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Cited by 250

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

Zhao, Mei, Sano, Daisuke, Pickering, Curtis R., Jasser, Samar A., Henderson, Ying C., Clayman, Gary L., Sturgis, Erich M., Ow, Thomas J., Lotan, Reuben, Carey, Thomas E., Sacks, Peter G., Grandis, Jennifer R., Sidransky, David, Heldin, Nils Erik, Myers, Jeffrey N.·2011·Clinical Cancer Research
DOI 10.1158/1078-0432.ccr-11-0690PMC PMC3229662

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Abstract

Purpose: Human cell lines are useful for studying cancer biology and preclinically modeling cancer therapy, but can be misidentified and cross-contamination is unfortunately common. The purpose of this study was to develop a panel of validated head and neck cell lines representing the spectrum of tissue sites and histologies that could be used for studying the molecular, genetic, and phenotypic diversity of head and neck cancer. Methods: A panel of 122 clinically and phenotypically diverse head and neck cell lines from head and neck squamous cell carcinoma, thyroid cancer, cutaneous squamous cell carcinoma, adenoid cystic carcinoma, oral leukoplakia, immortalized primary keratinocytes, and normal epithelium was assembled from the collections of several individuals and institutions. Authenticity was verified by carrying out short tandem repeat analysis. Human papillomavirus (HPV) status and cell morphology were also determined. Results: Eighty-five of the 122 cell lines had unique genetic profiles. HPV-16 DNA was detected in 2 cell lines. These 85 cell lines included cell lines from the major head and neck primary tumor sites, and close examination shows a wide range of in vitro phenotypes. Conclusions: This panel of 85 genomically validated head and neck cell lines represents a valuable resource for the head and neck cancer research community that can help advance understanding of the disease by providing a standard reference for cell lines that can be used for biological as well as preclinical studies. Clin Cancer Res; 17(23); 7248–64. ©2011 AACR.

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Metadata

Authors
Zhao, M., Sano, D., Pickering, C. R., Jasser, S. A., Henderson, Y. C., Clayman, G. L., Sturgis, E. M., Ow, T. J., Lotan, R., Carey, T. E., Sacks, P. G., Grandis, J. R., Sidransky, D., Heldin, N. E., & Myers, J. N.
Affiliations
Authors' Affiliations: Departments of 1Head and Neck Surgery and 2Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; 3Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, Michigan; 4Department of Basic Science and Craniofacial Biology, College of Dentistry, New York University, New York, New York; 5Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; 6Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland; and 7Department of Pathology, University of Uppsala, Uppsala, Sweden
Venue
Clinical Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2011-11-30
Volume
17
Issue
23
Pages
7248-7264
ISSN
  • 1078-0432
  • 1557-3265
DOI
10.1158/1078-0432.ccr-11-0690
PMC
PMC3229662
Cited by
250
References
10
Language
en

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CoChat. (2026). Citation check: Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites. https://app.cochat.ai/papers/10.1158/1078-0432.ccr-11-0690
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Zhao, M., Sano, D., Pickering, C. R., Jasser, S. A., Henderson, Y. C., Clayman, G. L., Sturgis, E. M., Ow, T. J., Lotan, R., Carey, T. E., Sacks, P. G., Grandis, J. R., Sidransky, D., Heldin, N. E., & Myers, J. N. (2011). Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-11-0690