Cancer metabolism at a glance
Open accessAbstract
A defining hallmark of cancer is uncontrolled cell proliferation. This is initiated once cells have accumulated alterations in signaling pathways that control metabolism and proliferation, wherein the metabolic alterations provide the energetic and anabolic demands of enhanced cell proliferation. How these metabolic requirements are satisfied depends, in part, on the tumor microenvironment, which determines the availability of nutrients and oxygen. In this Cell Science at a Glance paper and the accompanying poster, we summarize our current understanding of cancer metabolism, emphasizing pathways of nutrient utilization and metabolism that either appear or have been proven essential for cancer cells. We also review how this knowledge has contributed to the development of anticancer therapies that target cancer metabolism.
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Tumor cells chiefly require increased amounts of glucose and glutamine to survive.
“As a prominent feature of cell activation and proliferation, tumor cells chiefly require increased amounts of glucose and glutamine to survive (207).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [207]
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
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- Authors
- Vazquez, A., Kamphorst, J. J., Markert, E. K., Schug, Z. T., Tardito, S., & Gottlieb, E.
- Affiliations
- Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute 1 , Garscube Estate, Switchback Road, Glasgow G61 1BD , UK
- Cancer Research UK Scotland Institute (GB)
- Corresponding author
- Gottlieb, Eyal
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2016-09-15
- Volume
- 129
- Issue
- 18
- Pages
- 3367-3373
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- PMC
- PMC6518336
- OpenAlex
- W2519004842
- Cited by
- 225
- References
- 85
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 23 · 2023: 33 · 2022: 26 · 2021: 49 · 2020: 34 · 2019: 16 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Cell Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- cancer metabolism, tumor cell proliferation, tumor microenvironment, nutrient utilization, metabolic reprogramming, signaling pathways, oxygen availability
- MeSH terms
- Animals, Fatty Acids, Humans, Methylation, Neoplasms, Reactive Oxygen Species, Metabolic Networks and Pathways, Metabolome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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