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Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development
Open accessAbstract
Elevated protein synthesis is an important feature of many cancer cells and often arises as a consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the mRNA–ribosome recruitment phase of translation initiation. In many cellular and preclinical models of cancer, eIF4F deregulation results in changes in translational efficiency of specific mRNA classes. Importantly, many of these mRNAs code for proteins that potently regulate critical cellular processes, such as cell growth and proliferation, enhanced cell survival and cell migration that ultimately impinge on several hallmarks of cancer, including increased angiogenesis, deregulated growth control, enhanced cellular survival, epithelial-to-mesenchymal transition, invasion, and metastasis. By being positioned as the molecular nexus downstream of key oncogenic signaling pathways (e.g., Ras, PI3K/AKT/TOR, and MYC), eIF4F serves as a direct link between important steps in cancer development and translation initiation. Identification of mRNAs particularly responsive to elevated eIF4F activity that typifies tumorigenesis underscores the critical role of eIF4F in cancer and raises the exciting possibility of developing new-in-class small molecules targeting translation initiation as antineoplastic agents. Cancer Res; 75(2); 250–63. ©2014 AACR.
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“Many direct eIF4A/eIF4F mRNA targets have been identified and often encode proteins that drive proliferation, metastasis, and survival (11, 14, 15).”
From Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer (2023) · cites this paper as [11]
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Metadata
- Authors
- Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N.
- Affiliations
- Institut du cancer Rosalind & Morris Goodman (CA)
- Eli Lilly (United States) (US)
- University of California, San Francisco (US)
- Corresponding author
- Pelletier, Jerry
- Venue
- Cancer Research
- Published
- 2015-01-14
- Volume
- 75
- Issue
- 2
- Pages
- 250-263
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4299928
- OpenAlex
- W2005176113
- Cited by
- 367
- References
- 227
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 30 · 2023: 36 · 2022: 30 · 2021: 39 · 2020: 32 · 2019: 35 · 2018: 40 · 2017: 33 · 2016: 37 · 2015: 19
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@McGill (McGill) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Public Health Service (MOP-106530, MOP-115126)
- National Cancer Institute (R01CA140456, R01CA184624, R01CA154916)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- eIF4F, translation initiation, cancer, translational regulation, oncogenic signaling, Ras, c-Myc, metastasis, epithelial-mesenchymal transition, angiogenesis, cell proliferation
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Neoplasms, Eukaryotic Initiation Factor-4F, Molecular Targeted Therapy
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