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Monitoring autophagy in cancer: From bench to bedside

Long, Maeve, McWilliams, Thomas G.·2020·Seminars in Cancer Biology
DOI 10.1016/j.semcancer.2019.05.016
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Abstract

Autophagy refers to an essential mechanism that evolved to sustain eukaryotic homeostasis and metabolism during instances of nutrient deprivation. During autophagy, intracellular cargo is encapsulated and delivered to the lysosome for elimination. Loss of basal autophagy in vivo negatively impacts cellular proteostasis, metabolism and tissue integrity. Accordingly, many drug development strategies are focused on modulating autophagic capacity in various pathophysiological states, from cancer to neurodegenerative disease. The role of autophagy in cancer is particularly complicated, as either augmenting or attenuating this process can have variable outcomes on cellular survival, proliferation and transformation. This complexity is compounded by the emergence of several selective autophagy pathways, which act to eliminate damaged or superfluous cellular components in a targeted fashion. The advent of sensitive tools to monitor autophagy pathways in vivo holds promise to clarify their importance in cancer pathophysiology. In this review, we provide an overview of autophagy in cancer biology and outline how the development of tools to study autophagy in vivo could enhance our understanding of its function for translational benefit.

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Metadata

Authors
Long, M., & McWilliams, T. G.
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2020-11
Volume
66
Pages
12-21
ISSN
1044-579X
DOI
10.1016/j.semcancer.2019.05.016
Cited by
30
References
26
Language
en
Licence
Funders
  • Sigrid Juséliuksen Säätiö
  • Novo Nordisk Fonden
  • Helsingin Yliopisto
  • Academy of Finland

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