Polymer Thin Film-Induced Tumor Spheroids Acquire Cancer Stem Cell-like Properties
Open accessAbstract
: Although cancer stem cells (CSC) are thought to be responsible for tumor recurrence and resistance to chemotherapy, CSC-related research and drug development have been hampered by the limited supply of diverse, patient-derived CSC. Here, we present a functional polymer thin film (PTF) platform that promotes conversion of cancer cells to highly tumorigenic three-dimensional (3D) spheroids without the use of biochemical or genetic manipulations. Culturing various human cancer cells on the specific PTF, poly(2,4,6,8-tetravinyl-2,4,6,8-tetramethyl cyclotetrasiloxane) (pV4D4), gave rise to numerous multicellular tumor spheroids within 24 hours with high efficiency and reproducibility. Cancer cells in the resulting spheroids showed a significant increase in the expression of CSC-associated genes and acquired increased drug resistance compared with two-dimensional monolayer-cultured controls. These spheroids also exhibited enhanced xenograft tumor-forming ability and metastatic capacity in nude mice. By enabling the generation of tumorigenic spheroids from diverse cancer cells, the surface platform described here harbors the potential to contribute to CSC-related basic research and drug development. SIGNIFICANCE: A new cell culture technology enables highly tumorigenic 3D spheroids to be easily generated from various cancer cell sources in the common laboratory.
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ECM can bind soluble factors and modulate integrin-mediated signaling, contributing to cell survival, resistance to apoptosis, and altered therapeutic response.
“the ECM can bind soluble factors and modulate integrin-mediated signaling, contributing to cell survival, resistance to apoptosis, and altered therapeutic response [212].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [212]
The Discussion (page unavailable) says ECM–cancer-cell interactions may promote cancer stem cell characteristics, and the drug-resistance results report that the spheroids resisted doxorubicin. However, the paper does not establish that ECM binding of soluble factors or integrin-mediated signaling promotes survival, prevents apoptosis, or causes the altered drug response. (LLM, conf=0.82)
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- Authors
- Choi, M., Yu, S. J., Choi, Y., Lee, H. R., Lee, E., Lee, E., Lee, Y., Song, J., Son, J. G., Lee, T. G., Kim, J. Y., Kang, S., Baek, J., Lee, D., Im, S. G., & Jon, S.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Korea Research Institute of Standards and Science (KR)
- Corresponding author
- Jon, Sangyong
- ORCID
- Venue
- Cancer Research
- Published
- 2018-12-13
- Volume
- 78
- Issue
- 24
- Pages
- 6890-6902
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2895852838
- Cited by
- 32
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Samsung (SRFC-MA1501-01)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- cancer stem cells, polymer thin films, tumor spheroids, 3D cell culture, drug resistance, metastasis, patient-derived cancer cells
- MeSH terms
- Animals, Female, HeLa Cells, Humans, Materials Testing, Mice, Inbred BALB C, Mice, Nude, Neoplasm Metastasis, Neoplasm Recurrence, Local, Polymers, Neoplastic Stem Cells, Reproducibility of Results, Genome, Spheroids, Cellular, Cell Culture Techniques, Cell Line, Tumor, Mice, Hep G2 Cells, MCF-7 Cells, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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