The DOI matches its Crossref record; 155 of the 159 references it cites were found in a registry or an index.
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue
Abstract
Overweight and obesity are health problems of epidemic proportions, increasing the risk not only of cardiovascular disease and type 2 diabetes mellitus but also of various types of cancer. Obesity is strongly associated with changes in the physiological function of adipose tissue, leading to insulin resistance, chronic inflammation, and altered secretion of adipokines. Several of these factors, such as insulin resistance, increased levels of leptin, plasminogen activator inhibitor-1, and endogenous sex steroids, decreased levels of adiponectin, and chronic inflammation, are involved in carcinogenesis and cancer progression. This article reviews these mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor. Although understanding of the link between obesity and cancer might provide therapeutic targets, preventing overweight and obesity still remains number one priority.
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“As recently reviewed, adipose tissue is an active endocrine organ producing free fatty acids, interleukin-6 (IL-6), monocyte chemoattractant protein, plasminogen activator inhibitor-1 (PAI-1), adiponectin, leptin, and tumor necrosis factor-α (69).”
From Diabetes and Cancer (2010) · cites this paper as [69]
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1 retracted
Cascio, S., Bartella, V., Auriemma, A., Johannes, G. J., Russo, A. D., Giordano, A., & Surmacz, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210660 · Cited by 79
RetractedGrundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866
Research works printed but not linked: 1
- World Health Organisation, 2000, Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation on Obesity
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Rôle du stroma dans la progression de l'adénocarcinome pancréatique
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Helou, M. E. (2017) · theses.fr (ABES) · doi:10.70675/0c7d676dz64a3z4641zb8cbzd99a75ef2126 · Cited by 1
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Mroueh, F. M. (2017) · theses.fr (ABES) · doi:10.70675/65c64643z9facz43ddz8889z715719c5dcb8
T cell dysregulation and remodeling in pediatric obesity and weight lossPreprint
Hay, C., Sayed, S. U., Espinoza, D. A., Knight, M., Abrams, E. D., Campos, J. S., Nagy, M. Z., Nelson, M. A., Sheetz, S. A., Gunnala, P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.19.722395
吕, 晓. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1662363
The Association Between Cancer Incidence and Heart Failure: A Systematic Review and Meta-Analysis
Alharazy, S. M., Karikalan, B., Azzani, M., Kabir, M. S., Anbazhagan, D., Gopalakrishna, P. K., Thangarajan, R., Shediwah, A., Alsaidi, N. A., Ali-Saeed, R., et al. (2026) · Diagnostics · doi:10.3390/diagnostics16132016
Cengiz, M., Ege, H. V., Zaim, O. C., Temiz, B. E., Akgör, U., Gültekin, M., Özgül, N., Tuncer, Z. S., Akkapulu, N., Kılıçaslan, B., et al. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08848-2
Exercise as anticancer medicine? Evidence, mechanisms and implementation in oncology
Schmidinger, M., Huebner-Resch, I., & Shariat, S. F. (2026) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2026.103222
Obesity-Related Effects on Pancreatic Disease
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Metadata
- Authors
- van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J.
- Affiliations
- Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands
- University Medical Center Utrecht (NL)
- Corresponding author
- Visseren, Frank L.J.
- ORCID
- Visseren, Frank L.J.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2009-10-01
- Volume
- 18
- Issue
- 10
- Pages
- 2569-2578
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2152913697
- Cited by
- 715
- References
- 159
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 24 · 2023: 35 · 2022: 37 · 2021: 49 · 2020: 36 · 2019: 53 · 2018: 52 · 2017: 58 · 2016: 40 · 2015: 65 · 2014: 55 · 2013: 70 · 2012: 49
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- obesity, cancer, adipose tissue dysfunction, insulin resistance, chronic inflammation, adipokines, leptin, plasminogen activator inhibitor-1, sex steroids, adiponectin, carcinogenesis, tumor progression, overweight prevention
- MeSH terms
- Adipose Tissue, Humans, Neoplasms, Obesity
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