Melatonin and Breast Cancer: A Prospective Study
Abstract
BACKGROUND: Experimental data from animals suggest a protective role for the pineal hormone melatonin in the etiology of breast cancer, but results from the few retrospective case-control studies that examined the association in humans have been inconsistent. To determine whether low levels of endogenous melatonin are associated with an increased risk for developing breast cancer, we conducted a prospective nested case-control study among British women. METHODS: Concentrations of 6-sulfatoxymelatonin, the main metabolite of melatonin in urine and a validated marker of circulating melatonin levels, were measured by radioimmunoassay in 24-hour urine samples collected from women shortly after enrollment in the prospective Guernsey III Study. Levels of 6-sulfatoxymelatonin were compared among 127 patients diagnosed with breast cancer during follow-up and among 353 control subjects, matched for age, recruitment date, menopausal status, and day of menstrual cycle for premenopausal women or number of years postmenopausal for postmenopausal women. Associations were examined by analyses of covariance and conditional logistic regression. All tests of statistical significance were two-sided. RESULTS: No statistically significant differences in urinary 6-sulfatoxymelatonin concentrations were observed between women who developed breast cancer and control subjects among premenopausal or postmenopausal women (P=.8 and P=.9, respectively). When data from premenopausal and postmenopausal women were combined in a multivariable analysis adjusted for potential confounders and grouped into three categories defined by 6-sulfatoxymelatonin tertiles of control subjects, the level of 6-sulfatoxymelatonin excreted was not statistically significantly associated with the risk of breast cancer (odds ratio [OR] for breast cancer = 0.95, 95% confidence interval [CI] = 0.55 to 1.65, comparing the middle category with the lowest category of 6-sulfatoxymelatonin concentration, and OR = 0.99, 95% CI = 0.58 to 1.70, comparing the highest category with the lowest category). CONCLUSION: We found no evidence that the level of melatonin is strongly associated with the risk for breast cancer.
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Results from prospective cohort studies consistently suggest that women with the lowest concentration of the main melatonin metabolite sulfatoxymelatonin have the highest risk for breast cancer.
“Further, results from prospective cohort studies consistently suggest that women with the lowest concentration of the main melatonin metabolite sulfatoxymelatonin, have the highest risk for breast cancer 96, 97.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [96]
Cites
International Journal of Oncology
(2026) · International Journal of Oncology · doi:10.3892/ijo · Cited by 2,332 · see citing works
The Endogenous Hormones and Breast Cancer Collaborative Group (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.8.606 · Cited by 1,793 · see citing works
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930 · see citing works
ELECTRIC POWER USE AND BREAST CANCER: A HYPOTHESIS
Stevens, R. G. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114569 · Cited by 502 · see citing works
The immunoneuroendocrine role of melatonin
Maestroni, G. J. M. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00478.x · Cited by 488 · see citing works
Cantab, M. A. (1976) · PubMed · Cited by 356 · see citing works
Tamarkin, L., Cohen, M., Roselle, D., Reichert, C. M., Lippman, M. E., & Chabner, B. A. (1981) · PubMed · Cited by 296 · see citing works
A population-based case-control study of childhood leukemia in shanghai
Shu, X. O., Gao, Y. T., Tu, J., Zheng, W., Brinton, L. A., Linet, M. S., & Fraumeni, J. F. (1988) · Cancer · doi:10.1002/1097-0142(19880801)62:3 · Cited by 291 · see citing works
Thomas, H., Key, T., Allen, D., Moore, J., Dowsett, M., Fentiman, I., & Wang, D. Y. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.398 · Cited by 289 · see citing works
Self-citationROLE OF PINEAL GLAND IN qTIOLOGY AND TREATMENT OF BREAST CANCER
COHEN, M. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92591-6 · Cited by 251 · see citing works
Decreased Nocturnal Plasma Melatonin Peak in Patients with Estrogen Receptor Positive Breast Cancer
Tamarkin, L., Danforth, D. N., Lichter, A., Demoss, E. V., Cohen, M., Chabner, B. A., & Lippman, M. E. (1982) · Science · doi:10.1126/science.7079745 · Cited by 233 · see citing works
Incidence of cancer among Finnish airline cabin attendants, 1967-92
Pukkala, E., Auvinen, A. P., & Wahlberg, G. (1995) · BMJ · doi:10.1136/bmj.311.7006.649 · Cited by 229 · see citing works
Risk of breast cancer in female flight attendants: a population-based study (Iceland)
Rafnsson, V., Tulinius, H., Jonasson, J. G., & Hrafnkelsson, J. (2001) · Cancer Causes & Control · doi:10.1023/a:1008983416836 · Cited by 228 · see citing works
Radioimmunoassay for 6-Sulphatoxymelatonin in Urine Using an Iodinated Tracer
Aldhous, M., & Arendt, J. (1988) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328802500319 · Cited by 226 · see citing works
Influence of beta-blockers on melatonin release
Stoschitzky, K., Sakotnik, A., Lercher, P., Zweiker, R., Maier, R., Liebmann, P. M., & Lindner, W. F. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050604 · Cited by 215 · see citing works
Light at Night, Shiftwork, and Breast Cancer Risk
Hansen, J. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1513 · Cited by 168 · see citing works
Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.
