology, Neuroimaging and Fluid Biomarkers

Mavroudis, I. A., Kazis, D. A., Chowdhury, R., Petridis, F., Costa, V., Balmuș, I.-M., Ciobica, A. S., Luca, A.-C., Radu, I., Dobrin, R., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12030740 · Cited by 65

Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways

Hu, M., Xu, L., Yin, L., Qi, Y., Li, H., Xu, Y., Han, X., Peng, J., & Wan, X. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2715 · Cited by 64

Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats

Sato, K., Fujita, S., & Iemitsu, M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.02.020 · Cited by 64

Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces

Gupta, D. D., Mishra, S., Verma, S. S., Shekher, A., Rai, V., Awasthee, N., Das, T. J., Paul, D., Das, S. K., Tag, H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113842 · Cited by 64

Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells

Kim, E., Jang, J., Lee, Y., Sung, E., Song, I., Kim, J., Kim, S., Sohn, H.-Y., & Lee, T. J. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0994-z · Cited by 63

Diosgenin down-regulates NF- κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice

Gao, M., Chen, L., Yu, H., Sun, Q., Kou, J., & Yu, B. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2012.11.019 · Cited by 63

Comparison of ultrasound and microwave assisted extraction of diosgenin from Trigonella foenum graceum seed

Arya, P., & Kumar, P. (2021) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2021.105572 · Cited by 62

Atherogenic diet induced lipid accumulation induced NFκB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent

Binesh, A., Devaraj, S. N., & Devaraj, H. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.012 · Cited by 61

Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS

Tohda, C., Lee, Y., Goto, Y., & Nemere, I. (2013) · Scientific Reports · doi:10.1038/srep03395 · Cited by 60

Potent effects of dioscin against gastric cancer in vitro and in vivo

Zhao, X., Xu, L., Zheng, L., Yin, L., Qi, Y., Han, X., Xu, Y., & Peng, J. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.012 · Cited by 60

Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway

Zhao, X., Tao, X., Xu, L., Yin, L., Qi, Y., Xu, Y., Han, X., & Peng, J. (2016) · Molecules · doi:10.3390/molecules21060730 · Cited by 60

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

Leng, J., Li, X., Tian, H., Liu, C., Guo, Y., Zhang, S., Chu, Y., Li, J., Wang, Y., & Zhang, L. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02930-7 · Cited by 60

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

Manda, V. K., Avula, B., Ali, Z., Wong, Y.-H., Smillie, T. J., Khan, I. A., & Khan, S. I. (2013) · Planta Medica · doi:10.1055/s-0033-1350699 · Cited by 59

Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting the TLR/NF-κB Pathway

Li, B., Xu, P., Wu, S., Jiang, Z., Huang, Z., Li, Q., & Chen, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180330 · Cited by 59

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Rabha, B., Bharadwaj, K. K., Baishya, D., Sarkar, T., Edinur, H. A., & Pati, S. (2021) · Polymers · doi:10.3390/polym13081322 · Cited by 58

Modulatory Effects of Diosgenin on Attenuating the Key Enzymes Activities of Carbohydrate Metabolism and Glycogen Content in Streptozotocin-Induced Diabetic Rats

Saravanan, G., Ponmurugan, P., Deepa, M. A., & Senthilkumar, B. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.02.004 · Cited by 57

High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio

Zhang, Z., Song, C., Fu, X., Liu, M., Li, Y., Pan, J., Liu, H., Wang, S., Xiang, L., Xiao, G. G., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150917130 · Cited by 56

Diosgenin-induced autophagy and apoptosis in a human prostate cancer cell line

Nie, C., Zhou, J., Qin, X., Shi, X., Zeng, Q., Liu, J., Yan, S., & Zhang, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5750 · Cited by 56

Molecular and cellular stratagem of brain metastases associated with melanoma (Review)

Bugă, A. M., Docea, A. O., Albu, C. V., Mălin, R. D., Branisteanu, D. E., Ianoși, G., Ianoși, S. L., Iordache, A. M., & Călina, D. C. (2019) · Oncology Letters · doi:10.3892/ol.2019.9933 · Cited by 55

Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

Zhiyu, W., Cheng, Y., Wang, N., Mei, W. D., Li, W., Feng, H., Gang, S. J., Po, Y. D., Yuan, G. X., & Chen, J. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.13.3.18693 · Cited by 54

Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

Hernández-Vázquez, J. M. V., López‐Muñoz, H., Escobar-Sánchez, M. L., Flores-Guzmán, F., Weiss‐Steider, B., Hilario-Martínez, J. C., Sandoval-Ramı́rez, J., Fernández‐Herrera, M. A., & Sánchez, L. S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172942 · Cited by 54

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Scheau, C., Căruntu, C., Bădărău, I. A., Scheau, A.-E., Docea, A. O., Călina, D. C., & Căruntu, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060494 · Cited by 54

Renoprotective effect of diosgenin in streptozotocin induced diabetic rats

Kanchan, D. M., Somani, G. S., Peshattiwar, V., Kaikini, A., & Sathaye, S. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2015.10.011 · Cited by 53

Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer’s disease agents

Yang, G., Huang, Y., Zheng, L., Zhang, L., Su, L., Wu, Y., Li, J., Zhou, L., Huang, J. Y., Tang, Y., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111913 · Cited by 53

Diosgenin ameliorates gestational diabetes through inhibition of sterol regulatory element-binding protein-1

Hua, S., Li, Y., Su, L., & Liu, X. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.049 · Cited by 52

Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model

Zhu, S., Tang, S., & Su, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7900 · Cited by 52

Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization

Wang, S., Wang, F., Yang, H., Li, R., Guo, H., & Hu, L. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.008 · Cited by 50

A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis

Yang, H., Yin, H., Shen, Y., Xia, G., Zhang, B., Wu, X., Cai, B., & Tam, J. P. (2016) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2016.05.030 · Cited by 49

Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells

Liagre (2010) · International Journal of Oncology · doi:10.3892/ijo_00000601 · Cited by 48

Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α

Junchao, Y., Zhen, W., Wang, Y., Xu, L., Jiang, L., Yuanhong, Z., Zhao, W. L., Ruilin, C., & Lu, Z. (2016) · Journal of International Medical Research · doi:10.1177/0300060516676724 · Cited by 48

Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

Selim, S., & Jaouni, S. A. (2015) · Natural Product Research · doi:10.1080/14786419.2015.1065493 · Cited by 47

Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating Autophagy and Alleviating Apoptosis

Chen, X.-B., Wang, Z., Yang, Q., Zhao, F., Qin, X., Tang, X., Du, J.-L., Chen, Z.-H., Zhang, K., & Huang, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082274 · Cited by 47

i TRAQ ‐based proteomic analysis of dioscin on human HCT ‐116 colon cancer cells

Chen, H., Xu, L., Yin, L., Xu, Y., Han, X., Qi, Y., Zhao, Y., Liu, K., & Peng, J. (2013) · PROTEOMICS · doi:10.1002/pmic.201300101 · Cited by 46

Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin

Chang, H., Kao, M., Way, T., Ho, C., & Fu, E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200598w · Cited by 45

Targeting NFE2L2, a transcription factor upstream of MMP-2: A potential therapeutic strategy for temozolomide resistant glioblastoma

Rajesh, Y., Biswas, A., Kumar, U., Das, S., Banerjee, I., Banik, P., Bharti, R., Nayak, S., Ghosh, S. K., & Mandal, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.025 · Cited by 45

Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC‐ELSD

Avula, B., Wang, Y., Ali, Z., Smillie, T. J., & Khan, I. A. (2013) · Biomedical Chromatography · doi:10.1002/bmc.3019 · Cited by 44

Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta

Roghani, F., Roghani, M., & Baluchnejadmojarad, T. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000308 · Cited by 43

Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma

Chen, Z., Xu, J., Wu, Y., Lei, S., Liu, H., Meng, Q., & Xia, Z. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.022 · Cited by 43

Modification of cellulase and its application to extraction of diosgenin from Dioscorea zingiberensis C.H. Wright

Zhang, Y., Tang, L., An, X., Fu, E. H., & Ma, C. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.07.006 · Cited by 41

Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline

Cioboată, R., Găman, A. E., Trașcă, D.-M., Ungureanu, A. M., Docea, A. O., Tomescu, P. I., Gherghina, F. L., Arsene, A. L., Badiu, C., Tsatsakis, A. M., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4256 · Cited by 41

Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway

Wang, L., Du, J.-L., Zhao, F., Chen, Z., Chang, J., Qin, F., Wang, Z., Wang, F., Chen, X., & Chen, N. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.046 · Cited by 41

Osteoprotective Effect of Monascus-fermented Dioscorea in Ovariectomized Rat Model of Postmenopausal Osteoporosis

Chiang, S., Chang, S.-P., & Pan, T. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201640j · Cited by 40

Diosgenin Exerts Antitumor Activity via Downregulation of Skp2 in Breast Cancer Cells

Liu, Y., Zhou, Z., Yan, J., Wu, X., & Xu, G. (2020) · BioMed Research International · doi:10.1155/2020/8072639 · Cited by 40

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action

Yin, H., Zhang, M., An, R.-F., Zhou, J., Liu, W. Y., Morris-Natschke, S. L., Cheng, Y., Lee, K., & Huang, X. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00698 · Cited by 40

Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways

Ma, L., Zhang, J., Wang, X., Yang, J., Guo, L., Wang, X., Song, B., Dong, W., & Wang, W. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113361 · Cited by 40

Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism

Yang, R., Chen, W., Lu, Y. F., Li, Y., Du, H., Gao, S., Dong, X. W., & Yuan, H. (2017) · Scientific Reports · doi:10.1038/srep40035 · Cited by 39

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease

Chojnacki, J. E., Liu, K., Saathoff, J. M., & Zhang, S. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.10.032 · Cited by 38

Immunohistochemical expression of TGF beta (TGF-β), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas.

Docea, A. O., Mitruț, P., Grigore, D., Pirici, D., Călina, D. C., & Gofiţă, E. (2012) · PubMed · Cited by 38

Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum

Sharifi‐Rad, J., Quispe, C., Bouyahya, A., Menyiy, N. E., Omari, N. E., Shahinozzaman, M., Ovey, M. A. H., Koirala, N., Panthi, M., Ertani, A., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6727609 · Cited by 38

Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR

Ma, T., Wang, R., & Zou, X. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1360-1 · Cited by 37

Water-Soluble Arginyl–Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS

Cai, B., Seong, K.-J., Bae, S., Kook, M. S., Chun, C., Lee, J. H., Choi, W., Jung, J., & Kim, W.-J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1496-3 · Cited by 37

Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera

Yang, F., Liang, Y., Xu, L., Ji, L., Yao, N., Liu, R., Shi, L., & Liang, T. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.017 · Cited by 36

The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial

Nouri, K., Walch, K., Weghofer, A., Imhof, M., Egarter, C., & Ott, J. (2016) · Gynecologic and Obstetric Investigation · doi:10.1159/000452662 · Cited by 36

Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease

Cai, H., Wang, Z., Zhang, H., Wang, F., Yu, C., Zhang, F., Gao, L., Zhang, J., & Zhao, J. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.133 · Cited by 36

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Tsoukalas, D., Zlatian, O. M., Mitroi, M. R., Renieri, E. A., Tsatsakis, A. M., Izotov, B. N., Burada, F., Sosoi, S. S., Burada, E., Bugă, A. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040624 · Cited by 36

Synthesis, characterization and biological studies of diosgenyl analogues

Huang, B., Du, D., Zhang, R., Wu, X., Xing, Z., He, Y., & Huang, W. Q. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.10.086 · Cited by 35

Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats

Wang, P., He, L., Shen, G., Li, R., & Yang, J. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0341-4 · Cited by 35

Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain

Cheng, S., Ho, Y., Yu, S.-H., Liu, Y.-F., Lin, Y.-Y., Huang, C., Ou, H., Huang, H., & Lee, S. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500202 · Cited by 34

Saponins: the phytochemical with an emerging potential for curing clinical depression

Abbas, G., Rauf, K., & Mahmood, W. (2014) · Natural Product Research · doi:10.1080/14786419.2014.942661 · Cited by 33

Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats

Zhang, X., Xue, X., Zhao, J., Qian, C., Guo, Z., Ito, Y., & Sun, W.-J. (2016) · Steroids · doi:10.1016/j.steroids.2016.07.006 · Cited by 33

Expression of chemokines in macrophage polarization and downregulation of NFκB in aorta allow macrophage polarization by diosgenin in atherosclerosis

