Cited by 276Immune cells in cancerAngiogenesis and VEGF in CancerCancer Cells and Metastasis

Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer

Tang, Xiaoqiang·2013·Cancer Letters

Abstract

Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and facilitate tumor development. Clinical evidences compellingly indicate the association between high TAMs influx and poor prognosis in patients with breast cancers. The pan-macrophage marker CD68 is now generally utilized to identify TAMs in diagnostic biopsy samples, and some other TAM-related biomarkers are also utilized in prognosis prediction, including CD163, vascular endothelial growth factor (VEGF), hypoxia-inducible factors (HIFs), proliferating cellular nuclear antigen (PCNA), ferritin light chain (FTL) and C-C motif chemokine ligand 18 (CCL18). In this review, we highlight the recent progress made in understanding the relationship between TAMs and clinicopathological parameters in human breast cancer and address the potential value of TAMs as diagnostic and prognostic biomarkers.

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Crossref · 10.1016/j.canlet.2013.01.024

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  • The appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis.

    “Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”

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Authors
Tang, X.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
Tang, Xiaoqiang
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2013-05
Volume
332
Issue
1
Pages
3-10
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2077731584
Cited by
276
References
92
Citations by year
2026: 4 · 2025: 10 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 30 · 2019: 24 · 2018: 21 · 2017: 26 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 9
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Tsinghua University
  • West China Hospital, Sichuan University
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
tumor-associated macrophages, breast cancer, tumor microenvironment, M2 macrophages, CD68, prognostic factors, diagnostic biomarkers, CD163, vascular endothelial growth factor, hypoxia-inducible factor, PCNA, ferritin light chain, CCL18, TAM infiltration
MeSH terms
CD68 Molecule, Animals, Biopsy, Breast Neoplasms, Female, Humans, Macrophages, Predictive Value of Tests, Prognosis, Biomarkers, Tumor, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Tumor Microenvironment

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