Molis, T. M., Spriggs, L. L., & Hill, S. M. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.12.7708056 · Cited by 159 · see citing works
Lissoni, P., Barni, S., Meregalli, S., Fossati, V., Cazzaniga, M. E., Esposti, D., & Tancini, G. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.164 · Cited by 150 · see citing works
Prediction of nocturnal plasma melatonin from morning urinary measures
Graham, C. H., Cook, M. R., Kavet, R. I., Sastre, A., & Smith, D. K. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00538.x · Cited by 150 · see citing works
Nonsteroidal anti-inflammatory drugs alter body temperature and suppress melatonin in humans
Murphy, P., Myers, B. L., & Badia, P. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02036-5 · Cited by 137 · see citing works
Urinary melatonin levels in human breast cancer patients
Bartsch, C., Bartsch, H., Jain, A., Laumas, K. R., & Wetterberg, L. (1981) · Journal of Neural Transmission · doi:10.1007/bf01256753 · Cited by 133 · see citing works
Brainard, G. C., Kavet, R. I., & Kheifets, L. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00568.x · Cited by 124 · see citing works
Davis, S. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.591 · Cited by 123 · see citing works
Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancer.
Johnson, T., Anderson, K. E., Lazovich, D., & Folsom, A. R. (2002) · PubMed · Cited by 118 · see citing works
Thomas, H., Key, T., Allen, D., Jw, M., Dowsett, M., Fentiman, I., & Wang, D. Y. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.183 · Cited by 108 · see citing works
Self-citationInverse association between breast cancer incidence and degree of visual impairment in Finland
Verkasalo, P. K., Pukkala, ., Stevens, R. G., Ojamo, M., & Rudanko, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690544 · Cited by 98 · see citing works
Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells
Molis, T. M. (1994) · Molecular Endocrinology · doi:10.1210/me.8.12.1681 · Cited by 96 · see citing works
The role of the neurohormone melatonin as a buffer against macromolecular oxidative damage
Reiter, R. J. (1995) · Neurochemistry International · doi:10.1016/0197-0186(95)80002-3 · Cited by 94 · see citing works
Morning urinary assessment of nocturnal melatonin secretion in older women
Cook, M. R., Graham, C. H., Kavet, R. I., Stevens, R. G., Davis, S., & Kheifets, L. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280106.x · Cited by 92 · see citing works
Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines
Cakir, Y., Plummer, H., Tithof, P. K., & Schuller, H. (2002) · International Journal of Oncology · doi:10.3892/ijo.21.1.153 · Cited by 83 · see citing works
Melatonin modulates growth factor activity in MCF‐7 human breast cancer cells
Cos, S., & Blask, D. E. (1994) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1994.tb00110.x · Cited by 83 · see citing works
Levallois, P. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.601 · Cited by 69 · see citing works
Shiraki, M., Enterline, H. T., Brooks, J. J. S., Cooper, N. S., Hirschl, S., Roth, J. A., Rao, U. N. M., Enzinger, F. M., Amato, D. A., & Borden, E. C. (1989) · Cancer · doi:10.1002/1097-0142(19890715)64:2 · Cited by 68 · see citing works
Melatonin increases oestrogen receptor binding activity of human breast cancer cells
Danforth, D. N., Tamarkin, L., & Lippman, M. E. (1983) · Nature · doi:10.1038/305323a0 · Cited by 68 · see citing works
Plasma melatonin and the hormone-dependency of human breast cancer.