Binesh, A., Devaraj, S. N., & Devaraj, H. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22422 · Cited by 33

Identification of Polyphenols, Glycoalkaloids, and Saponins in Solanum scabrum Berries Using HPLC‐UV/Vis‐MS

Yuan, B., Byrnes, D., Dinssa, F. F., Simon, J. E., & Wu, Q. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14424 · Cited by 30

Dioscorea deltoidea wall. Ex Griseb: A review of traditional uses, bioactive compounds and biological activities

Semwal, P., Painuli, S., & Martins, N. A. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.100969 · Cited by 30

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury

Zhao, W.-X., Wang, P., Song, H.-G., & Sun, N. C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6723 · Cited by 29

Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis

Mao, X., Zhou, P., Li, S., Zhang, X., Shen, J.-X., Qing-xi, C., Zhuang, J.-X., & Shen, D. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s226261 · Cited by 29

Diosgenin inhibits the expression of NEDD4 in prostate cancer cells.

Zhang, J., Xie, J., Zhou, S., Chen, J., Hu, Q., Pu, J., & Lu, J. (2019) · PubMed Central · Cited by 29

ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease

Siokas, V., Aloizou, A.-M., Tsouris, Z., Liampas, I., Liakos, P., Calina, D., Docea, A. O., Tsatsakis, A., Bogdanos, D. P., Hadjigeorgiou, G. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030381 · Cited by 29

Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

Hossain, R., Quispe, C., Herrera‐Bravo, J., Beltrán, J. F., Islam, M. T., Shaheen, S., Martins, N. A., Martorell, M., Kumar, M., Sharifi‐Rad, J., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3079577 · Cited by 29

Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L

Deshpande, H. A., & Bhalsing, S. R. (2013) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-013-0205-3 · Cited by 28

Yam (Dioscorea pseudojaponicaYamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose

Chiu, C., Deng, J., Hsieh, M., Fan, M., Lee, M., Chueh, F., Han, C., Lin, Y.-C., & Peng, W. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09007296 · Cited by 28

Spectrophotometric determination of diosgenin in Dioscorea composita following thin-layer chromatography

Sánchez, G. L., Acevedo, J. C. M., & Soto, R. R. (1972) · The Analyst · doi:10.1039/an9729700973 · Cited by 28

Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo

Zheng, H., Wei, Z., Xin, G., Ji, C., Wen, L., Xia, Q., Niu, H., & Huang, W. Q. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.032 · Cited by 28

Characterization of ADME Properties of Diosgenin and Dioscin: Bioactive Constituents of Dioscorea villosa (Wild yam)

Manda, V., Avula, B., Ali, Z., Smillie, T., Khan, I., & Khan, S. I. (2013) · Planta Medica · doi:10.1055/s-0033-1336521 · Cited by 27

An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease

Aaron, P. A., Vu, K., & Gelli, A. (2020) · mBio · doi:10.1128/mbio.01249-20 · Cited by 27

Diosgenin increased DDX3 expression in hepatocellular carcinoma.

Yu, H., Liu, Y., Niu, C., & Cheng, Y. (2018) · Europe PMC (PubMed Central) · Cited by 26

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Cai, D., Qi, J., Yang, Y., Zhang, W., Zhou, F., Jia, X., Guo, W., Huang, X., Gao, F., Chen, H., et al. (2019) · Molecules · doi:10.3390/molecules24224025 · Cited by 26

Protective role of diosgenin against hyperglycaemia-mediated cerebral ischemic brain injury in zebrafish model of type II diabetes mellitus

Akinsipo, O. B., Dare, E. O., & Katare, D. P. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03296 · Cited by 26

Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines

Stefanowicz‐Hajduk, J., Król-Kogus, B., Sparzak-Stefanowska, B., Kimel, K., Ochocka, J. R., & Krauze‐Baranowska, M. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1903047 · Cited by 25

Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice

Kim, J. E., Go, J., Koh, E. K., Song, S. H., Sung, J. E., Lee, H. A., Kim, D. S., Son, H. J., Lee, H. S., Lee, C. Y., et al. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1135040 · Cited by 24

Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets

Zhang, X., Wang, X., Xue, Z., Zhan, G., Ito, Y., & Guo, Z. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128672 · Cited by 24

HPTLC quantification of diosgenin in Dioscorea deltoidea: Evaluation of extraction efficacy, organ selection, drying method and seasonal variation

Nazir, R., Kumar, V., Dey, A., & Pandey, D. K. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2020.12.027 · Cited by 24

Diosgenin attenuates hepatic stellate cell activation through transforming growth factor-β/Smad signaling pathway.

