Senile Dementia of the Neurofibrillary Tangle Type: A Comparison with Alzheimer’s Disease

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

Gómez‐Isla, T., Hollister, R., West, H., Mui, S., Growdon, J. H., Petersen, R. C., Parisi, J. E., & Hyman, B. T. (1997) · Annals of Neurology · doi:10.1002/ana.410410106 · Cited by 1,489 · see citing works

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · see citing works

Tau is a candidate gene for chromosome 17 frontotemporal dementia

Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · see citing works

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · see citing works

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

Mori, H., Kondo, J., & Ihara, Y. (1987) · Science · doi:10.1126/science.3029875 · Cited by 843 · see citing works

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.

Mori, H., Takio, K., OGAWARA, M., & Selkoe, D. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41896-0 · Cited by 481 · see citing works

Genetic evidence for the involvement of τ in progressive supranuclear palsy

Conrad, C., Andreadis, A., Trojanowski, J. Q., Dickson, D. W., Kang, D. E., Chen, X., Wiederholt, W. C., Hansen, L., Masliah, E., Thal, L. J., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410410222 · Cited by 388 · see citing works

Neurons May Live for Decades with Neurofibrillary Tangles

Morsch, R., Simon, W., & Coleman, P. D. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199902000-00008 · Cited by 370 · see citing works

Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

Spillantini, M. G., Crowther, R. A., Kamphorst, W., Heutink, P., & Swieten, J. C. V. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65721-5 · Cited by 293 · see citing works

Tau Pathology in a Family with Dementia and a P301L Mutation in Tau

Mirra, S. S., Murrell, J. R., Gearing, M., Spillantini, M. G., Goedert, M., Crowther, R. A., Levey, A. I., Jones, R., Green, J., Shoffner, J. M., et al. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199904000-00004 · Cited by 191 · see citing works

Tau gene mutation in familial progressive subcortical gliosis

Goedert, M., Spillantini, M. G., Crowther, R. A., Chen, S. G., Parchi, P., Tabaton, M., Lanska, D. J., Markesbery, W. R., Wilhelmsen, K. C., Dickson, D. W., et al. (1999) · Nature Medicine · doi:10.1038/7454 · Cited by 187 · see citing works

Intracellular APP Processing and Aβ Production in Alzheimer Disease

Wilson, C., Doms, R. W., & Lee, V. M. ‐. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00001 · Cited by 187 · see citing works

Autosomal dominant dementia with widespread neurofibrillary tangles

Reed, L. A., Schelper, R. L., Solodkin, A., Hoesen, G. W. V., Hoesen, G. W. V., Solodkin, A., Morris, J. C., Trojanowski, J. Q., Grabowski, T. J., Talbot, C. J., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410420406 · Cited by 181 · see citing works

Senile Dementia with Tangles (Tangle Predominant Form of Senile Dementia)

Jellinger, K. A., & Bancher, C. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00160.x · Cited by 148 · see citing works

Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects

Bancher, C., & Jellinger, K. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00296494 · Cited by 115 · see citing works

The tau gene A0 polymorphism in progressive supranuclear palsy and related neurodegenerative diseases

Morris, H. R., Janssen, J. C., Bandmann, O., Daniel, S. E., Rossor, M. N., Lees, A. J., & Wood, N. W. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.5.665 · Cited by 107 · see citing works

Progressive supranuclear gaze palsy is in linkage disequilibrium with theτ and not the α-synuclein gene

Higgins, J. J., Litvan, I., Pho, L. T., Li, W., & Nee, L. E. (1998) · Neurology · doi:10.1212/wnl.50.1.270 · Cited by 89 · see citing works

Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease

Fukutani, Y., Kobayashi, K., Nakamura, I., Watanabe, K., Isaki, K., & Cairns, N. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12083-g · Cited by 88 · see citing works

Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease.