Danforth, D. N., Tamarkin, L., Mulvihill, J. J., Bagley, C., & Lippman, M. E. (1985) · Journal of Clinical Oncology · doi:10.1200/jco.1985.3.7.941 · Cited by 61 · see citing works
Moorman, P. G., Grubber, J. M., Millikan, R. C., & Newman, B. M. (2003) · Epidemiology · doi:10.1097/01.ede.0000050695.99660.d1 · Cited by 56 · see citing works
6‐Sulphatoxymelatonin Production in Breast Cancer Patients
Skene, D. J., Bojkowski, C. J., Currie, J. E., Wright, J., Boulter, P. S., & Arendt, J. (1990) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1990.tb00686.x · Cited by 52 · see citing works
Bartsch, C., Bartsch, H., Karenovics, A., Franz, H. B. G., Peiker, G., & Mecke, D. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00335.x · Cited by 51 · see citing works
Kliukiene, J., Tynes, T., & Andersen, A. (2003) · European Journal of Cancer Prevention · doi:10.1097/00008469-200308000-00010 · Cited by 47 · see citing works
Alcohol Consumption and Urinary Concentration of 6-Sulfatoxymelatonin in Healthy Women
Stevens, R. G., Davis, S., Mirick, D. K., Kheifets, L., & Kaune, W. T. (2000) · Epidemiology · doi:10.1097/00001648-200011000-00008 · Cited by 45 · see citing works
Travis, R. C., Allen, N. E., Peeters, P. H. M., van Noord, P. A. H., & Key, T. J. (2003) · PubMed · Cited by 30 · see citing works
Self-citationLissoni, P., Crispino, S., Barni, S., Sormani, A. L., Brivio, F., Pelizzoni, F., Brenna, A., Bratina, G., & Tancini, G. (2009) · Oncology · doi:10.1159/000226831 · Cited by 29 · see citing works
Murphy, D. L., Garrick, N. A., Tamarkin, L., Taylor, P. L., & Markey, S. P. (1986) · PubMed · Cited by 28 · see citing works
Antiproliferative Effects of Melatonin and CGP 52608
Karasek, M., & Pawlikowski, M. (1999) · Neurosignals · doi:10.1159/000014572 · Cited by 27 · see citing works
Plasma Melatonin in Patients with Breast Cancer
Falkson, G., Falkson, H. C., Steyn, M. E., Rapoport, B. L., & Meyer, B. J. (2009) · Oncology · doi:10.1159/000226857 · Cited by 26 · see citing works
Lissoni, P., Bastone, A., Sala, R. F., Mauri, R., Rovelli, F., Viviani, S., Bajetta, E., Esposti, D., Esposti, G., Bella, L. D., et al. (1987) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(87)90340-3 · Cited by 25 · see citing works
Pineal-Opioid System Interactions in the Control of Immunoinflammatory Responses
Lissoni, P., Barni, S., Tancini, G., Fossati, V., & Frigerio, F. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39659.x · Cited by 14 · see citing works
p53-independentWAF1 induction by ACNU in human glioblastoma cells
Aoki, H., Ohnishi, K., Wang, X., Takahashi, A., Ohnishi, T., Nakamura, M., & Sakaki, T. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199803)21:3 · Cited by 7 · see citing works
Savitz, D. A., & Poole, C. (2001) · Bioelectromagnetics · doi:10.1002/1521-186x(2001)22:5+ · Cited by 7 · see citing works
Prabhala (1991) · doi:10.1002/1097-0142(19910315)67:6
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Fentiman, I. S., Fourquet, A., & Hortobágyi, G. N. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68226-3 · Cited by 773 · see citing works
Self-citationShift work and chronic disease: the epidemiological evidence
Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 640 · see citing works
Self-citationMetabolism and cancer: the circadian clock connection
Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551 · see citing works
Circadian rhythms, sleep, and the menstrual cycle
Baker, F. C., & Driver, H. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.09.011 · Cited by 529 · see citing works
Biological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects
Haus, E. L., & Smolensky, M. H. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9015-4 · Cited by 391 · see citing works
Melatonin for the prevention and treatment of cancer
Li, Y., Li, S., Zhou, Y., Meng, X., Zhang, J., Xu, D.-P., & Li, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16379 · Cited by 388 · see citing works
