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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue
Abstract
Overweight and obesity are health problems of epidemic proportions, increasing the risk not only of cardiovascular disease and type 2 diabetes mellitus but also of various types of cancer. Obesity is strongly associated with changes in the physiological function of adipose tissue, leading to insulin resistance, chronic inflammation, and altered secretion of adipokines. Several of these factors, such as insulin resistance, increased levels of leptin, plasminogen activator inhibitor-1, and endogenous sex steroids, decreased levels of adiponectin, and chronic inflammation, are involved in carcinogenesis and cancer progression. This article reviews these mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor. Although understanding of the link between obesity and cancer might provide therapeutic targets, preventing overweight and obesity still remains number one priority.
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“As recently reviewed, adipose tissue is an active endocrine organ producing free fatty acids, interleukin-6 (IL-6), monocyte chemoattractant protein, plasminogen activator inhibitor-1 (PAI-1), adiponectin, leptin, and tumor necrosis factor-α (69).”
From Diabetes and Cancer (2010) · cites this paper as [69]
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Metadata
- Authors
- van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J.
- Affiliations
- Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands
- University Medical Center Utrecht (NL)
- Corresponding author
- Visseren, Frank L.J.
- ORCID
- Visseren, Frank L.J.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2009-10-01
- Volume
- 18
- Issue
- 10
- Pages
- 2569-2578
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2152913697
- Cited by
- 715
- References
- 159
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 24 · 2023: 35 · 2022: 37 · 2021: 49 · 2020: 36 · 2019: 53 · 2018: 52 · 2017: 58 · 2016: 40 · 2015: 65 · 2014: 55 · 2013: 70 · 2012: 49
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, cancer, adipose tissue dysfunction, insulin resistance, chronic inflammation, adipokines, leptin, plasminogen activator inhibitor-1, sex steroids, adiponectin, carcinogenesis, tumor progression, overweight prevention
- MeSH terms
- Adipose Tissue, Humans, Neoplasms, Obesity
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