Xie, W., Jiang, R., Shen, X., Chen, Z., & Deng, X. (2015) · PubMed Central · Cited by 22

Colorectal Cancer and Inflammatory Bowel Disease

Mitruț, P., Docea, A. O., Kamal, A. M., Mitruţ, R., Călina, D. C., Gofiţă, E., Pădureanu, V., Gruia, C. L., & Streba, L. (2016) · InTech eBooks · doi:10.5772/63408 · Cited by 22

Diosgenin improves functional recovery from sciatic crushed nerve injury in rats

Lee, B.-K., Kim, C., Shin, M., & Cho, Y. S. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836340.170 · Cited by 22

Investigation on the mechanisms for biotransformation of saponins to diosgenin

Zhu, Y., Zhu, H., Qiu, M., Zhu, T., & Ni, J. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1429-7 · Cited by 21

Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity

Martínez-Gallegos, A. A., Guerrero‐Luna, G., Ortiz-González, A., Cárdenas-García, M., Bernès, S., & Hernández-Linares, M. G. (2020) · Steroids · doi:10.1016/j.steroids.2020.108777 · Cited by 21

Diosgenin inhibits angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts through regulating the TGF-β1/Smad3 signaling pathway

Zhou, H.-T., Yu, X., & Zhou, G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6280 · Cited by 20

Therapeutic effects of diosgenin in experimental autoimmune encephalomyelitis.

Liu, W., Zhu, M., Yu, Z., Yin, D., Lu, F., Pu, Y.-Y., Zhao, C., He, C., & Cao, L. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.018 · Cited by 18

Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells

Sun, G., Jan, C., & Liang, W. (2019) · Environmental Toxicology · doi:10.1002/tox.22876 · Cited by 17

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Koh, E.-K., Yun, W.-B., Kim, J.-E., Song, S., Sung, J.-E., Lee, H. A., Seo, E.-J., Jee, S. W., Bae, C.-J., & Hwang, D. Y. (2016) · Laboratory Animal Research · doi:10.5625/lar.2016.32.2.105 · Cited by 16

The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study

Cai, T., Cocci, A., Cito, G., Giammusso, B., Zucchi, A., Chianchone, F., Carrino, M., Mastroeni, F., Comerci, F., Franco, G., et al. (2018) · Archivio Italiano di Urologia e Andrologia · doi:10.4081/aiua.2018.1.59 · Cited by 15

The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells

Chun, J., Han, L., Xu, M. Y., Wang, B., Cheng, M. S., & Kim, Y. S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0279-z · Cited by 14

Minireview on the Connections between the Neuropsychiatric and Dental Disorders: Current Perspectives and the Possible Relevance of Oxidative Stress and Other Factors

Ciobica, A. S., Pădurariu, M., Curpăn, A.-Ș., Antioch, I., Chiriță, R., Ștefănescu, C., Luca, A.-C., & Tomida, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6702314 · Cited by 13

Effect of extract of Trillium tschonoskii Maxim on ciliary neurotropic factor and its receptor α in rats suffering from spinal cord injury

Chen, X., Zhu, M.-Y., Qin, F.-R., Tang, S.-Q., Wang, F., Long, B.-L., & Yuan, D.-P. (2015) · Jiefangjun yixue zazhi · Cited by 6

[Protective effect of diosgenin on chondrocytes mediated by JAK2/STAT3 signaling pathway in mice with osteoarthritis].

Liu, J., He, X., Zhen, P., Zhou, S., & Li, X. (2016) · PubMed Central · doi:10.3785/j.issn.1008-9292.2016.09.02 · Cited by 6

Designing and optimizing a parallel neural network model for predicting the solubility of diosgenin in n-alkanols

Lv, H., & Tian, D. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.09.009 · Cited by 3

Quantitative Analysis of (+)-Catechin and Diosgenin from Smilax china L. Rhizome

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