The Role of Ferroptosis in Cancer Development and Treatment Response

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Ferroptosis: process and function

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Ferroptosis as a p53-mediated activity during tumour suppression

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Autophagy promotes ferroptosis by degradation of ferritin

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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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Apoptosis. Its significance in cancer and cancer Therapy

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

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Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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Ferroptosis is an autophagic cell death process

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

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The role of autophagy in cancer development and response to therapy

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RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

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Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

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Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

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The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

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HSPB1 as a novel regulator of ferroptotic cancer cell death

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Regulated necrosis: disease relevance and therapeutic opportunities

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Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities

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Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

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System x c ‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

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Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

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The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment

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The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

Yan, Y., Xie, Y., Cao, L., Yang, L., Yang, M., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1054549 · Cited by 467 · see citing works

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

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Redox imbalance in cystine/glutamate transporter-deficient mice

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Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

Ooko, E., Saeed, M. E. M., Kadioglu, O., Sarvi, S., Colak, M., Elmasaoudi, K., Janah, R., Greten, H. J., & Efferth, T. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.08.002 · Cited by 387 · see citing works

Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer

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The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

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Cystine-Glutamate Transporter SLC7A11 in Cancer Chemosensitivity and Chemoresistance

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Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

Lin, R., Zhang, Z., Chen, L., Zhou, Y., Zou, P., Feng, C., Wang, L., & Liang, G. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.07.033 · Cited by 296 · see citing works

HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cells

Liu, L., Yang, M., Kang, R., Wang, Z., Zhao, Y., Yu, Y. H., Xie, M., Yin, X.-C., Livesey, K. M., Lotze, M. T., et al. (2010) · Leukemia · doi:10.1038/leu.2010.225 · Cited by 249 · see citing works

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

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The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

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Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

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Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

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Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib

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The 5‐lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages

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Caspase-Independent Cell Death Is Involved in the Negative Effect of EGF Receptor Inhibitors on Cisplatin in Non–Small Cell Lung Cancer Cells

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Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

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Heat shock protein 27 downregulates the transferrin receptor 1-mediated iron uptake

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New biological perspectives for the improvement of the efficacy of sorafenib in hepatocellular carcinoma

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Unraveling the Role of Autophagy in Cancer

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Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

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Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

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Microcytic hypochromic anemia associated with renal cell carcinoma

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Ferroptosis, a new form of cell death: opportunities and challenges in cancer

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Recent Progress in Ferroptosis Inducers for Cancer Therapy

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Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

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The development of the concept of ferroptosis

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Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

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Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

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Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death

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Oxidative cell death in cancer: mechanisms and therapeutic opportunities

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A Dual Role of Heme Oxygenase-1 in Cancer Cells

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Metabolism of Amino Acids in Cancer

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Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

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Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

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Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

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Iron Metabolism in Cancer

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Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

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Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

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Iron as a central player and promising target in cancer progression

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Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

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DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

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Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

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Systematic Analysis of the Aberrances and Functional Implications of Ferroptosis in Cancer

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The mechanism of ferroptosis and its related diseases

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Ferroptosis-driven nanotherapeutics for cancer treatment

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Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

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Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance

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Progress in understanding the role of lncRNA in programmed cell death

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Nanomaterial-induced ferroptosis for cancer specific therapy

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Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells

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miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

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A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells

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Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis

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Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential

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Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer

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Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma

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Ferroptosis in Cancer Progression

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Ferroptosis: A New Road towards Cancer Management

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