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Role of Macrophage Inhibitory Cytokine-1 in Tumorigenesis and Diagnosis of Cancer
Open accessAbstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
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“Growth differentiation factor 15 (GDF15), also called macrophage inhibitory cytokine-1, is associated with numerous biological processes and diseases including cancer, cardiovascular disease, and obesity [[199], [200], [201], [202]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [199]
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Metadata
- Authors
- Bauskin, A. R., Brown, D. A., Kuffner, T., Johnen, H., Luo, X. W., Hunter, M., & Breit, S. N.
- Affiliations
- UNSW Sydney (AU)
- Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia
- Venue
- Cancer Research
- Published
- 2006-05-15
- Volume
- 66
- Issue
- 10
- Pages
- 4983-4986
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2020474446
- Cited by
- 251
- References
- 27
- Citations by year
- 2025: 8 · 2024: 13 · 2023: 14 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 12
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- MIC-1, TGF-beta superfamily, carcinogenesis, cancer diagnosis, tumor microenvironment, tumor progression, tumor invasion
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Biomarkers, Tumor, Cytokines, Growth Differentiation Factor 15
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