The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort
Open accessAbstract
Background: Melatonin seems to play a role in breast cancer etiology, but data addressing the association between melatonin levels and breast cancer risk in postmenopausal women is sparse. Methods: We conducted a nested case-control study in the Nurses' Health Study cohort. First spot morning urine was collected from 18,643 cancer-free women from March 2000 through December 2002. The concentration of the major metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s), was available for 357 postmenopausal women who developed incident breast cancer through May 31, 2006, along with 533 matched control subjects. We used multivariable conditional logistic regression models to investigate associations. All statistical tests were two sided. Results: An increased concentration of urinary aMT6s was statistically significantly associated with a lower risk of breast cancer (odds ratio for the highest versus lowest quartile of morning urinary aMT6s, 0.62; 95% confidence interval, 0.41-0.95; Ptrend = 0.004). There was no apparent modification of risk by hormone receptor status of breast tumors, age, body mass index, or smoking status. Conclusion: Results from this prospective study add substantially to the growing literature that supports an inverse association between melatonin levels and breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2009;18(1):74–9)
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“Further, results from prospective cohort studies consistently suggest that women with the lowest concentration of the main melatonin metabolite sulfatoxymelatonin, have the highest risk for breast cancer 96, 97.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [97]
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Models for Longitudinal Data: A Generalized Estimating Equation Approach
Zeger, S. L., Liang, K., & Albert, P. S. (1988) · Biometrics · doi:10.2307/2531734 · Cited by 4,505
Flexible regression models with cubic splines
Durrleman, S., & Simon, R. M. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080504 · Cited by 2,722
Barr, D. B., Wilder, L. C., Caudill, S. P., Gonzalez, A. J., Needham, L. L., & Pirkle, J. L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7337 · Cited by 1,952
Circulating concentrations of insulin-like growth factor I and risk of breast cancer
Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B. J., ROSNER, B. A., Speizer, F. E., & Pollak, M. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10384-1 · Cited by 1,822
Self-citationPercentage Points for a Generalized ESD Many-Outlier Procedure
ROSNER, B. A. (1983) · Technometrics · doi:10.1080/00401706.1983.10487848 · Cited by 1,287
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142
Self-citationCarcinogenicity of shift-work, painting, and fire-fighting
Straif, K., Baan, R., Grosse, Y., Secretan, B., Ghissassi, F. E., Bouvard, V., Altieri, A., Benbrahim-Tallaa, L., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70373-x · Cited by 1,082
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930
A Prospective Study of Postmenopausal Estrogen Therapy and Coronary Heart Disease
Stampfer, M. J., Willett, W. C., Colditz, G. A., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510243131703 · Cited by 855
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson, S. E., Willett, W. C., Manson, J. E., Colditz, G. A., Hunter, D. J., Spiegelman, D. L., Barbieri, R. L., & Speizer, F. E. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.17.1292 · Cited by 687
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Melatonin for the prevention and treatment of cancer
Li, Y., Li, S., Zhou, Y., Meng, X., Zhang, J., Xu, D.-P., & Li, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16379 · Cited by 388
Melatonin secretion and the incidence of type 2 diabetes
McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P. (2013) · JAMA · doi:10.1001/jama.2013.2710 · Cited by 369
Self-citationCircadian Rhythm Connections to Oxidative Stress: Implications for Human Health
Wilking, M. J., Ndiaye, M. A., Mukhtar, H., & Ahmad, N. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4889 · Cited by 333
The inner clock-Blue light sets the human rhythm
Wahl, S., Engelhardt, M., Schaupp, P., Lappe, C., & Ivanov, I. V. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900102 · Cited by 293
Circadian molecular clocks and cancer
Kelleher, F. C., Rao, A. D., & Maguire, A. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.040 · Cited by 283
Metadata
- Authors
- Schernhammer, E. S., & Hankinson, S. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2009-01-01
- Volume
- 18
- Issue
- 1
- Pages
- 74-79
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC3036562
- OpenAlex
- W1979445574
- Cited by
- 123
- References
- 48
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 6 · 2014: 17 · 2013: 16 · 2012: 10
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Emory University
- National Institutes of Health (5r01ca049449-18)
- National Cancer Institute (CA-49449, CA-87969, U01CA067262, P01CA087969, R01‐CA049449, CA/ES62984, U01CA049449, R01CA067262)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- melatonin, urinary 6-sulfatoxymelatonin, postmenopausal breast cancer, breast cancer risk, hormone receptor status, Nurses' Health Study
- MeSH terms
- Adult, Breast Neoplasms, Female, Humans, Melatonin, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Biomarkers, Tumor, United States, Logistic Models, Case-Control Studies, Postmenopause
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