Cited by 123Circadian rhythm and melatoninCancer Risks and FactorsCancer, Stress, Anesthesia, and Immune Response

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Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort

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Schernhammer, Eva S., Hankinson, Susan E.·2009·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.epi-08-0637PMC PMC3036562

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Abstract

Background: Melatonin seems to play a role in breast cancer etiology, but data addressing the association between melatonin levels and breast cancer risk in postmenopausal women is sparse. Methods: We conducted a nested case-control study in the Nurses' Health Study cohort. First spot morning urine was collected from 18,643 cancer-free women from March 2000 through December 2002. The concentration of the major metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s), was available for 357 postmenopausal women who developed incident breast cancer through May 31, 2006, along with 533 matched control subjects. We used multivariable conditional logistic regression models to investigate associations. All statistical tests were two sided. Results: An increased concentration of urinary aMT6s was statistically significantly associated with a lower risk of breast cancer (odds ratio for the highest versus lowest quartile of morning urinary aMT6s, 0.62; 95% confidence interval, 0.41-0.95; Ptrend = 0.004). There was no apparent modification of risk by hormone receptor status of breast tumors, age, body mass index, or smoking status. Conclusion: Results from this prospective study add substantially to the growing literature that supports an inverse association between melatonin levels and breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2009;18(1):74–9)

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Authors: Schernhammer, E. S., & Hankinson, S. E.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Schernhammer, Eva S.
Hankinson, Susan E.
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2009-01-01
Volume: 18
Issue: 1
Pages: 74-79
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-08-0637
PMC: PMC3036562
OpenAlex: W1979445574
Cited by: 123
References: 48
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 6 · 2014: 17 · 2013: 16 · 2012: 10
FWCI: 3.59
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Emory University
National Institutes of Health (5r01ca049449-18)
National Cancer Institute (CA-49449, CA-87969, U01CA067262, P01CA087969, R01‐CA049449, CA/ES62984, U01CA049449, R01CA067262)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: melatonin, urinary 6-sulfatoxymelatonin, postmenopausal breast cancer, breast cancer risk, hormone receptor status, Nurses' Health Study
MeSH terms: Adult, Breast Neoplasms, Female, Humans, Melatonin, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Biomarkers, Tumor, United States, Logistic Models, Case-Control Studies, Postmenopause

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Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort

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