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works
Circadian Disruption and Breast Cancer
Stevens, R. G. (2005) · Epidemiology · doi:10.1097/01.ede.0000152525.21924.54 · Cited by 295 · see citing works
The inner clock-Blue light sets the human rhythm
Wahl, S., Engelhardt, M., Schaupp, P., Lappe, C., & Ivanov, I. V. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900102 · Cited by 293 · see citing works
Individual Differences in the Amount and Timing of Salivary Melatonin Secretion
Burgess, H. J., & Fogg, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003055 · Cited by 270 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
Kolstad, H. A. (2008) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1194 · Cited by 208 · see citing works
Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., & Cardinali, D. P. (2008) · Integrative Cancer Therapies · doi:10.1177/1534735408322846 · Cited by 208 · see citing works
Hypotheses for mechanisms linking shiftwork and cancer
Fritschi, L., Glass, D. C., Heyworth, J. S., Aronson, K., Girschik, J., Boyle, T., Grundy, A., & Erren, T. C. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.002 · Cited by 201 · see citing works
Urinary Melatonin Levels and Breast Cancer Risk
Schernhammer, E. S., & Hankinson, S. E. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji190 · Cited by 183 · see citing works
Sleep Duration and Breast Cancer: A Prospective Cohort Study
Verkasalo, P. K., Lillberg, K., Stevens, R. G., Hublin, C., Partinen, M., Koskenvuo, M. J., & Kaprio, J. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2138 · Cited by 177 · see citing works
Melatonin as a biomarker of circadian dysregulation
Mirick, D. K., & Davis, S. (2008) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0605 · Cited by 176 · see citing works
Jia, Y., Lu, Y., Wu, K., Lin, Q., Shen, W., Zhu, M., Huang, S., & Chen, J. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.01.005 · Cited by 174 · see citing works
Cohort study of cancer risk among male and female shift workers
Schwartzbaum, J., Ahlbom, A., & Feychting, M. (2007) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.1150 · Cited by 168 · see citing works
Lin, X., Chen, W., Wei, F., Ying, M., Wei, W., & Xie, X. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.02.543 · Cited by 163 · see citing works
Shift work, light at night, and breast cancer on Long Island, New York
O'Leary, E. S., Schoenfeld, E. R., Stevens, R. G., Kabat, G. C., Henderson, K., Grimson, R., Gammon, M. D., & Leske, M. C. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj211 · Cited by 156 · see citing works
Circulating melatonin and the risk of breast and endometrial cancer in women
Viswanathan, A. N., & Schernhammer, E. S. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.11.002 · Cited by 153 · see citing works
Witt‐Enderby, P. A., Radio, N. M., Doctor, J. S., & Davis, V. L. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00369.x · Cited by 150 · see citing works
Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization
Farhood, B., Goradel, N. H., Mortezaee, K., Khanlarkhani, N., Salehi, E., Nashtaei, M. S., Mirtavoos‐Mahyari, H., Motevaseli, E., Shabeeb, D., Musa, A. E., et al. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1934-0 · Cited by 144 · see citing works
Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives
Grant, S. G., Melan, M. A., Latimer, J. J., & Witt‐Enderby, P. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000982 · Cited by 141 · see citing works
Sleep duration, melatonin and breast cancer among Chinese women in Singapore
Wu, A. H., Wang, R., Koh, W., Stanczyk, F. Z., Lee, H.-P., & Yu, M. C. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn100 · Cited by 140 · see citing works
Kayumov, L., Casper, R. F., Hawa, R., Perelman, B., Chung, S. A., Sokalsky, S., & Shapiro, C. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2062 · Cited by 138 · see citing works