Endoh, R., Ogawara, M., Iwatsubo, T., Nakano, I., & Mori, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91707-y · Cited by 87 · see citing works

Direct genetic evidence for involvement of tau in progressive supranuclear palsy

Bennett, P., Bonifati, V., Bonuccelli, U., Colosimo, C., Mari, M. D., Fabbrini, G., Marconi, R., Meco, G., Nicholl, D. J., Stocchi, F., et al. (1998) · Neurology · doi:10.1212/wnl.51.4.982 · Cited by 86 · see citing works

Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia

ULRICH, J. (1992) · Neurodegeneration · Cited by 76 · see citing works

Low prevalence of apolipoprotein E ε4 allele in the neurofibrillary tangle predominant form of senile dementia

Bancher, C., Egensperger, R., Kösel, S., Jellinger, K. A., & Graeber, M. B. (1997) · Acta Neuropathologica · doi:10.1007/s004010050726 · Cited by 71 · see citing works

A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele

Ikeda, K., Akiyama, H., Arai, T., Sahara, N., Mori, H., Usami, M., Sakata, M., Mizutani, T., Wakabayashi, K., & Takahashi, H. (1997) · Annals of Neurology · doi:10.1002/ana.410410522 · Cited by 55 · see citing works

Ki-M1P as a marker for microglia and brain macrophages in routinely processed human tissues

Paulus, W., Roggendorf, W., & Kirchuer, T. (1992) · Acta Neuropathologica · doi:10.1007/bf00304473 · Cited by 52 · see citing works

Dementia of the Alzheimer type and related dementias in the aged: DAT subgroups and senile dementia of the neurofibrillary tangle type

Yamada, M., Itoh, Y., Otomo, E., Suematsu, N., & Matsushita, M. (1996) · Neuropathology · doi:10.1111/j.1440-1789.1996.tb00162.x · Cited by 47 · see citing works

An immunohistochemical study of centenarian brains: a comparison

Itoh, Y., Yamada, M., Suematsu, N., Matsushita, M., & Otomo, E. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00050-1 · Cited by 45 · see citing works

Clinical Aspects of ‘Senile Dementia of the Tangle Type’ – A Subset of Dementia in the Senium Separable from Late-Onset Alzheimer’s Disease

Ikeda, K., Akiyama, H., Arai, T., Oda, T., Kato, M., Iseki, E., Kosaka, K., Wakabayashi, K., & Takahashi, H. (1998) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017091 · Cited by 39 · see citing works

The Tauopathies

Goedert, M., & Hasegawa, M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65242-x · Cited by 37 · see citing works

Usefulness of Simple Measures of Temporal Lobe Atrophy in Probable Alzheimer's Disease

Frisoni, G. B., Beltramello, A., Weiss, C., Geroldi, C., Bianchetti, A., & Trabucchi, M. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106847 · Cited by 27 · see citing works

Dementia Characterized by Abundant Neurofibrillary Tangles and Scarce Senile Plaques: A Quantitative Pathological Study

Itoh, Y., Yamada, M., Yoshida, R., Suematsu, N., Oka, T., Matsushita, M., & Otomo, E. (2008) · European Neurology · doi:10.1159/000117216 · Cited by 24 · see citing works

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works

Primary age-related tauopathy (PART): a common pathology associated with human aging

Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · see citing works

The neuropathology of probable Alzheimer disease and mild cognitive impairment

Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935 · see citing works

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

Hopperton, K. E., Mohammad, D., Trépanier, M. O., Giuliano, V, & Bazinet, R. P. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.246 · Cited by 567 · see citing works

Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes

Omalu, B., Bailes, J., Hamilton, R. L., Kamboh, M. I., Hammers, J., Case, M., & Fitzsimmons, R. (2011) · Neurosurgery · doi:10.1227/neu.0b013e318212bc7b · Cited by 381 · see citing works

Meta‐analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

de Wilde, M. C., Overk, C., Sijben, J., & Masliah, E. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.12.005 · Cited by 273 · see citing works

