Cited by 381Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismCancer, Lipids, and Metabolism

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Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

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Dang, Chi V.·2010·Cancer Research

DOI 10.1158/0008-5472.can-09-3556PMC PMC2818441

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Abstract

The MYC oncogene, which is frequently deregulated in human cancers, encodes a master transcription factor c-Myc (herein termed Myc) that integrates cell proliferation with metabolism through its regulation of thousands of genes including microRNAs (miRNA). In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b. These observations suggest an additional level of complexity in tumor metabolism, which includes the commensal metabolic relationship between hypoxic and nonhypoxic regions of tumors as well as the surrounding stroma. Thus, a reevaluation of cancer metabolism considering glutamine catabolism with a better understanding of the tumor histological complexity is needed before cancer metabolism can be effectively targeted in therapy. Cancer Res; 70(3); 859–62

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Authors: Dang, C. V.
Affiliations: Johns Hopkins University (US)
Corresponding author: Dang, Chi V.
ORCID: Dang, Chi V.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2010-01-31
Volume: 70
Issue: 3
Pages: 859-862
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-09-3556
PMC: PMC2818441
OpenAlex: W2070371419
Cited by: 379
References: 20
Citations by year: 2026: 1 · 2025: 7 · 2024: 11 · 2023: 15 · 2022: 14 · 2021: 17 · 2020: 22 · 2019: 18 · 2018: 26 · 2017: 24 · 2016: 35 · 2015: 33 · 2014: 36 · 2013: 36 · 2012: 41
FWCI: 12.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA 57341, R01CA057341, CA 51497, R37CA051497, R01CA051497)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: Warburg effect, MYC oncogene, glutamine metabolism, glutamine catabolism, microRNA repression, miR-23a, miR-23b, cancer metabolism, tumor hypoxia, tumor stroma
MeSH terms: Animals, Citric Acid Cycle, Glucose, Glutamine, Humans, Mitochondria, Models, Biological, Neoplasms, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, MicroRNAs

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Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

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