Cited by 717Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsAdipose Tissue and Metabolism

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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

van Kruijsdijk, Rob C.M., van der Wall, Elsken, Visseren, Frank L.J.·2009·Cancer Epidemiology, Biomarkers & Prevention

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Abstract

Overweight and obesity are health problems of epidemic proportions, increasing the risk not only of cardiovascular disease and type 2 diabetes mellitus but also of various types of cancer. Obesity is strongly associated with changes in the physiological function of adipose tissue, leading to insulin resistance, chronic inflammation, and altered secretion of adipokines. Several of these factors, such as insulin resistance, increased levels of leptin, plasminogen activator inhibitor-1, and endogenous sex steroids, decreased levels of adiponectin, and chronic inflammation, are involved in carcinogenesis and cancer progression. This article reviews these mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor. Although understanding of the link between obesity and cancer might provide therapeutic targets, preventing overweight and obesity still remains number one priority.

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Authors: van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J.
Affiliations: Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands
University Medical Center Utrecht (NL)
Corresponding author: Visseren, Frank L.J.
ORCID: Visseren, Frank L.J.
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2009-10-01
Volume: 18
Issue: 10
Pages: 2569-2578
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-09-0372
OpenAlex: W2152913697
Cited by: 715
References: 159
Citations by year: 2026: 11 · 2025: 18 · 2024: 24 · 2023: 35 · 2022: 37 · 2021: 49 · 2020: 36 · 2019: 53 · 2018: 52 · 2017: 58 · 2016: 40 · 2015: 65 · 2014: 55 · 2013: 70 · 2012: 49
FWCI: 4.57
Type: journal article
Language: en
Open access: closed
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: obesity, cancer, adipose tissue dysfunction, insulin resistance, chronic inflammation, adipokines, leptin, plasminogen activator inhibitor-1, sex steroids, adiponectin, carcinogenesis, tumor progression, overweight prevention
MeSH terms: Adipose Tissue, Humans, Neoplasms, Obesity

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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

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