Chronic traumatic encephalopathy (CTE) in a National Football League Player

Omalu, B. I., Hamilton, R. L., Kamboh, M. I., DeKosky, S. T., & Bailes, J. E. (2010) · Journal of Forensic Nursing · doi:10.1111/j.1939-3938.2009.01064.x · Cited by 260 · see citing works

Tau PET Imaging in Alzheimer’s Disease

Okamura, N., Harada, R., Furumoto, S., Arai, H., Yanai, K., & Kudo, Y. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0500-6 · Cited by 169 · see citing works

Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0156-7 · Cited by 157 · see citing works

Tau imaging in neurodegenerative diseases

Dani, M., Brooks, D. J., & Edison, P. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3231-2 · Cited by 125 · see citing works

Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease

Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Santacruz, K., Smith, C. D., Patel, E., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181aacbe9 · Cited by 115 · see citing works

Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*

Yamada, M. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00522.x · Cited by 99 · see citing works

The MAPT H1 haplotype is associated with tangle-predominant dementia

Santa‐María, I., Haggiagi, A. M., Liu, X., Wasserscheid, J., Nelson, P. T., Dewar, K., Clark, L. N., & Crary, J. F. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1017-1 · Cited by 83 · see citing works

Quantitative analysis of neurofibrillary pathology in a general population to reappraise neuropathological criteria for senile dementia of the neurofibrillary tangle type (tangle‐only dementia): The Hisayama study

Noda, K., Sasaki, K., Fujimi, K., Wakisaka, Y., Tanizaki, Y., Wakugawa, Y., Kiyohara, Y., Iida, M., Aizawa, H., & Iwaki, T. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00722.x · Cited by 49 · see citing works

Suspected non-Alzheimer's pathology – Is it non-Alzheimer's or non-amyloid?

Dani, M., Brooks, D. J., & Edison, P. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.02.003 · Cited by 48 · see citing works

Tau accumulation in the nucleus accumbens in tangle-predominant dementia

Kawakami, I., Hasegawa, M., Arai, T., Ikeda, K., Oshima, K., Niizato, K., Aoki, N., Omi, K., Higashi, S., Hosokawa, M., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-40 · Cited by 41 · see citing works

Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia

Iseki, E., Yamamoto, R., Murayama, N., Minegishi, M., Togo, T., Katsuse, O., Kosaka, K., Akiyama, H., Tsuchiya, K., Rohan, D. S., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.036 · Cited by 39 · see citing works

Primary age-related tauopathy

Richardson, T. E., Walker, J. M., Farrell, K. W., Oliveira, T. G., White, C. L., & Crary, J. F. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02943-x · Cited by 21 · see citing works

The Pathology of Paraphrenia

Casanova, M. F. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0108-8 · Cited by 15 · see citing works

Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations

Sudo, S., Shiozawa, M., Cairns, N. J., & Wada, Y. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.043 · Cited by 14 · see citing works

Relationship between microtubule-binding repeats and morphology of neurofibrillary tangle in Alzheimer's disease

Kitamura, T., Sugimori, K., Sudo, S., & Kobayashi, K. (2005) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2005.00488.x · Cited by 14 · see citing works

Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study

Hamasaki, H., Honda, H., Okamoto, T., Koyama, S., Suzuki, S. O., Ohara, T., Ninomiya, T., Kiyohara, Y., & Iwaki, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160521 · Cited by 14 · see citing works

Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia

Kikukawa, T., Abe, T., Ataka, S., Saito, H., Hasegawa, I., Mino, T., Takeuchi, J., Kawabe, J., Wada, Y., Watanabe, Y., et al. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3477-0 · Cited by 10 · see citing works

Apolipoprotein E genotype in senile dementia with tangles differs from Alzheimer's disease

Tolnay, M., Villoz, N., Probst, A., & Miserez, A. R. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2003.04032.x · Cited by 9 · see citing works

Effects of aging on behavioral symptoms in Alzheimer's disease

Konishi, K., Hori, K., Oda, T., Tominaga, I., Asaoka, T., Hachisu, M., & Shibasaki, T. (2009) · Psychogeriatrics · doi:10.1111/j.1479-8301.2009.00267.x · Cited by 9 · see citing works

