The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma
Open accessAbstract
We investigated the role of microRNAs (miRNAs) in the pathogenesis of human hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify differentially expressed miRNAs in HCCs arisen on cirrhotic livers. Thirty-five miRNAs were identified. Several of these miRNAs were previously found deregulated in other human cancers, such as members of the let-7 family, mir-221, and mir-145. In addition, the hepato-specific miR-122a was found down-regulated in ∼70% of HCCs and in all HCC-derived cell lines. Microarray data for let-7a, mir-221, and mir-122a were validated by Northern blot and real-time PCR analysis. Understanding the contribution of deregulated miRNAs to cancer requires the identification of gene targets. Here, we show that miR-122a can modulate cyclin G1 expression in HCC-derived cell lines and an inverse correlation between miR-122a and cyclin G1 expression exists in primary liver carcinomas. These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer. [Cancer Res 2007;67(13):6092–9]
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Self-citationSilencing of microRNAs in vivo with ‘antagomirs’
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Cited by
Coulouarn, C., Factor, V. M., Andersen, J. B., Durkin, M. E., & Thorgeirsson, S. S. (2009) · Oncogene · doi:10.1038/onc.2009.211 · Cited by 733
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Inhibition of microRNA function by antimiR oligonucleotides
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Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma
Sohn, W., Kim, J., Kang, S. H., Yang, S. R., Cho, J.-Y., Cho, H. C., Shim, S. G., & Paik, Y.-H. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.68 · Cited by 426
Metadata
- Authors
- Gramantieri, L., Ferracin, M., Fornari, F., Veronese, A., Sabbioni, S., Liu, C.-G., Calin, G. A., Giovannini, C., Ferrazzi, E., Grazi, G. L., Croce, C. M., Bolondi, L., & Negrini, M.
- Venue
- Cancer Research
- Published
- 2007-07-01
- Volume
- 67
- Issue
- 13
- Pages
- 6092-6099
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2107515690
- Cited by
- 813
- References
- 7
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma. https://app.cochat.ai/papers/10.1158/0008-5472.can-06-4607
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- Gramantieri, L., Ferracin, M., Fornari, F., Veronese, A., Sabbioni, S., Liu, C.-G., Calin, G. A., Giovannini, C., Ferrazzi, E., Grazi, G. L., Croce, C. M., Bolondi, L., & Negrini, M. (2007). Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.can-06-4607
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