Cited by 130Estrogen and related hormone effectsGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

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Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level

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Miranda, Tina B., Voss, Ty C., Sung, Myong-Hee, Baek, Songjoon, John, Sam, Hawkins, Mary, Grøntved, Lars, Schiltz, R. Louis, Hager, Gordon L.·2013·Cancer Research

DOI 10.1158/0008-5472.can-13-0742PMC PMC3799864

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Abstract

Cross-talk between estrogen receptors (ER) and glucocorticoid receptors (GR) has been shown to contribute to the development and progression of breast cancer. Importantly, the ER and GR status in breast cancer cells is a significant factor in determining the outcome of the disease. However, mechanistic details defining the cellular interactions between ER and GR are poorly understood. We investigated genome-wide binding profiles for ER and GR upon coactivation and characterized the status of the chromatin landscape. We describe a novel mechanism dictating the molecular interplay between ER and GR. Upon induction, GR modulates access of ER to specific sites in the genome by reorganization of the chromatin configuration for these elements. Binding to these newly accessible sites occurs either by direct recognition of ER response elements or indirectly through interactions with other factors. The unveiling of this mechanism is important for understanding cellular interactions between ER and GR and may represent a general mechanism for cross-talk between nuclear receptors in human disease. Cancer Res; 73(16); 5130–9. ©2013 AACR.

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Self-citation
Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming
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Authors: Miranda, T. B., Voss, T. C., Sung, M.-H., Baek, S., John, S., Hawkins, M., Grøntved, L., Schiltz, R. L., & Hager, G. L.
Affiliations: National Institutes of Health (US)
Corresponding author: Hager, Gordon L.
ORCID: Miranda, Tina B.
Sung, Myong-Hee
Baek, Songjoon
Grøntved, Lars
Schiltz, R. Louis
Hager, Gordon L.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2013-08-13
Volume: 73
Issue: 16
Pages: 5130-5139
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-13-0742
PMC: PMC3799864
OpenAlex: W2109796629
Cited by: 130
References: 41
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 15 · 2020: 6 · 2019: 14 · 2018: 13 · 2017: 14 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 4
FWCI: 6.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Lundbeckfonden
National Institutes of Health
National Cancer Institute (Z01BC005450)
National Institute of General Medical Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: estrogen receptor, glucocorticoid receptor, chromatin accessibility, chromatin reorganization, breast cancer, transcriptional regulation
MeSH terms: Animals, Binding Sites, Cell Line, Chromatin, DNA, Protein Binding, Receptors, Estrogen, Receptors, Glucocorticoid, Genome, Response Elements, Mice

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Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level

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