Cited by 123Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer

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Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.

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Gopinathan, Lakshmi, Tan, Shawn Lu Wen, Padmakumar, V. C., Coppola, Vincenzo, Tessarollo, Lino, Kaldis, Philipp·2014·Cancer Research

DOI 10.1158/0008-5472.can-13-3440PMC PMC4102624

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Abstract

Cell-cycle inhibition has yet to offer a generally effective approach to cancer treatment, but a full evaluation of different combinations of cell-cycle inhibitors has not been evaluated. Cyclin A2, a core component of the cell cycle, is often aberrantly expressed in cancer where it may impact cell proliferation. In this study, we investigated the role of cyclin A2 in tumorigenesis using a conditional genetic knockout mouse model. Cyclin A2 deletion in oncogene-transformed mouse embryonic fibroblasts (MEF) suppressed tumor formation in immunocompromised mice. These findings were confirmed in mice with cyclin A2-deficient hepatocytes, where a delay in liver tumor formation was observed. Because cyclin A2 acts in complex with Cdk2 in the cell cycle, we explored a hypothesized role for Cdk2 dysregulation in this effect through conditional deletions of both genes. In oncogene-transformed MEFs lacking both genes, tumor formation was strongly suppressed in a manner associated with decreased proliferation, premature senescence, and error-prone recovery from serum deprivation after immortalization. Whereas loss of cyclin A2 led to a compensatory increase in Cdk1 activity, this did not occur with loss of both Cdk2 and cyclin A2. Our work offers a rationale to explore combinations of Cdk1 and Cdk2 inhibitors as a general approach in cancer therapy.

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Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Cell cycle, CDKs and cancer: a changing paradigm
Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · cited 1×
“Aberrant expression of cyclin A2 has been detected in a variety of cancers, and deregulation of cyclin A2 appears to be closely related to chromosomal instability and tumor proliferation (3, 12, 13).”
QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES
Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747
Cyclin A is required at two points in the human cell cycle.
Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. J., & Draetta, G. F. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05135.x · Cited by 1,403
A Highly Efficient Escherichia coli-Based Chromosome Engineering System Adapted for Recombinogenic Targeting and Subcloning of BAC DNA
Lee, E.-C., Yu, D., de Velasco, J. M., Tessarollo, L., Swing, D. A., Court, D. L., Jenkins, N. A., & Copeland, N. G. (2001) · Genomics · doi:10.1006/geno.2000.6451 · Cited by 1,180
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Rodríguez, C. I., Buchholz, F., Galloway, J. L., Sequerra, R., Kasper, J. S., Ayala, R., Stewart, A. F., & Dymecki, S. M. (2000) · Nature Genetics · doi:10.1038/75973 · Cited by 1,162
Cyclin a is required for the onset of DNA replication in mammalian fibroblasts
Girard, F., Strausfeld, U. P., Fernandez, A., & Lamb, N. J. C. (1991) · Cell · doi:10.1016/0092-8674(91)90293-8 · Cited by 880
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
Ortega, S., Priéto, I., Odajima, J., Martín, A. L., Dubus, P. R., Sotillo, R., Barbero, J. L., Malumbres, M., & Barbacid, M. (2003) · Nature Genetics · doi:10.1038/ng1232 · Cited by 798
Cdk2 Knockout Mice Are Viable
Berthet, C., Aleem, E. A., Coppola, V., Tessarollo, L., & Kaldis, P. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.024 · Cited by 665
Mouse development and cell proliferation in the absence of D-cyclins
Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647

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Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Biological Research · doi:10.1186/s40659-016-0095-2 · Cited by 39
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Guo, F., Zhang, K., Li, M., Cui, L., Liu, G., Yan, Y., Tian, W., Teng, F., Zhang, Y., Gao, C., et al. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5055 · Cited by 37
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Authors: Gopinathan, L., Tan, S. L. W., Padmakumar, V. C., Coppola, V., Tessarollo, L., & Kaldis, P.
Affiliations: Agency for Science, Technology and Research (SG)
National Cancer Institute (US)
Corresponding author: Kaldis, Philipp
ORCID: Tan, Shawn Lu Wen
Coppola, Vincenzo
Tessarollo, Lino
Kaldis, Philipp
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2014-07-14
Volume: 74
Issue: 14
Pages: 3870-3879
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-13-3440
PMC: PMC4102624
OpenAlex: W2166466732
Cited by: 123
References: 36
Citations by year: 2026: 3 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 15 · 2021: 22 · 2020: 14 · 2019: 16 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 2
FWCI: 3.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: American Association for Cancer Research
National Institutes of Health
Institute of Molecular and Cell Biology
Biomedical Research Council
National Cancer Institute (Z01SC010367)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: cyclin A2, CDK2, CDK1, cell cycle, carcinogenesis, cell proliferation, premature senescence, hepatocellular carcinoma, cell cycle inhibitors, conditional knockout mice
MeSH terms: Animals, Cell Transformation, Neoplastic, Disease Models, Animal, Enzyme Activation, Fibroblasts, Liver Neoplasms, CDC2 Protein Kinase, Cellular Senescence, Gene Deletion, Tumor Burden, Cell Proliferation, Cyclin-Dependent Kinase 2, Mice, Gene Knockdown Techniques, Cyclin A2

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Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.

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