Risk of Breast Cancer After Night- and Shift Work: Current Evidence and Ongoing Studies in Denmark
Hansen, J. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9006-5 · Cited by 129 · see citing works
Night Shift Work and Hormone Levels in Women
Davis, S., Mirick, D. K., Chen, C., & Stanczyk, F. Z. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-1128 · Cited by 132 · see citing works
Artificial Lighting in the Industrialized World: Circadian Disruption and Breast Cancer
Stevens, R. G. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9001-x · Cited by 130 · see citing works
Chronobesity: role of the circadian system in the obesity epidemic
Laermans, J., & Depoortere, I. (2015) · Obesity Reviews · doi:10.1111/obr.12351 · Cited by 126 · see citing works
Tong, Z., Luo, W., Wang, Y.-Q., Yang, F., Han, Y., Li, H., Luo, H., Duan, B., Xu, T., Mao‐Ying, Q., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010234 · Cited by 124 · see citing works
Urinary Melatonin Levels and Postmenopausal Breast Cancer Risk in the Nurses' Health Study Cohort
Schernhammer, E. S., & Hankinson, S. E. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0637 · Cited by 123 · see citing works
Increased risk of breast cancer associated with long-term shift work in Canada
Grundy, A. L., Richardson, H., Burstyn, I., Lohrisch, C. A., Sengupta, S., Lai, A. S., Lee, D., Spinelli, J. J., & Aronson, K. J. (2013) · Occupational and Environmental Medicine · doi:10.1136/oemed-2013-101482 · Cited by 120 · see citing works
Breast cancer among shift workers: results of the WOLF longitudinal cohort study
Knutsson, A., Alfredsson, L. S., Karlsson, B., Åkerstedt, T., Fransson, E. I., Westerholm, P. J. M., & Westerlund, H. (2012) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3323 · Cited by 114 · see citing works
Salehi, F., Turner, M. C., Phillips, K. P., Wigle, D. T., Krewski, D. R., & Aronson, K. J. (2008) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400701875923 · Cited by 111 · see citing works
Schernhammer, E. S., Kroenke, C. H., Dowsett, M., Folkerd, E. J., & Hankinson, S. E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00285.x · Cited by 103 · see citing works
Work at night and breast cancer – report on evidence-based options for preventive actions
Bonde, J. P., Hansen, J., Kolstad, H. A., Mikkelsen, S., Olsen, J. H., Blask, D. E., Härmä, M., Kjuus, H., de Koning, H. J., Olsen, J., et al. (2012) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3282 · Cited by 102 · see citing works
Urinary 6-Sulfatoxymelatonin Levels and Risk of Breast Cancer in Postmenopausal Women
Schernhammer, E. S., Berrino, F., Krogh, V., Secreto, G., Micheli, A., Venturelli, E., Sieri, S., Sempos, C. T., Cavalleri, A., Schünemann, H. J., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn171 · Cited by 101 · see citing works
Antioxidants for the Treatment of Breast Cancer: Are We There Yet?
Griñán‐Lisón, C., Blaya-Cánovas, J. L., López-Tejada, A., Ávalos-Moreno, M., Navarro-Ocón, A., Cara, F. E., González-González, A., Lorente, J. A., Marchal, J. A., & Granados-Principal, S. M. (2021) · Antioxidants · doi:10.3390/antiox10020205 · Cited by 98 · see citing works
Night Shift Work and Levels of 6-Sulfatoxymelatonin and Cortisol in Men
Mirick, D. K., Bhatti, P., Chen, C., Nordt, F. J., Stanczyk, F. Z., & Davis, S. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1377 · Cited by 95 · see citing works
Diurnal Urinary 6‐Sulfatoxymelatonin Levels among Healthy Danish Nurses during Work and Leisure Time
Hansen, Å. M., Garde, A. H., & Hansen, J. (2006) · Chronobiology International · doi:10.1080/07420520601100955 · Cited by 81 · see citing works
Leung, M., Tranmer, J. E., Hung, E., Korsiak, J., Day, A. G., & Aronson, K. J. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-1178 · Cited by 77 · see citing works
Endogenous Hormones and Risk of Breast Cancer in Postmenopausal Women
