The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Role of Macrophage Inhibitory Cytokine-1 in Tumorigenesis and Diagnosis of Cancer
Open accessAbstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
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“Growth differentiation factor 15 (GDF15), also called macrophage inhibitory cytokine-1, is associated with numerous biological processes and diseases including cancer, cardiovascular disease, and obesity [[199], [200], [201], [202]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [199]
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MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180
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Self-citationMIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation
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Self-citationMIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma.
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Research works printed but not linked: 1
- Liu T, Bauskin AR, Zaunders J, et al. MIC-1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res 2003; 63: 5034–40.
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Metadata
- Authors
- Bauskin, A. R., Brown, D. A., Kuffner, T., Johnen, H., Luo, X. W., Hunter, M., & Breit, S. N.
- Affiliations
- UNSW Sydney (AU)
- Centre for Immunology, St. Vincent's Hospital and University of New South Wales, Sydney, Australia
- Venue
- Cancer Research
- Published
- 2006-05-15
- Volume
- 66
- Issue
- 10
- Pages
- 4983-4986
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2020474446
- Cited by
- 251
- References
- 27
- Citations by year
- 2025: 8 · 2024: 13 · 2023: 14 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 13 · 2018: 6 · 2017: 13 · 2016: 15 · 2015: 12 · 2014: 16 · 2013: 13 · 2012: 12
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- MIC-1, TGF-beta superfamily, carcinogenesis, cancer diagnosis, tumor microenvironment, tumor progression, tumor invasion
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Biomarkers, Tumor, Cytokines, Growth Differentiation Factor 15
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