Macroscopic findings of brain with dementia

Hashizume, Y. (2022) · Neuropathology · doi:10.1111/neup.12785 · Cited by 7 · see citing works

Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: A longitudinal study

Li, J., Song, J., John Suckling, A., Wang, Y., Zuo, C., Zhang, C. M., Gao, J., Song, Y., Xie, A., Tan, L., et al. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.11.002 · Cited by 6 · see citing works

Historical review of academic concepts of dementia in the world and Japan: with a short history of representative diseases

Fukui, T. (2014) · Neurocase · doi:10.1080/13554794.2014.894532 · Cited by 3 · see citing works

Senile dementia of the neurofibrillary tangle type (SD-NFT): a clinical, neuropathological and molecular genetic study

Yamada, M., Itoh, Y., Sodeyama, N., Suematsu, N., Otomo, E., Matsushita, M., & Mizusawa, H. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8225-5_11 · Cited by 3 · see citing works

Protein Misfolding, Neurodegeneration and Tau

Seneci, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800186-8.00001-8 · Cited by 2 · see citing works

Dementias

Ellison, D., Love, S., Chimelli, L. M. C., Harding, B. N., Lowe, J. S., Vinters, H. V., Brandner, S., & Yong, W. H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-7234-3515-0.00031-3 · Cited by 1 · see citing works

Disease trajectories in elders with suspected non-Alzheimer’s pathophysiology and its comparison with Alzheimer’s disease pathophysiology: a longitudinal studyPreprint

Li, J., Song, J., John Suckling, A., Wang, Y., Zuo, C., Zhang, C. M., Gao, J., Song, Y., Xie, A., Tan, L., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2744271/v1 · Cited by 1 · see citing works

Tau PET in Neurodegenerative Diseases Manifesting Dementia

Okamura, N., Harada, R., Furumoto, S., & Kudo, Y. (2017) · Springer eBooks · doi:10.1007/978-4-431-55133-1_10

Déterminants structuraux d’agrégats de Tau distincts : vers de nouveaux outils moléculaires pour discriminer les tauopathies

Caroux, E. (2019) · theses.fr (ABES) · doi:10.70675/35d706bfz0d1bz440ezac4bz7fd4138464f8

Clinical characteristics of “Kobe dementia model” of Alzheimer’s disease with diabetes mellitus in Kobe City

Yoshino, H., Okumura, T., Kawakami, K., Ota, S., Yoshino, G., & Takechi, H. (2026) · Aging Medicine and Healthcare · doi:10.4103/amah.amh-2024-11-117

Senile dementia of the neurofibrillary tangle type (SD-NFT): a clinical, neuropathological and molecular genetic study

Yamada, M., Itoh, Y., Sodeyama, N., Suematsu, N., Otomo, E., Matsushita, M., & Mizusawa, H. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8225-5_11 · Cited by 3 · see citing works

Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*

Yamada, M. (2003) · Neuropathology · doi:10.1046/j.1440-1789.2003.00522.x · Cited by 99 · see citing works

Hippocampal sclerosis in senile dementia of the neurofibrillary tangle type

Tahara, N., Tahara, D., Akagi, A., Riku, Y., Sone, J., Miyahara, H., Nagai, A., Yoshida, M., & Iwasaki, Y. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123437 · Cited by 2 · see citing works

Dementia of the Alzheimer type and related dementias in the aged: DAT subgroups and senile dementia of the neurofibrillary tangle type

Yamada, M., Itoh, Y., Otomo, E., Suematsu, N., & Matsushita, M. (1996) · Neuropathology · doi:10.1111/j.1440-1789.1996.tb00162.x · Cited by 47 · see citing works

[Senile Dementia of the Neurofibrillary Tangle Type (SD-NFT)].

Yamada, M. (2018) · PubMed · doi:10.11477/mf.1416201035 · Cited by 3 · see citing works