The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway
Open accessAbstract
Osteosarcoma (OS) is a primary malignancy of bone with a tendency to metastasize early. Despite intensive chemotherapy and surgical resection, ∼30% of patients still develop distant metastasis. Our previous work using clinical OS samples suggested that expression of the Wnt receptor LRP5 might be associated with tumor metastasis. In the present study, we used a Dickkopf (Dkk) family member and a dominant-negative LRP5 receptor construct to modulate Wnt signaling in OS cells. Saos-2 cells, which ectopically express Dkk-3, do not undergo apoptosis and exhibit enhanced resistance to serum starvation and chemotherapy-induced cytotoxicity. Transfection of Dkk-3 and dominant-negative LRP5 into Saos-2 cells significantly reduces invasion capacity and cell motility. This blockade is associated with changes in cell morphology consistent with a less invasive phenotype. In addition, Dkk-3 and dominant-negative LRP5 also induce changes in β-catenin localization consistent with an increase in cell-cell adhesion. Taken together, these results support a possible role for Wnt signaling in the pathobiology and progression of human OS.
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Cites
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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
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Tissue repair and stem cell renewal in carcinogenesis
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Function and biological roles of the Dickkopf family of Wnt modulators
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Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
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Self-citationThe Regulation of Bone Metabolism and Disorders by Wnt Signaling
Maeda, K., Kobayashi, Y., Koide, M., Uehara, S., Okamoto, M., Ishihara, A., Kayama, T., Saito, M., & Marumo, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225525 · Cited by 353
Metadata
- Authors
- Hoang, B. H., Kubo, T., Healey, J. H., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Meyers, P. A., & Gorlick, R.
- Venue
- Cancer Research
- Published
- 2004-04-15
- Volume
- 64
- Issue
- 8
- Pages
- 2734-2739
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2054956467
- Cited by
- 261
- References
- 36
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway. https://app.cochat.ai/papers/10.1158/0008-5472.can-03-1952
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- Hoang, B. H., Kubo, T., Healey, J. H., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Meyers, P. A., & Gorlick, R. (2004). Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway. Cancer Research. https://doi.org/10.1158/0008-5472.can-03-1952
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