Cited by 287Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisLipid metabolism and disorders

The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

Open access

Kuemmerle, Nancy B., Rysman, Evelien, Lombardo, Portia S., Flanagan, Alison J., Lipe, Brea C., Wells, Wendy A., Pettus, Jason R., Froehlich, Heather M., Memoli, Vincent A., Morganelli, Peter M., Swinnen, Johannes V., Timmerman, Luika A., Chaychi, Leila, Fricano, Catherine J., Eisenberg, Burton L., Coleman, William B., Kinlaw, William B.·2011·Molecular Cancer Therapeutics

DOI 10.1158/1535-7163.mct-10-0802PMC PMC3074101

Published version of a preprint

Open this paper in CoChat — free account Open PDF

Abstract

Many types of cancer cells require a supply of fatty acids (FA) for growth and survival, and interrupting de novo FA synthesis in model systems causes potent anticancer effects. We hypothesized that, in addition to synthesis, cancer cells may obtain preformed, diet-derived FA by uptake from the bloodstream. This would require hydrolytic release of FA from triglyceride in circulating lipoprotein particles by the secreted enzyme lipoprotein lipase (LPL), and the expression of CD36, the channel for cellular FA uptake. We find that selected breast cancer and sarcoma cells express and secrete active LPL, and all express CD36. We further show that LPL, in the presence of triglyceride-rich lipoproteins, accelerates the growth of these cells. Providing LPL to prostate cancer cells, which express low levels of the enzyme, did not augment growth, but did prevent the cytotoxic effect of FA synthesis inhibition. Moreover, LPL knockdown inhibited HeLa cell growth. In contrast to the cell lines, immunohistochemical analysis confirmed the presence of LPL and CD36 in the majority of breast, liposarcoma, and prostate tumor tissues examined (n = 181). These findings suggest that, in addition to de novo lipogenesis, cancer cells can use LPL and CD36 to acquire FA from the circulation by lipolysis, and this can fuel their growth. Interfering with dietary fat intake, lipolysis, and/or FA uptake will be necessary to target the requirement of cancer cells for FA.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/1535-7163.mct-10-0802

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Sørlie, T., Perou, C. M., Tibshirani, R. J., Aas, T., Geisler, S. B., Johnsen, H., Hastie, T. J., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191367098 · Cited by 11,506
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,224
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
Goldstein, J. L., Basu, S. K., & Brown, M. S. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)98152-1 · Cited by 1,629
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S.-W., & Cravatt, B. F. (2010) · Cell · doi:10.1016/j.cell.2009.11.027 · Cited by 1,002

Show all 46 references

Research works printed but not linked: 2

Weiss, 1986, Fatty-acid biosynthesis in man, a pathway of minor importance, J Biol Chem, 367, 905
Parlo, 1984, Enhanced rate of citrate export from cholesterol-rich hepatoma mitochondria, J Biol Chem, 259.

