Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer
Open accessAbstract
Purpose: Biomarkers of radiation-induced behavioral symptoms, such as fatigue, have not been identified. Studies linking inflammatory processes to fatigue in cancer survivors led us to test the hypothesis that activation of the proinflammatory cytokine network is associated with fatigue symptoms during radiation therapy for breast and prostate cancer. Experimental Design: Individuals with early-stage breast (n = 28) and prostate cancer (n= 20) completed questionnaires and provided blood samples for determination of serum levels of interleukin 1β (IL-1β) and IL-6 at assessments conducted before, during, and after a course of radiation therapy. Serum markers of proinflammatory cytokine activity, including IL-1 receptor antagonist and C-reactive protein, were examined in a subset of participants. Random coefficient models were used to evaluate the association between changes in cytokine levels and fatigue. Results: As expected, there was a significant increase in fatigue during radiation treatment. Changes in serum levels of inflammatory markers C-reactive protein and IL-1 receptor antagonist were positively associated with increases in fatigue symptoms (Ps < 0.05), although serum levels of IL-1β and IL-6 were not associated with fatigue. These effects remained significant (Ps < 0.05) in analyses controlling for potential biobehavioral confounding factors, including age, body mass index, hormone therapy, depression, and sleep disturbance. Conclusions: Results suggest that activation of the proinflammatory cytokine network and associated increases in downstream biomarkers of proinflammatory cytokine activity are associated with fatigue during radiation therapy for breast and prostate cancer.(Clin Cancer Res 2009;15(17):5534–40)
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Even after controlling for concurrent depressed mood, inflammation remains associated with both attentional bias and fatigue.
“Indeed, the association between inflammation and both attentional bias and fatigue remain when accounting for concurrent depressed mood (Bower et al., 2009; Boyle et al., 2017).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Bower et al., 2009
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- Authors
- Bower, J. E., Ganz, P. A., Tao, M. L., Hu, W., Belin, T. R., Sepah, S., Cole, S., & Aziz, N.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Bower, Julienne E.
- Venue
- Clinical Cancer Research
- Published
- 2009-08-31
- Volume
- 15
- Issue
- 17
- Pages
- 5534-5540
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC2884979
- OpenAlex
- W2068185418
- Cited by
- 315
- References
- 44
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 21 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 20 · 2018: 16 · 2017: 18 · 2016: 16 · 2015: 17 · 2014: 21 · 2013: 21 · 2012: 35
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- California Breast Cancer Research Program
- National Institutes of Health
- National Cancer Institute (K07CA090407, K07-CA90407, R01CA116778)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- radiation-induced fatigue, inflammatory markers, inflammatory cytokines, breast cancer, prostate cancer, IL-1β, interleukin-6, C-reactive protein, interleukin-1 receptor antagonist, radiotherapy complications, cancer survivors
- MeSH terms
- Adult, Aged, Breast Neoplasms, C-Reactive Protein, Fatigue, Female, Humans, Inflammation, Male, Middle Aged, Prostatic Neoplasms, Biomarkers, Interleukin-6, Interleukin-1beta
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