Hankinson, S. E. (2006) · Breast Disease · doi:10.3233/bd-2006-24102 · Cited by 75 · see citing works
Light exposure at night, sleep duration, melatonin, and breast cancer
Yang, W., Deng, Q., Fan, W., Wang, W., & Wang, X. (2014) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000030 · Cited by 74 · see citing works
Rondanelli, M., Faliva, M. A., Perna, S., & Antoniello, N. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0118-6 · Cited by 73 · see citing works
The Influence of Light at Night Exposure on Melatonin Levels among Canadian Rotating Shift Nurses
Grundy, A. L., Tranmer, J. E., Richardson, H., Graham, C. H., & Aronson, K. J. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0427 · Cited by 73 · see citing works
Consumption of vegetables alters morning urinary 6‐sulfatoxymelatonin concentration
Oba, S., Nakamura, K., Sahashi, Y., Hattori, A., & Nagata, C. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00549.x · Cited by 71 · see citing works
Schernhammer, E. S., Berrino, F., Krogh, V., Secreto, G., Micheli, A., Venturelli, E., Grioni, S., Sempos, C. T., Cavalleri, A., Schünemann, H. J., et al. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-1229 · Cited by 69 · see citing works
Sleep disturbances in cancer patients: Underrecognized and undertreated
Dahiya, S., Ahluwalia, M. S., & Walia, H. K. (2013) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.80a.12170 · Cited by 63 · see citing works
Shift work, circadian gene variants and risk of breast cancer
Grundy, A. L., Schuetz, J. M., Lai, A. S., Janoo-Gilani, R., Leach, S. R., Burstyn, I., Richardson, H., Brooks-Wilson, A. R., Spinelli, J. J., & Aronson, K. J. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.04.006 · Cited by 63 · see citing works
Wu, A. H., Stanczyk, F. Z., Wang, R., Koh, W., Yuan, J., & Yu, M. C. (2012) · International Journal of Cancer · doi:10.1002/ijc.27653 · Cited by 56 · see citing works
Melatonin, environmental light, and breast cancer
Srinivasan, V. J., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., Esquifino, A. I., Cardinali, D. P., & Maestroni, G. J. M. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9617-5 · Cited by 53 · see citing works
Electromagnetic Fields and Female Breast Cancer
Feychting, M., & Forssén, U. M. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9008-3 · Cited by 53 · see citing works
Gürsoy, A. Y., Kiseli, M., & Çağlar, G. S. (2015) · Climacteric · doi:10.3109/13697137.2015.1052393 · Cited by 50 · see citing works
Pepłońska, B., Bukowska, A., Gromadzińska, J., Sobala, W., Reszka, E., Lie, J.-A. S., Kjuus, H., & Wąsowicz, W. (2012) · Occupational and Environmental Medicine · doi:10.1136/oemed-2011-100273 · Cited by 50 · see citing works
Western Diseases: An Evolutionary Perspective
Pollard, T. M. (2008) · Durham Research Online (Durham University) · Cited by 48 · see citing works
The impact of chronotype on melatonin levels among shift workers
Bhatti, P., Mirick, D. K., & Davis, S. (2014) · Occupational and Environmental Medicine · doi:10.1136/oemed-2013-101730 · Cited by 47 · see citing works
Gómez‐Acebo, I., Dierssen‐Sotos, T., Papantoniou, K., García‐Unzueta, M. T., Santos-Benito, M. F., & Llorca, J. (2014) · Chronobiology International · doi:10.3109/07420528.2014.958494 · Cited by 47 · see citing works
Basler, M., Jetter, A., Fink, D. A., Seifert, B., Kullak-Ublick, G. A., & Trojan, A. (2014) · Breast Care · doi:10.1159/000363426 · Cited by 45 · see citing works
Melatonin and tryptophan circadian profiles in patients with advanced non-small cell lung cancer
Hu, S., Shen, G., Yin, S., Xu, W., & Hu, B. (2009) · Advances in Therapy · doi:10.1007/s12325-009-0068-8 · Cited by 43 · see citing works
Vitale, J. A., Lombardi, G., Weydahl, A., & Banfi, G. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1475395 · Cited by 42 · see citing works
Sleep Disruption and Cancer: Chicken or the Egg?