Sorted by citations

The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Bensaad, K., Favaro, E., Lewis, C. A., Peck, B., Lord, S., Collins, J. M., Pinnick, K. E., Wigfield, S., Buffa, F. M., Li, J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.056 · Cited by 667
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation
Schiliro, C., & Firestein, B. L. (2021) · Cells · doi:10.3390/cells10051056 · Cited by 659
Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Butler, L. M., Perone, Y., Dehairs, J., Lupien, L. E., de Laat, V., Talebi, A., Loda, M., Kinlaw, W. B., & Swinnen, J. V. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.013 · Cited by 589
Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
Ackerman, D., & Simon, M. C. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.06.001 · Cited by 510
Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids
Zaidi, N., Lupien, L. E., Kuemmerle, N. B., Kinlaw, W. B., Swinnen, J. V., & Smans, K. A. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.08.005 · Cited by 480
Lipids in the tumor microenvironment: From cancer progression to treatment
Corn, K. C., Windham, M. A., & Rafat, M. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101055 · Cited by 486
Oxygen availability and metabolic adaptations
Nakazawa, M. S., Keith, B., & Simon, M. C. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.84 · Cited by 446
Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors
Lengyel, E. R., Makowski, L., DiGiovanni, J., & Kolonin, M. G. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.03.004 · Cited by 436
Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer
Liu, Q., Luo, Q., Halim, A., & Song, G. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.05.002 · Cited by 381
Lipid metabolism in cancer cells under metabolic stress
Munir, R., Lisec, J., Swinnen, J. V., & Zaidi, N. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0451-4 · Cited by 382
Biochemistry and pathophysiology of intravascular and intracellular lipolysisPreprint
Young, S. G., & Zechner, R. (2013) · Genes & Development · doi:10.1101/gad.209296.112 · Cited by 367
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N. L., Rebello, R. J., Porter, L. H., Niranjan, B., Whitby, S., Lo, J. C. Y., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau5758 · Cited by 332
Lipid metabolism and lipophagy in cancer
Maan, M., Peters, J. M., Dutta, M., & Patterson, A. D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.097 · Cited by 282
Metabolic reprogramming in triple-negative breast cancer
Wang, Z., Jiang, Q., & Dong, C. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0210 · Cited by 248
“TNBC exhibits enhanced lipid uptake by secreting lipoprotein lipase (LPL, which hydrolyzes the triglycerides in lipoproteins into fatty acids) and expressing CD36 (the channel for cellular fatty acid uptake) 83 .”
Background
Metabolic reprogramming in triple-negative breast cancer
Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243
CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway
Pan, J., Fan, Z., Wang, Z., Dai, Q., Xiang, Z., Yuan, F., Yan, M., Zhu, Z., Liu, B., & Li, C. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1049-7 · Cited by 244
Cancer metabolism at a glance
Vazquez, A., Kamphorst, J. J., Markert, E. K., Schug, Z. T., Tardito, S., & Gottlieb, E. (2016) · Journal of Cell Science · doi:10.1242/jcs.181016 · Cited by 225
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment
Fernández, L. P., de Cedrón, M. G., & de Molina, A. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.577420 · Cited by 234
Fatty acid metabolism in breast cancer subtypes
Monaco, M. E. (2017) · Oncotarget · doi:10.18632/oncotarget.15494 · Cited by 216
CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
Feng, W. W., Wilkins, O. M., Bang, S., Ung, M. H., Li, J., An, J., del Genio, C. L., Canfield, K., DiRenzo, J., Wells, W. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.008 · Cited by 214
Lipid metabolism in prostate cancer.
Wu, X., Daniels, G., Lee, P., & Monaco, M. E. (2014) · PubMed Central · Cited by 204
Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
Świerczyński, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i9.2279 · Cited by 203
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Nassar, Z. D., Mah, C. Y., Dehairs, J., Burvenich, I. J. G., Irani, S., Centenera, M. M., Helm, M., Shrestha, R. K., Moldovan, M. V., Don, A. S., et al. (2020) · eLife · doi:10.7554/elife.54166 · Cited by 199
Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers
Nath, A., & Chan, C. (2016) · Scientific Reports · doi:10.1038/srep18669 · Cited by 202
Exogenous lipids promote the growth of breast cancer cells via CD36
Zhao, J., Zheng, Z. P., Wang, C., Xing, H., Song, G., Yu, X., Zhu, Y., Wang, X., Zhang, X., & Di, Y. (2017) · Oncology Reports · doi:10.3892/or.2017.5864 · Cited by 191
Palmitic acid is an intracellular signaling molecule involved in disease development
Fatima, S., Hu, X., Gong, R., Huang, C., Chen, M., Wong, H. L. X., Bian, Z., & Kwan, H. Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03092-7 · Cited by 171
Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids
