The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
Abstract
Metabolic and therapeutic stresses activate several signal transduction pathways that regulate cell death and cell survival in cancer cells. Although decades of research unraveled the pathways that regulate apoptosis and allowed the development of novel diagnostic and therapeutic modalities in cancer treatment, only recently has the regulation and significance of tumor cell autophagy and necrosis become the focus of investigations. Necrosis is an irreversible inflammatory form of cell death. In contrast, autophagy is a reversible process that can contribute both to tumor cell death and survival. This review describes recent advances in understanding the regulation of autophagy and necrosis and their implications for cancer therapy. Currently available methods to measure autophagy and necrosis are highlighted. The effect of tumor cell autophagy and necrosis on host immunity is explored. Finally, therapeutic approaches that target autophagy and necrosis in cancer are described.
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Cites
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Metadata
- Authors
- Amaravadi, R. K., & Thompson, C. B.
- Venue
- Clinical Cancer Research
- Published
- 2007-12-15
- Volume
- 13
- Issue
- 24
- Pages
- 7271-7279
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2166895841
- Cited by
- 465
- References
- 17
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amaravadi, R. K., & Thompson, C. B. (2007). The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-07-1595
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