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Cisplatin Resistance Associated with PARP Hyperactivation
Published version of a preprint
Abstract
Non–small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin. Cells manifesting elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PARhigh) responded to pharmacologic PARP inhibitors as well as to PARP1-targeting siRNAs by initiating a DNA damage response that translated into cell death following the activation of the intrinsic pathway of apoptosis. Moreover, PARP1-overexpressing tumor cells and xenografts displayed elevated levels of PAR, which predicted the response to PARP inhibitors in vitro and in vivo more accurately than PARP1 expression itself. Thus, a majority of CDDP-resistant cancer cells appear to develop a dependency to PARP1, becoming susceptible to PARP inhibitor–induced apoptosis. Cancer Res; 73(7); 2271–80. ©2013 AACR.
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“However, mitotic catastrophe appears to constitute a major mechanism of action of anticancer chemotherapeutics, mostly reflecting the increased resistance of neoplastic cells to the induction of intrinsic apoptosis [1004–1009].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [1005]
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Metadata
- Authors
- Michels, J., Vitale, I., Galluzzi, L., Adam, J., Olaussen, K. A., Kepp, O., Senovilla, L., Talhaoui, I., Guegan, J., Enot, D. P., Talbot, M., Robin, A., Girard, P., Oréar, C., Lissa, D., Sukkurwala, A. Q., Garcia, P., Behnam-Motlagh, P., Kohno, K., Wu, G. S., Brenner, C., Dessen, P., Saparbaev, M., Soria, J.-C., Castedo, M., & Kroemer, G.
- Affiliations
- Université Paris-Sud (FR)
- Authors' Affiliations: 1U848, 2U981, 3U985, INSERM; 4Institut Gustave Roussy; 5Université Paris Sud; 6UMR8200, CNRS; Plateformes de 7Bioinformatique, 8Génomique, and 9Metabolomique, Institut Gustave Roussy; Villejuif; 10Université Paris Descartes; 11Department of Thoracic Oncology, Institut Mutualiste Montsouris; 12Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers; 13Pôle de Biologie, Hôpital Européen Georges Pompidou AP-HP, Paris; 14U769, INSERM-LabEx LERMIT, Université Paris-Sud, Châtenay Malabry, France; 15Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden; 16Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu/Fukuoka, Japan; and 17Molecular Therapeutics Program, Karmanos Cancer Institute, Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, Michigan
- ORCID
- Venue
- Cancer Research
- Published
- 2013-04-01
- Volume
- 73
- Issue
- 7
- Pages
- 2271-2280
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2060534647
- Cited by
- 176
- References
- 47
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 15 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 15 · 2016: 17 · 2015: 19 · 2014: 18 · 2013: 8
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- cisplatin resistance, PARP1, PARP inhibitors, non-small cell lung cancer, DNA damage response, mitochondrial apoptosis, poly(ADP-ribosyl)ation, siRNA knockdown, xenografts, chemoresistance
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase-1, Animals, Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Cisplatin, Female, Humans, Lung Neoplasms, Mice, Nude, Phenanthrenes, Poly(ADP-ribose) Polymerases, RNA, Messenger, Tumor Cells, Cultured, Blotting, Western, Apoptosis, Drug Resistance, Neoplasm, Reverse Transcriptase Polymerase Chain Reaction, Xenograft Model Antitumor Assays, Cell Proliferation, Mice, Real-Time Polymerase Chain Reaction
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