Louie, S. M., Roberts, L. S., Mulvihill, M. M., Luo, K., & Nomura, D. K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.008 · Cited by 154
Lipid accumulation and oxidation in glioblastoma multiforme
Taïb, B., Aboussalah, A. M., Moniruzzaman, M., Chen, S., Haughey, N. J., Kim, S. F., & Ahima, R. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-55985-z · Cited by 153
Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
Mondal, S., Roy, D., Bhattacharya, S. S., Jin, L., Jung, D., Zhang, S., Kalogera, E., Staub, J. K., Wang, Y., Xuyang, W., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31868 · Cited by 154
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts
Yao, C.-H., Fowle-Grider, R., Mahieu, N. G., Liu, G., Chen, Y., Wang, R., Singh, M., Potter, G. S., Gross, R. W., Schaefer, J., et al. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.03.007 · Cited by 142
Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment
Sormendi, S., & Wielockx, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00040 · Cited by 147
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
Robey, R. B., Weisz, J., Kuemmerle, N. B., Salzberg, A. C., Berg, A. S., Brown, D. G., Maurer, L. L., Palorini, R., Al‐Mulla, F., Al-Temaimi, R. A., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv037 · Cited by 143
The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
Agostini, M., Almeida, L. Y., Bastos, D. C., Ortega, R. M., Moreira, F. S., Seguin, F., Zecchin, K. G., Raposo, H. F., Oliveira, H. C. F., Amoêdo, N. D., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1136 · Cited by 131
Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer
Benjamin, D. I., Cravatt, B. F., & Nomura, D. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.013 · Cited by 131
Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings
Morciano, G., Marchi, S., Morganti, C., Sbano, L., Bittremieux, M., Kerkhofs, M., Corricelli, M., Danese, A., Karkucińska‐Więckowska, A., Wieckowski, M. R., et al. (2018) · Neoplasia · doi:10.1016/j.neo.2018.03.005 · Cited by 136
Fatty acid metabolism of immune cells: a new target of tumour immunotherapy
Zhang, S., Lv, K., Liu, Z., Zhao, R., & Li, F. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01807-9 · Cited by 141
Androgen control of lipid metabolism in prostate cancer: novel insights and future applications
Butler, L. M., Centenera, M. M., & Swinnen, J. V. (2016) · Endocrine Related Cancer · doi:10.1530/erc-15-0556 · Cited by 127
Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment
Daniëls, V. W., Smans, K. A., Royaux, I. E., Chypre, M., Swinnen, J. V., & Zaidi, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106913 · Cited by 119
Explaining decisions of graph convolutional neural networks: patient-specific molecular subnetworks responsible for metastasis prediction in breast cancer
Chereda, H., Bleckmann, A., Menck, K., Perera‐Bel, J., Stegmaier, P., Auer, F., Krämer, F., Leha, A., & Beißbarth, T. (2021) · Genome Medicine · doi:10.1186/s13073-021-00845-7 · Cited by 124
Signaling, metabolism, and cancer: An important relationship for therapeutic intervention
Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 126
Key Molecules of Fatty Acid Metabolism in Gastric Cancer
Li, C., Zhang, L., Qiu, Z., Deng, W., & Wang, W. (2022) · Biomolecules · doi:10.3390/biom12050706 · Cited by 119
Endothelial cell metabolism: parallels and divergences with cancer cell metabolism
Verdegem, D., Moens, S., Stapor, P. C., & Carmeliet, P. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-19 · Cited by 117
Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How
Bröer, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176156 · Cited by 116
Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans
Li, L., Che, L., Tharp, K. M., Park, H., Pilo, M. G., Cao, D., Cigliano, A., Latte, G., Xu, Z., Ribback, S., et al. (2016) · Hepatology · doi:10.1002/hep.28508 · Cited by 105
Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Zheng, Y., Zhou, R., Cai, J., Yang, N., Wen, Z., Zhang, Z., Sun, H., Huang, G., Guan, Y., Huang, N., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0025 · Cited by 105
The Lipid Metabolic Landscape of Cancers and New Therapeutic Perspectives
Wang, W., Bai, L., Li, W., & Cui, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.605154 · Cited by 106
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation
Ma, Y., Zha, J., Yang, X., Li, Q., Zhang, Q., Yin, A., Beharry, Z. M., Huang, H., Huang, J., Bartlett, M. G., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01667-y · Cited by 109
Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review
Ruze, R., Song, J., Yin, X., Chen, Y., Xu, R., Wang, C., & Zhao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01376-w · Cited by 111
Tumor-Induced Hyperlipidemia Contributes to Tumor Growth
Huang, J., Li, L., Lian, J., Schauer, S., Vesely, P. W., Kratky, D., Höefler, G., & Lehner, R. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.020 · Cited by 103
The Role of CD36 in Cancer Progression and Its Value as a Therapeutic Target
Feng, W. W., Zuppe, H. T., & Kurokawa, M. (2023) · Cells · doi:10.3390/cells12121605 · Cited by 104
Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem
