The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
tRF/miR-1280 Suppresses Stem Cell–like Cells and Metastasis in Colorectal Cancer
Abstract
Several studies have shown that tRNAs can be enzymatically cleaved to generate distinct classes of tRNA-derived fragments (tRF). Here, we report that tRF/miR-1280, a 17-bp fragment derived from tRNALeu and pre-miRNA, influences Notch signaling pathways that support the function of cancer stem-like cells (CSC) in colorectal cancer progression. tRF/miR-1280 expression was decreased in human specimens of colorectal cancer. Ectopic expression of tRF/miR-1280 reduced cell proliferation and colony formation, whereas its suppression reversed these effects. Mechanistic investigations implicated the Notch ligand JAG2 as a direct target of tRF/miR-1280 binding through which it reduced tumor formation and metastasis. Notably, tRF/miR-1280–mediated inactivation of Notch signaling suppressed CSC phenotypes, including by direct transcriptional repression of the Gata1/3 and miR-200b genes. These results were consistent with findings of decreased levels of miR-200b and elevated levels of JAG2, Gata1, Gata3, Zeb1, and Suz12 in colorectal cancer tissue specimens. Taken together, our results established that tRF/miR-1280 suppresses colorectal cancer growth and metastasis by repressing Notch signaling pathways that support CSC phenotypes. Furthermore, they provide evidence that functionally active miRNA can be derived from tRNA, offering potential biomarker and therapeutic uses. Cancer Res; 77(12); 3194–206. ©2017 AACR.
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1 retracted
Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis
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Cited by
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Shi, Q., Xue, C., Zeng, Y., Yuan, X., Chu, Q., Jiang, S., Wang, J., Zhang, Y., Zhu, D., & Li, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01828-x · Cited by 401
Colorectal liver metastasis: molecular mechanism and interventional therapy
Zhou, H., Liu, Z., Wang, Y., Wen, X., Amador, E. H., Yuan, L., Ran, X., Xiong, L., Ran, Y., Chen, W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00922-2 · Cited by 298
Shen, Y., Yu, X., Zhu, L., Li, T., Yan, Z., & Guo, J. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1693-y · Cited by 256
tRNA-derived fragments and tRNA halves: The new players in cancers
Zhu, L., Ge, J., Li, T., Shen, Y., & Guo, J. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.012 · Cited by 256
Yang, J.-Y., Deng, X.-Y., Li, Y.-S., Ma, X.-C., Feng, J.-X., Yu, B., Chen, Y., Luo, Y.-L., Wang, X., Chen, M.-L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03544-x · Cited by 124
Self-citation
Metadata
- Authors
- Huang, B., Yang, H., Cheng, X., Wang, D., Fu, S., Shen, W., Zhang, Q., Zhang, L., Xue, Z., Li, Y., Da, Y., Yang, Q., Li, Z., Liu, L., Qiao, L., Kong, Y., Yao, Z., Zhao, P., Li, M., & Zhang, R.
- Venue
- Cancer Research
- Published
- 2017-06-14
- Volume
- 77
- Issue
- 12
- Pages
- 3194-3206
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2608110242
- Cited by
- 295
- References
- 47
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, B., Yang, H., Cheng, X., Wang, D., Fu, S., Shen, W., Zhang, Q., Zhang, L., Xue, Z., Li, Y., Da, Y., Yang, Q., Li, Z., Liu, L., Qiao, L., Kong, Y., Yao, Z., Zhao, P., Li, M., & Zhang, R. (2017). tRF/miR-1280 Suppresses Stem Cell–like Cells and Metastasis in Colorectal Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-16-3146
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