The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks
Abstract
The development of novel treatments for Alzheimer’s disease (AD), aimed at ameliorating symptoms and modifying disease processes, increases the need for early diagnosis. Neuropsychological deficits such as poor episodic memory are a consistent feature of early-in-the-course AD, but they overlap with the cognitive impairments in other disorders such as depression, making differential diagnosis difficult. Computerised and traditional tests of memory, attention and executive function were given to four subject groups: mild AD (n = 26); questionable dementia (QD; n = 43); major depression (n = 37) and healthy controls (n = 39). A visuo-spatial associative learning test accurately distinguished AD from depressed/control subjects and revealed an apparent sub-group of QD patients who performed like AD patients. QD patients’ performance correlated with the degree of subsequent global cognitive decline. Elements of contextual and cued recall may account for the task’s sensitivity and specificity for AD.
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“Second, depression occurs more frequently in people with diabetes [73] and is difficult to differentiate clinically from dementia and early cognitive decline [74 -77].”
From Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies (2005) · cites this paper as [74]
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- 10.1037//0894-4105.9.1.126 · DOI
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Cognitive impairment in depression: a systematic review and meta-analysis
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014) · Psychological Medicine · doi:10.1017/s0033291713002535 · Cited by 2,161
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Cognitive decline and dementia in diabetes—systematic overview of prospective observational studies
Cukierman, T., Gerstein, H. C., & Williamson, J. D. (2005) · Diabetologia · doi:10.1007/s00125-005-0023-4 · Cited by 1,049
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Metadata
- Authors
- Swainson, R., Hodges, J. R., Galton, C. J., Semple, J., Michael, A., Dunn, B. D., Iddon, J. L., Robbins, T. W., & Sahakian, B. J.
- Affiliations
- University of Cambridge (GB)
- Addenbrooke's Hospital (GB)
- West Suffolk Hospital (GB)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2001
- Volume
- 12
- Issue
- 4
- Pages
- 265-280
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W1980584599
- Cited by
- 375
- References
- 65
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 14 · 2019: 17 · 2018: 12 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 18
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- Alzheimer's disease, depression, differential diagnosis, early detection, episodic memory, cognitive decline, cued recall, neuropsychological assessment
- MeSH terms
- Aged, Alzheimer Disease, Analysis of Variance, Dementia, Major Depressive Disorder, Diagnosis, Differential, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Logistic Models, Case-Control Studies
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