Schwaiger-Haber, M., Stancliffe, E., Anbukumar, D. S., Sells, B. E., Yi, J., Cho, K., Adkins-Travis, K., Chheda, M. G., Shriver, L. P., & Patti, G. J. (2023) · Nature Communications · doi:10.1038/s41467-023-38403-x · Cited by 98
Mitochondrial and metabolic alterations in cancer cells
Gregorio, J. D., Petricca, S., Iorio, R., Toniato, E., & Flati, V. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151225 · Cited by 97
Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
Huang, J., Mondul, A. M., Weinstein, S. J., Koutros, S., Derkach, A., Karoly, E. D., Sampson, J. N., Moore, S. C., Berndt, S. I., & Albanes, D. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.305 · Cited by 88
Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
Tousignant, K. D., Rockstroh, A., Fard, A. T., Lehman, M., Wang, C., McPherson, S. J., Philp, L., Bartoniček, N., Dinger, M. E., Nelson, C. C., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-1147 · Cited by 85
Obesity and prostate cancer — microenvironmental roles of adipose tissue
Saha, A., Kolonin, M. G., & DiGiovanni, J. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00764-9 · Cited by 88
Lipid Heterogeneity Resulting from Fatty Acid Processing in the Human Breast Cancer Microenvironment Identified by GCIB-ToF-SIMS Imaging
Angerer, T. B., Magnusson, Y., Landberg, G., & Fletcher, J. S. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b03884 · Cited by 89
Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
Enciu, A., Radu, E., Popescu, I. D., Hinescu, M. E., & Ceafalan, L. C. (2018) · BioMed Research International · doi:10.1155/2018/7801202 · Cited by 84
The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective
Simões, I. C. M., Morciano, G., Lebiedzińska, M., Aguiari, G., Pinton, P., Potes, Y., & Wieckowski, M. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165834 · Cited by 84
Polyunsaturated fatty acid metabolism in prostate cancer
Berquin, I. M., Edwards, I. J., Kridel, S. J., & Chen, Y. Q. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9299-7 · Cited by 81
The Heterogeneity of Lipid Metabolism in Cancer
Park, J. K., Coffey, N. J., Limoges, A., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_3 · Cited by 80
Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing
Xu, J., Yu, T., Zois, C. E., Cheng, J., Tang, Y., Harris, A. L., & Huang, W. E. (2021) · Cancers · doi:10.3390/cancers13071718 · Cited by 78
Links between cancer metabolism and cisplatin resistance
Cocetta, V., Ragazzi, E., & Montopoli, M. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.01.005 · Cited by 77
Fatty acid metabolism and cancer development
Chen, Y., & Li, P. (2016) · 中国科学通报：英文版 · doi:10.1007/s11434-016-1129-4 · Cited by 73
Tumor microenvironmental nutrients, cellular responses, and cancer
Lobel, G. P., Jiang, Y., & Simon, M. C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.011 · Cited by 78
Clinical lipidomics in understanding of lung cancer: Opportunity and challenge
Zhang, L., Zhu, B., Zeng, Y., Shen, H., Zhang, J., & Wang, X. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.08.014 · Cited by 70
Endothelial cell metabolism and implications for cancer therapy
Harjes, U., Bensaad, K., & Harris, A. L. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.398 · Cited by 72
Metabolic signatures of human breast cancer
Mishra, P., & Ambs, S. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.992217 · Cited by 70
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells
Cao, D., Song, X., Che, L., Li, X.-L., Pilo, M., Vidili, G., Porcu, A., Solinas, A., Cigliano, A., Pes, G., et al. (2016) · Liver international (Print) · doi:10.1111/liv.13183 · Cited by 72
Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic OpportunitiesPreprint
Zadra, G., & Loda, M. F. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a030569 · Cited by 65
Milk fat components with potential anticancer activity—a review
Rodríguez-Alcalá, L. M., Castro-Gómez, M. P., Pimentel, L. L., & Fontecha, J. (2017) · Bioscience Reports · doi:10.1042/bsr20170705 · Cited by 72
Pathophysiology of Lipid Droplets in Neuroglia
Smolič, T., Zorec, R., & Vardjan, N. (2021) · Antioxidants · doi:10.3390/antiox11010022 · Cited by 71
Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms
Larkin, J. R., Anthony, S., Johanssen, V. A., Yeo, T., Sealey, M. A., Yates, A. G., Smith, C. F., Claridge, T. D. W., Nicholson, B. D., Moreland, J., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-2855 · Cited by 68
Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer
Dekker, Y., Dévédec, S. E. L., Danen, E. H. J., & Liu, Q. (2022) · Genes · doi:10.3390/genes13091585 · Cited by 66
Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
Rinaldi, G., Rossi, M., & Fendt, S. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1397 · Cited by 65
Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake
Wu, Z., Ma, H., Wang, L., Song, X., Zhang, J., Liu, W., Ge, Y., Sun, Y., Yu, X., Wang, Z., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0453-z · Cited by 63
To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway
Hsieh, Y.-C., Chen, Y.-M., Li, C.-Y., Chang, Y., Liang, S., Lin, S., Lin, C.-Y., Chang, S.-H., Wang, Y.-J., Khoo, K., et al. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.06.001 · Cited by 62
