Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer
Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
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TAMs are found largely in hypoxic tumor regions and drive angiogenic response required for tumor survival and metastasis.
“Interestingly, TAMs are found largely within hypoxic regions of tumors and have been shown drive the angiogenic response that is required for tumor survival and metastasis [40,41].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [41]
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“Genetic gain-of-function of VEGFA over a loss-of function of CSF1 in the PyMT mouse model also resulted in a dramatic recruitment of macrophages and a rescue of angiogenesis that resulted in an acceleration of tumor progression to malignancy (Lin et al., 2007).”
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- Authors
- Lin, E. Y., & Pollard, J. W.
- Affiliations
- Albert Einstein College of Medicine (US)
- Yeshiva University (US)
- Venue
- Cancer Research
- Published
- 2007-06-01
- Volume
- 67
- Issue
- 11
- Pages
- 5064-5066
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2112057120
- Cited by
- 463
- References
- 2
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 19 · 2022: 25 · 2021: 27 · 2020: 33 · 2019: 20 · 2018: 17 · 2017: 30 · 2016: 25 · 2015: 29 · 2014: 22 · 2013: 29 · 2012: 30
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P-30-CA13330, CA 94173, P01CA100324, R01CA094173, CA 100324, P30CA013330)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor-associated macrophages, breast cancer, angiogenic switch, tumor vasculature, microvessel density, malignant transformation, macrophage recruitment, prognosis, tumor microenvironment
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Macrophages, Mammary Neoplasms, Experimental, Mice, Transgenic, Neovascularization, Pathologic, Mice
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