The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy
Open accessAbstract
Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and survival while subject to changes in environmental cues. Thus, a vital component of a cancer cell lies in its metabolic adaptability. The constant demand for metabolic alterations requires flexibility, that is, the ability to utilize different metabolic substrates; as well as plasticity, that is, the ability to process metabolic substrates in different ways. In this review, we discuss how dynamic changes in cancer metabolism affect tumor progression and the consequential implications for cancer therapy. Significance: Recognizing cancer dynamic metabolic adaptability as an entity can lead to targeted therapy that is expected to decrease drug resistance.
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1 retracted
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Altered metabolism in cancer: insights into energy pathways and therapeutic targets
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Mitochondrial RNA modifications shape metabolic plasticity in metastasis
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Regulatory mechanisms of one-carbon metabolism enzymes
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Metadata
- Authors
- Fendt, S.-M., Frezza, C., & Erez, A.
- Venue
- Cancer Discovery
- Published
- 2020-12-01
- Volume
- 10
- Issue
- 12
- Pages
- 1797-1807
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W3095331736
- Cited by
- 313
- References
- 105
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