Chylomicrons stimulate incretin secretion in mouse and human cells
Psichas, A., Larraufie, P., Goldspink, D. A., Gribble, F. M., & Reimann, F. M. (2017) · Diabetologia · doi:10.1007/s00125-017-4420-2 · Cited by 58
Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered
Kinlaw, W. B., Baures, P. W., Lupien, L. E., Davis, W. L., & Kuemmerle, N. B. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25332 · Cited by 59
Persistent organic pollutants and obesity: are they potential mechanisms for breast cancer promotion?
Reaves, D. K., Ginsburg, E., Bang, J. J., & Fleming, J. M. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0411 · Cited by 61
Metabolic scavenging by cancer cells: when the going gets tough, the tough keep eating
Michalopoulou, E., Bulusu, V., & Kamphorst, J. J. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.256 · Cited by 59
Hepatocellular Carcinoma‐Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element‐Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth
Wang, C., Tong, Y., Wen, Y., Cai, J., Guo, H., Huang, L., Xu, M., Feng, M., Chen, X., Zhang, J., et al. (2018) · Hepatology · doi:10.1002/hep.30030 · Cited by 55
Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake
Aoki, T., Kinoshita, J., Munesue, S., Hamabe‐Horiike, T., Yamaguchi, T., Nakamura, Y., Okamoto, K., Moriyama, H., Nakamura, K., Harada, S., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12465-5 · Cited by 56
Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence
Bagwe‐Parab, S., Yadav, P., Kaur, G., Tuli, H. S., & Buttar, H. S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01100 · Cited by 54
Toward the Reliable Diagnosis of Indeterminate Thyroid Lesions: A HRMAS NMR-Based Metabolomics Case of Study
Torregrossa, L., Shintu, L., Chandran, J. N., Tintaru, A., Ugolini, C., Magalhães, A., Basolo, F., Miccoli, P., & Caldarelli, S. (2012) · Journal of Proteome Research · doi:10.1021/pr300105e · Cited by 53
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
Han, S., Mei, L., Quach, T., Porter, C. J. H., & Trevaskis, N. L. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03093-x · Cited by 54
A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue
McGowan, M. M., Eisenberg, B. L., Lewis, L. D., Froehlich, H. M., Wells, W. A., Eastman, A. R., Kuemmerle, N. B., Rosenkrantz, K. M., Barth, R. J., Schwartz, G. N., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2446-9 · Cited by 52
Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
Chakraborty, P. K., Xiong, X., Mustafi, S. B., Saha, S., Dhanasekaran, D. N., Mandal, N. A., McMeekin, S., Bhattacharya, R., & Mukherjee, P. (2015) · Oncotarget · doi:10.18632/oncotarget.5424 · Cited by 51
LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer
Cadenas, C., Vosbeck, S., Edlund, K., Grgas, K., Madjar, K., Hellwig, B., Adawy, A., Glotzbach, A., Stewart, J. D., Lesjak, M. S., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32138 · Cited by 56
Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment
Menard, J. A., Cerezo-Magaña, M., & Belting, M. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0480 · Cited by 50
Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity
Tiwary, S., Berzofsky, J. A., & Terabe, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02187 · Cited by 54
Prostate Cancer Progression: as a Matter of Fats
Scaglia, N., Frontini-López, Y. R., & Zadra, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.719865 · Cited by 52
Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases
Mauldin, I. S., Wages, N. A., Stowman, A. M., Wang, E., Smolkin, M. E., Olson, W. C., Deacon, D. H., Smith, K. T., Galeassi, N., Chianese‐Bullock, K. A., et al. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1881-y · Cited by 51
Diet and Pancreatic Cancer Prevention
Casari, I., & Falasca, M. (2015) · Cancers · doi:10.3390/cancers7040892 · Cited by 50
Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma
Lu, J., Zhang, Y., Sun, M., Ding, C., Zhang, L., Kong, Y., Cai, M., Miccoli, P., Ma, C., & Yue, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.737127 · Cited by 48
Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer
Ligorio, F., Pellegrini, I., Castagnoli, L., Vingiani, A., Lobefaro, R., Zattarin, E., Santamaria, M., Pupa, S. M., Pruneri, G., de Braud, F., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.04.023 · Cited by 49
Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer
Olea‐Flores, M., Juárez-Cruz, J. C., Catalán, M. A. M., Padilla‐Benavides, T., & Navarro‐Tito, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113493 · Cited by 48
Curcumin
Xiang, D., Zhang, K., Zeng, Y., Yan, Q.-Z., Shi, Z., Tuo, Q., Lin, L., Xia, B., Wu, P., & Liao, D.-F. (2020) · Medicine · doi:10.1097/md.0000000000018467 · Cited by 47
Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells
Lupien, L. E., Bloch, K. M., Dehairs, J., Traphagen, N. A., Feng, W. W., Davis, W. L., Dennis, T., Swinnen, J. V., Wells, W. A., Smits, N. C., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000327 · Cited by 46
Atypical plasma lipid profile in cancer patients: Cause or consequence?
Munir, R., Usman, H., Hasnain, S., Smans, K. A., Kalbacher, H., & Zaidi, N. (2014) · Biochimie · doi:10.1016/j.biochi.2014.03.010 · Cited by 45

