Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.
Open accessAbstract
The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and tumorigenesis. However, it is not clear how the abundance and function of PHF8 are regulated. Here, we report that PHF8 physically associates with the deubiquitinase USP7. Specifically, we demonstrated that USP7 promotes deubiquitination and stabilization of PHF8, leading to the upregulation of a group of genes, including cyclin A2, that are critical for cell growth and proliferation. The USP7-encoding gene was also transcriptionally regulated by PHF8, via positive feedback. USP7 was overexpressed in breast carcinomas, and the level of expression positively correlated with expression of PHF8 and cyclin A2 and with the histological grade of breast cancer. We showed that USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 and that the interaction between USP7 and PHF8 is augmented during DNA damage. Moreover, USP7-promoted PHF8 stabilization conferred cellular resistance to genotoxic insults and was required for the recruitment of BLM and KU70, which are both essential for DNA double-strand break repair. Our study mechanistically links USP7 to epigenetic regulation and DNA repair. Moreover, these data support the pursuit of USP7 and PHF8 as potential targets for breast cancer intervention, especially in combination with chemo- or radiotherapies.
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Several well-characterized USP7 substrates, including p53, PHF8, and PLK1, are known to be key regulators of cell cycle progression and cellular proliferation-processes fundamental to HSC maintenance.
“several well-characterized USP7 substrates, including p53 30, PHF8 31, and PLK1 32, are known to be key regulators of cell cycle progression and cellular proliferation—processes fundamental to HSC maintenance.”
From USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization (2026) · cites this paper as [31]
PHF8 interacts with Ku70 and the BLM helicase to facilitate their localization to sites of DSBs.
“In addition to the transcriptional regulation of cyclin A2, PHF8 interacts with Ku70 and the BLM helicase to facilitate their localization to sites of DSBs.”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
Depletion of USP7 greatly compromises the repair of DSBs by either NHEJ or HR.
“The depletion of USP7 from cells has been found to greatly compromise the repair of DSBs by either NHEJ or HR (Wang et al., 2016; An et al., 2017).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
Recruitment of Ku70 or BLM is impaired in cells following PHF8 or USP7 depletion.
“Indeed, the recruitment of either protein is impaired in cells following PHF8 or USP7 depletion (Wang et al., 2016).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
USP7, PHF8 and cyclin A2 were all found to be upregulated in several breast cancers, as well as in colon and rectum cancers, compared to adjacent tissues.
“Indeed, USP7, PHF8 and cyclin A2 were all found to be upregulated in several breast cancers, as well as in colon and rectum cancers, compared to adjacent tissues (Wang et al., 2016).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
A strong correlation has been observed between USP7 and PHF8 in clinical breast cancer samples, increasing with histological grade.
“A strong correlation has also been observed between USP7 and the cell cycle regulatory protein PHF8 (Wang et al., 2016). This correlation was observed in clinical breast cancer samples and increased with histological grade.”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
USP7 deubiquitinates and stabilizes PHF8, allowing PHF8 to upregulate gene targets involved in cell cycle progression, including cyclin A2.
“As we discussed in the Cell Cycle Regulation section, USP7 deubiquitinates and stabilizes PHF8, allowing the latter to upregulate gene targets involved in cell cycle progression, including cyclin A2 (Liu et al., 2010; Wang et al., 2016).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
USP7 is frequently upregulated in breast cancer.
“USP7 has also been suggested as a potential target for sensitization in breast cancer treatment, where USP7 is frequently upregulated and confers resistance to genotoxic insult, by stabilizing PHF8 (Wang et al., 2016).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
USP7 confers resistance to genotoxic insult by stabilizing PHF8.
“USP7 has also been suggested as a potential target for sensitization in breast cancer treatment, where USP7 is frequently upregulated and confers resistance to genotoxic insult, by stabilizing PHF8 (Wang et al., 2016).”
From USP7 Is a Master Regulator of Genome Stability (2020) · cites this paper as Wang et al., 2016
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“XPC is polyubiquitinated in cells in response to UV-induced DNA damage by a complex containing the DDB1-XPE proteins and the Cul4A E3 ubiquitin ligase (Sugasawa et al., 2005; Wang et al., 2005).”
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USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
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USP49 participates in the DNA damage response by forming a positive feedback loop with p53
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PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
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Self-citationEmerging role of ubiquitination/deubiquitination modification of PD-1/PD-L1 in cancer immunotherapy
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Structure-function relationships in KDM7 histone demethylases
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USP7 manipulation by viral proteins
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Self-citationThe deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
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Self-citationLoss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons
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The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis
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PHF8 Plays an Oncogene Function in Hepatocellular Carcinoma Formation
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Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis
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Combination of Inhibitors of USP7 and PLK1 has a Strong Synergism against Paclitaxel Resistance
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Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases
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Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins
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PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability
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Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases
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USP7 substrates identified by proteomics analysis reveal the specificity of USP7Preprint
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The emerging roles of histone demethylases in cancers
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Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3
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USP7 stabilizes EZH2 and enhances cancer malignant progression.
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USP7 deubiquitinates and stabilizes SIRT1.
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Self-citationUSP7 controls NGN3 stability and pancreatic endocrine lineage development
Manea, T., Nelson, J. K., Garrone, C. M., Hansson, K., Evans, I. M., Behrens, A., & Sancho, R. (2023) · Nature Communications · doi:10.1038/s41467-023-38146-9 · Cited by 19 · see citing works
- Authors
- Wang, Q., Ma, S., Song, N., Li, X., Liu, L., Yang, S., Ding, X., Shan, L., Zhou, X., Su, D., Wang, Y., Zhang, Q., Liu, X., Yu, N., Zhang, K., Shang, Y., Yao, Z., & Shi, L.
- Affiliations
- Tianjin Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Corresponding author
- Yao, Zhi
- Shi, Lei
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2016-05-16
- Volume
- 126
- Issue
- 6
- Pages
- 2205-2220
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC4887182
- OpenAlex
- W2381681988
- Cited by
- 206
- References
- 65
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 25 · 2023: 19 · 2022: 23 · 2021: 17 · 2020: 30 · 2019: 24 · 2018: 16 · 2017: 18 · 2016: 5
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tianjin Medical University
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- PHF8, USP7, histone demethylase, protein stabilization, deubiquitination, breast cancer, cyclin A2, DNA double-strand break repair, BLM, Ku70, DNA damage response, epigenetic regulation, positive feedback loop, histone demethylation
- MeSH terms
- Ubiquitin-Specific Peptidase 7, Breast Neoplasms, DNA Damage, DNA Repair, Enzyme Stability, Female, Humans, Transcription Factors, Up-Regulation, RNA, Small Interfering, Ubiquitin Thiolesterase, Epigenesis, Genetic, Protein Interaction Domains and Motifs, Histone Demethylases, Cyclin A2, MCF-7 Cells, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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