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Cited by 39Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia

Iseki, Eizo, Yamamoto, Ryoko, Murayama, Norio, Minegishi, Michiko, Togo, Takashi, Katsuse, Omi, Kosaka, Kenji, Akiyama, Haruhiko +4 more·2006·Neuroscience Letters
DOI 10.1016/j.neulet.2006.06.036
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Abstract

Limbic neurofibrillary tangle dementia (LNTD) is a subset of senile dementia characterized by numerous neurofibrillary tangles (NFT) in the hippocampal area, although there is an absence or scarcity of amyloid deposits (AM) throughout the brain. In the present study, we immunohistochemically investigated regional numbers and tau isoforms of NFT in the hippocampal area of nine LNTD patients with anti-three-repeat (3R) tau-specific and anti-four-repeat (4R) tau-specific antibodies, differentiating NFT into three developmental stages of pretangles (PT), NFT and ghost tangles (GT). Consequently, most PT were 4R tau-positive, most GT were 3R tau-positive, and NFT were 3R tau-, 4R tau- or double-positive, suggesting that composition of tau isoforms may shift from a 4R tau-predominant pattern to a 3R tau-predominant pattern during the development of NFT. In addition, a large number of NFT showing different developmental stages and different rates of 3R tau- and 4R tau-positive neurons according to the region were found in the hippocampal area, suggesting that regions undergoing earlier NFT formation may show higher ratio of 3R tau-positive neurons to 4R tau-positive neurons, and that NFT formation may begin in the entorhinal and transentorhinal cortices, subsequently progress to the subiculum and CA1, and further to the CA2, amygdala and CA3-4, although progression to the neocortex is limited. Furthermore, 4R tau-positive astrocytes and grains were found in several patients, suggesting that LNTD is a form of tauopathy.

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  • Neurofibrillary tangles in ECII neurons have been shown to be devoid of 4R-tau, in contrast to NFTs in other hippocampal neurons that have both tau isoforms.

    “Importantly, NFTs in ECII neurons have been shown to be devoid of 4R-tau, in contrast to NFTs in other hippocampal neurons that have both tau isoforms (Hara et al., 2013; Iseki et al., 2006).”

    From Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis (2020) · cites this paper as Iseki et al., 2006

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Authors
Iseki, E., Yamamoto, R., Murayama, N., Minegishi, M., Togo, T., Katsuse, O., Kosaka, K., Akiyama, H., Tsuchiya, K., Rohan, D. S., Andrew, L., & Arai, H.
Affiliations
  • Juntendo University (JP)
  • Yokohama City University (JP)
  • Tokyo Institute of Psychiatry (JP)
  • Tokyo Metropolitan Matsuzawa Hospital (JP)
Corresponding author
Iseki, Eizo
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2006-09
Volume
405
Issue
1-2
Pages
29-33
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2006.06.036
OpenAlex
W2042847553
Cited by
39
References
19
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neurofibrillary tangles, tau isoforms, 3R tau, 4R tau, hippocampus, tauopathy, entorhinal cortex, subiculum, CA1, amygdala, senile dementia
MeSH terms
Aged, 80 and over, Dementia, Female, Hippocampus, Humans, Immunohistochemistry, Male, Neurofibrillary Tangles, tau Proteins, Protein Isoforms

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