Authors: Kuemmerle, N. B., Rysman, E., Lombardo, P. S., Flanagan, A. J., Lipe, B. C., Wells, W. A., Pettus, J. R., Froehlich, H. M., Memoli, V. A., Morganelli, P. M., Swinnen, J. V., Timmerman, L. A., Chaychi, L., Fricano, C. J., Eisenberg, B. L., Coleman, W. B., & Kinlaw, W. B.
Affiliations: Dartmouth–Hitchcock Medical Center (US)
University of North Carolina at Chapel Hill (US)
Corresponding author: Kinlaw, William B.
ORCID: Lombardo, Portia S.
Lipe, Brea C.
Wells, Wendy A.
Pettus, Jason R.
Swinnen, Johannes V.
Coleman, William B.
Kinlaw, William B.
Venue: Molecular Cancer Therapeutics
Publisher: American Association for Cancer Research (AACR)
Published: 2011-03-01
Volume: 10
Issue: 3
Pages: 427-436
ISSN: 1535-7163 (ISSN-L)
1538-8514
DOI: 10.1158/1535-7163.mct-10-0802
PMC: PMC3074101
OpenAlex: W2117594441
Cited by: 286
References: 46
Citations by year: 2026: 7 · 2025: 18 · 2024: 22 · 2023: 20 · 2022: 31 · 2021: 35 · 2020: 24 · 2019: 32 · 2018: 19 · 2017: 16 · 2016: 21 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 11
FWCI: 3.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Cancer Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: Howard Hughes Medical Institute (52005870)
Dartmouth College
Fonds Wetenschappelijk Onderzoek
Universität Ulm
Vlaamse regering
Norris Cotton Cancer Center
National Cancer Institute (R01CA126618, P50CA058207, P30CA023108)
National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007508, DK 07508)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: lipoprotein lipase, CD36, fatty acid uptake, dietary fat, solid tumor growth, lipolysis, triglyceride-rich lipoproteins, breast cancer, sarcoma, prostate cancer, fatty acid synthesis inhibition, cancer metabolism
MeSH terms: Animals, Dietary Fats, Fatty Acids, Female, Humans, Lipolysis, Lipoprotein Lipase, Liposarcoma, Male, Mice, Transgenic, Neoplasms, CD36 Antigens, Oligonucleotide Array Sequence Analysis, RNA, Small Interfering, Cell Line, Tumor, Cell Proliferation, Mice, Fatty Acid Synthesis Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks