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Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
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contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin's pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin's nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin's safety profile.
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“The worldwide increasing tendency toward using phytochemicals may be due to low toxicity, and synergistic effects [199,200,201].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [200]
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“Many naturally occurring substances such as resveratrol, neoechinulins, genistein or diosgenin provided antioxidant, anti-inflammatory, chelating, and/or scavenger activity [115,200,224,225].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [200]
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Metadata
- Authors
- Semwal, P., Painuli, S., Abu-Izneid, T., Rauf, A., Sharma, A., Daştan, S. D., Kumar, M., Alshehri, M. M., Taheri, Y., Das, R., Mitra, S., Emran, T. B., Sharifi-Rad, J., Calina, D., & Cho, W. C.
- Affiliations
- Graphic Era University (IN)
- University of Swabi (PK)
- Dr. Yashwant Singh Parmar University of Horticulture and Forestry (IN)
- Sivas Cumhuriyet Üniversitesi (TR)
- ICAR - Central Institute for Research on Cotton Technology (IN)
- National Guard Health Affairs (SA)
- Shahid Beheshti University (IR)
- University of Dhaka (BD)
- Daffodil International University (BD)
- Queen Elizabeth Hospital (CN)
- Corresponding author
- Semwal, Prabhakar
- Rauf, Abdur
- Cho, William C.
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2022-01
- Volume
- 2022
- Issue
- 1
- Pages
- 1035441-1035441
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC9168095
- OpenAlex
- W4281667219
- Cited by
- 195
- References
- 167
- Citations by year
- 2026: 46 · 2025: 44 · 2024: 49 · 2023: 37 · 2022: 18
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
- Keywords
- diosgenin, steroidal sapogenins, pharmacological activity, cancer, diabetes mellitus, arthritis, asthma, cardiovascular disease, neuroprotection, atherosclerosis, bone health, cognitive function, menopause, drug safety
- MeSH terms
- Asthma, Diosgenin, Humans, Neoplasms, Plant Extracts, Trigonella, Phytochemicals
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