The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Real-time Liquid Biopsy in Cancer Patients: Fact or Fiction?
Open accessAbstract
Distant metastases harbor unique genomic characteristics not detectable in the corresponding primary tumor of the same patient and metastases located at different sites show a considerable intrapatient heterogeneity. Thus, the mere analysis of the resected primary tumor alone (current standard practice in oncology) or, if possible, even reevaluation of tumor characteristics based on the biopsy of the most accessible metastasis may not reveal sufficient information for treatment decisions. Here, we propose that this dilemma can be solved by a new diagnostic concept: liquid biopsy, that is, analysis of therapeutic targets and drug resistance–conferring gene mutations on circulating tumor cells (CTC) and cell-free circulating tumor DNA (ctDNA) released into the peripheral blood from metastatic deposits. We discuss the current challenges and future perspectives of CTCs and ctDNA as biomarkers in clinical oncology. Both CTCs and ctDNA are interesting complementary technologies that can be used in parallel in future trials assessing new drugs or drug combinations. We postulate that the liquid biopsy concept will contribute to a better understanding and clinical management of drug resistance in patients with cancer. Cancer Res; 73(21); 6384–8. ©2013 AACR.
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Cites
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
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Dissemination and growth of cancer cells in metastatic sites
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Cell-free nucleic acids as biomarkers in cancer patients
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Self-citationCirculating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Yu, M., Bardia, A., Wittner, B. S., Stott, S. L., Smas, M. E., Ting, D. T., Isakoff, S. J., Ciciliano, J. C., Wells, M. N., Shah, A. M., et al. (2013) · Science · doi:10.1126/science.1228522 · Cited by 2,476
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
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The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
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Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
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Cited by
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Alix-Panabières, C., & Pantel, K. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1483 · Cited by 1,394
Self-citationChallenges in circulating tumour cell research
Alix-Panabières, C., & Pantel, K. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3820 · Cited by 1,300
Self-citationEmerging role of deep learning‐based artificial intelligence in tumor pathology
Jiang, Y., Yang, M., Wang, S., Li, X., & Sun, Y. (2020) · Cancer Communications · doi:10.1002/cac2.12012 · Cited by 438
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Brooks, M. D., Burness, M. L., & Wicha, M. S. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.08.014 · Cited by 374
Frequent expression of PD‐L1 on circulating breast cancer cells
Mazel, M., Jacot, W., Pantel, K., Bartkowiak, K., Topart, D., Cayrefourcq, L., Rossille, D., Maudelonde, T., Fest, T., & Alix-Panabières, C. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.05.009 · Cited by 374
Self-citation
Metadata
- Authors
- Pantel, K., & Alix-Panabières, C.
- Venue
- Cancer Research
- Published
- 2013-10-31
- Volume
- 73
- Issue
- 21
- Pages
- 6384-6388
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2140497649
- Cited by
- 409
- References
- 42
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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