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Cited by 160Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamicsChromosomal and Genetic Variations

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

The Loss of a Single Telomere Can Result in Instability of Multiple Chromosomes in a Human Tumor Cell Line

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Sabatier, Laure, Ricoul, Michelle, Pottier, Géraldine, Murnane, John P.·2005·Molecular Cancer Research
DOI 10.1158/1541-7786.mcr-04-0194
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Abstract

Spontaneous telomere loss has been proposed as an important mechanism for initiating the chromosome instability commonly found in cancer cells. We have previously shown that spontaneous telomere loss in a human cancer cell line initiates breakage/fusion/bridge (B/F/B) cycles that continue for many cell generations, resulting in DNA amplification and translocations on the chromosome that lost its telomere. We have now extended these studies to determine the effect of the loss of a single telomere on the stability of other chromosomes. Our study showed that telomere acquisition during B/F/B cycles occurred mainly through translocations involving either the nonreciprocal transfer or duplication of the arms of other chromosomes. Telomere acquisition also occurred through small duplications involving the subtelomeric region of the other end of the same chromosome. Although all of these mechanisms stabilized the chromosome that lost its telomere, they differed in their consequences for the stability of the genome as a whole. Telomere acquisition involving nonreciprocal translocations resulted in the loss of a telomere on the donor chromosome, which consequently underwent additional translocations, isochromosome formation, or complete loss. In contrast, telomere acquisition involving duplications stabilized the genome, although the large duplications created substantial allelic imbalances. Thus, the loss of a single telomere can generate a variety of chromosome alterations commonly associated with human cancer, not only on a chromosome that loses its telomere but also on other chromosomes. Factors promoting telomere loss are therefore likely to have an important role in generating the karyotype evolution associated with human cancer.

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Crossref · 10.1158/1541-7786.mcr-04-0194

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  • Telomere loss at individual chromosome ends is sufficient to produce many rearrangements seen in telomere crisis and cancer, including amplifications, LOH, translocations, chromosome non-disjunction, and formation of isochromosomes and ring chromosomes.

    “Telomere loss at individual chromosome ends is sufficient to produce many of the rearrangements seen in telomere crisis and in cancer, including amplifications, LOH, translocations, chromosome non-disjunction during mitosis, and the formation of isochromosomes and ring chromosomes170,172.”

    From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [172]

  • Even limited telomere dysfunction can cause widespread genome instability because instability at individual chromosome ends can transfer to other chromosomes through non-reciprocal translocations.

    “Even limited telomere dysfunction can wreak havoc on the genome because instability at individual chromosome ends can be transferred to other chromosomes through non-reciprocal translocations172,173.”

    From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [172]

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Metadata

Authors
Sabatier, L., Ricoul, M., Pottier, G., & Murnane, J. P.
Affiliations
  • Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
  • 1Laboratoire de Radiobiologie et Oncologie, Commissariat à l'Energie Atomique, Fontenay-aux Roses, France and
  • University of California, San Francisco (US)
ORCID
Venue
Molecular Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2005-03-01
Volume
3
Issue
3
Pages
139-150
ISSN
  • 1541-7786 (ISSN-L)
  • 1557-3125
DOI
10.1158/1541-7786.mcr-04-0194
OpenAlex
W2141834347
Cited by
160
References
15
Citations by year
2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 9
FWCI
8.99
Type
journal article
Language
en
Open access
Locations
  • Molecular Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01CA069044, R01 CA69044)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords
telomere loss, chromosomal instability, breakage-fusion-bridge cycles, non-reciprocal translocation, chromosome duplication, allelic imbalance, karyotype evolution, cancer, human cancer cell lines
MeSH terms
Alleles, Chromosome Mapping, Chromosomes, DNA, Humans, Karyotyping, Models, Biological, Models, Genetic, Plasmids, Translocation, Genetic, Telomere, Genome, Gene Duplication, DNA Sequence, Unstable, Cell Line, Tumor

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