Berisha, A., Shutkind, K., & Borniger, J. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856235 · Cited by 42 · see citing works
Light and Exercise and Melatonin Production in Women
Knight, J. A., Thompson, S., Raboud, J., & Hoffman, B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi327 · Cited by 41 · see citing works
Individual Variations in Serum Melatonin Levels through Time: Implications for Epidemiologic Studies
Nogueira, L., Sampson, J. N., Chu, L. W., Yu, K. F., Andriole, G. L., Church, T. R., Stanczyk, F. Z., Koshiol, J. E., & Hsing, A. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083208 · Cited by 37 · see citing works
Musijowski, J., Poboży, E., & Trojanowicz, M. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.11.063 · Cited by 33 · see citing works
Nutritional and lifestyle correlates of the cancer-protective hormone melatonin
Dopfel, R. P., Schulmeister, K., & Schernhammer, E. S. (2007) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2007.02.001 · Cited by 32 · see citing works
Racial Differences in the Association Between Night Shift Work and Melatonin Levels Among Women
Bhatti, P., Mirick, D. K., & Davis, S. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws278 · Cited by 32 · see citing works
Urinary Melatonin Concentration and the Risk of Breast Cancer in Nurses' Health Study II
Brown, S. B. F., Hankinson, S. E., Eliassen, A. H., Reeves, K. W., Qian, J., Arcaro, K. F., Wegrzyn, L. R., Willett, W. C., & Schernhammer, E. S. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwu261 · Cited by 31 · see citing works
Davis, S., Mirick, D. K., CHEN, C., & Stanczyk, F. Z. (2006) · Annals of Epidemiology · doi:10.1016/j.annepidem.2005.11.005 · Cited by 31 · see citing works
Shift Work, Light at Night, and the Risk of Breast Cancer
Reed, V. A. (2010) · AAOHN Journal · doi:10.3928/08910162-20101216-01 · Cited by 28 · see citing works
Franz Halberg, A., Cornélissen, G., Ulmer, W., Blank, M., Hrushesky, W. J. M., Wood, P. A., Singh, R. K., & Wang, Z. (2006) · PubMed · Cited by 27 · see citing works
Circadian Rhythms and Shift Working Women
Shechter, A., James, F. O., & Boivin, D. B. (2008) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.10.008 · Cited by 27 · see citing works
Urinary 6-sulfatoxymelatonin level and breast cancer risk: systematic review and meta-analysis
Xu, J., Huang, L., & Sun, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-05752-9 · Cited by 27 · see citing works
Recent technical strategies to identify diagnostic biomarkers for ovarian cancer
Ye, B., Gagnon, A., & Mok, S. C. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.1.121 · Cited by 27 · see citing works
Re: Melatonin and Breast Cancer: A Prospective Study
Hrushesky, W. J. M., & Blask, D. E. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh175 · Cited by 27 · see citing works
Rotating Night Shift Work and Mammographic Density
Pepłońska, B., Bukowska, A., Sobala, W., Reszka, E., Gromadzińska, J., Wąsowicz, W., Lie, J.-A. S., Kjuus, H., & Ursin, G. (2012) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0005 · Cited by 26 · see citing works
First-Morning Urinary Melatonin and Breast Cancer Risk in the Guernsey Study
Wang, X.-S., Tipper, S., Appleby, P. N., Allen, N. E., Key, T. J., & Travis, R. C. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwt302 · Cited by 26 · see citing works
Self-citationElectromagnetic Field Exposure and Male Breast Cancer Risk: A Meta-analysis of 18 Studies
Sun, J., Li, X., Gao, H.-Y., Yin, J., Qin, Q., Nie, S., & Wei, S. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.1.523 · Cited by 26 · see citing works
Chronotype and risk of post-menopausal endometrial cancer in the California Teachers Study
Behren, J. V., Hurley, S. E., Goldberg, D. E., DeHart, J. C., Wang, S., & Reynolds, P. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1912073 · Cited by 23 · see citing works
Serum Melatonin in Women with Polycystic Ovary Syndrome
Terzieva, D. D., Orbetzova, M. M., Mitkov, M., & Mateva, N. G. (2013) · Folia Medica · doi:10.2478/folmed-2013-0012 · Cited by 25 · see citing works
Pollard, T. M. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511841118 · Cited by 25 · see citing works
The Role of Melatonin in Cancer Development
Liu, S., Madu, C. O., & Lu, Y. E. (2018) · Oncomedicine · doi:10.7150/oncm.25566 · Cited by 23 · see citing works
Schernhammer, E. S., Feskanich, D., Niu, C., Dopfel, R. P., Holmes, M. D., & Hankinson, S. E. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27826 · Cited by 24 · see citing works
Hurley, S. E., Nelson, D. O., Garcia, E., Gunier, R. B., Hertz, A., & Reynolds, P. (2013) · International Journal of Health Geographics · doi:10.1186/1476-072x-12-39 · Cited by 24 · see citing works
Sturgeon, S. R., Doherty, A., Reeves, K. W., Bigelow, C., Stanczyk, F. Z., Ockene, J. K., Liu, S., Manson, J. E., & Neuhouser, M. L. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-1028 · Cited by 24 · see citing works
Devore, E. E., Warner, E. T., Eliassen, A. H., Brown, S. B., Beck, A. H., Hankinson, S. E., & Schernhammer, E. S. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0630 · Cited by 21 · see citing works
Dickerman, B. A., & Liu, J. (2012) · Workplace Health & Safety · doi:10.1177/216507991206000607 · Cited by 19 · see citing works
Labrèche, F., Goldberg, M. S., Hashim, D., & Weiderpass, E. (2020) · Springer eBooks · doi:10.1007/978-3-030-30766-0_24 · Cited by 19 · see citing works
Dickerman, B. A., & Liu, J. (2012) · Workplace Health & Safety · doi:10.3928/21650799-20120529-06 · Cited by 15 · see citing works
Sleep Duration and Breast Cancer Phenotype
Khawaja, A. I., Rao, S. K., Li, L., & Thompson, C. L. (2013) · Journal of Cancer Epidemiology · doi:10.1155/2013/467927 · Cited by 15 · see citing works
Masue, T., Wada, K., Hayashi, M., Takeda, N., Yasuda, K., Deguchi, T., & Nagata, C. (2011) · Metabolism · doi:10.1016/j.metabol.2011.05.021 · Cited by 14 · see citing works
Melatonin-Induced Oncostasis, Mechanisms and Clinical Relevance
Cardinali, D. P., & Escames, G. (2016) · Journal of Integrative Oncology · doi:10.4172/2329-6771.s1-006 · Cited by 13 · see citing works
Moderate Alcohol Consumption and 24-Hour Urinary Levels of Melatonin in Postmenopausal Women
Hartman, T. J., Mahabir, S., Baer, D. J., Stevens, R. G., Albert, P. S., Dorgan, J. F., Kesner, J. S., Meadows, J. W., Shields, R., & Taylor, P. R. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1904 · Cited by 12 · see citing works
Wong, A. T. Y., Fensom, G. K., Key, T. J., Onland‐Moret, N. C., Tong, T. Y. N., & Travis, R. C. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0822 · Cited by 12 · see citing works
Self-citationWada, K., Nakamura, K., Tamai, Y., Tsuji, M., Masue, T., Watanabe, K., Ando, K., & Nagata, C. (2012) · Annals of Epidemiology · doi:10.1016/j.annepidem.2012.11.003 · Cited by 12 · see citing works
Risk Factors for Male Breast Cancer
Fentiman, I. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-89929-4_2 · Cited by 11 · see citing works
Self-citationLee, K. K., Ahn, C. H., & Hong, C. I. (2013) · Biomicrofluidics · doi:10.1063/1.4819478 · Cited by 9 · see citing works
Megavath, S., Nagarakanti, S., & Chava, V. K. (2023) · Journal of Indian Society of Periodontology · doi:10.4103/jisp.jisp_392_21 · Cited by 8 · see citing works
Sommeil et cancer du sein : existe-t-il un lien ?
Malina, C., Frigo, S., & Mathelin, C. (2013) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2012.12.008 · Cited by 7 · see citing works
- Authors
- Travis, R. C., Allen, D. S., Fentiman, I. S., & Key, T. J.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Travis, R. C.
- ORCID
- Travis, R. C.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-16
- Volume
- 96
- Issue
- 6
- Pages
- 475-482
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2160684230
- Cited by
- 149
- References
- 50
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 15 · 2012: 12
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- melatonin, breast cancer risk, 6-sulfatoxymelatonin, urinary melatonin metabolites, pineal hormone, premenopausal women, postmenopausal women
- MeSH terms
- Adult, Aged, Breast Neoplasms, Female, United Kingdom, Humans, Melatonin, Menopause, Middle Aged, Prospective Studies, Risk Factors, Multivariate Analysis, Odds Ratio, Case-Control Studies, Matched-Pair Analysis, Risk Assessment
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