Stimulation of the Human Cytomegalovirus IE Enhancer/Promoter in HL-60 Cells by TNFα Is Mediated via Induction of NF-κB
Open accessAbstract
TNFalpha enhances the basal activity of the major Immediate Early (IE) enhancer/promoter of human cytomegalovirus (HCMV) in the immature premonocytic HL-60 cell line. The stimulatory effect of TNFalpha is mediated by induction of the transcription factor NF-kappaB, which specifically binds to the 18-bp repetitive sequence motif of the enhancer region. Complex formation could be competed by oligonucleotides representing the 18-bp sequence motif or the prototype NF-kappaB sequence of the immunoglobulin kappa gene. In gel mobility shift assays antisera specific to NF-kappaB p50 and p65 subunits were shown to react with the DNA-protein complex. Addition of the antioxidant PDTC blocked TNFalpha-mediated stimulation in a dose dependent manner. Electrophoretic mobility shift assays indicated that PDTC prevents NF-kappaB induction. Furthermore, it is suggested that protein kinases like PK-C are involved in the TNFalpha signal transduction pathway which leads to the activation of NF-kappaB and its binding to the HCMV IE enhancer in HL-60 cells. Our data are consistent with a role of TNFalpha in reactivation of latent HCMV infection in premonocytic cells.
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If antioxidant molecules are depleted in T cells, cytokine production can become uncontrolled, potentially resulting in an inflammatory environment that is known to reactivate CMV.
“Finally, if antioxidant molecules are depleted in T cells, then cytokine production, can become uncontrolled (Michalek et al. 2012), potentially resulting in an inflammatory environment that is also known to reactivate CMV (Docke et al. 1994; Prosch et al. 1995; Stein et al. 1993).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Prosch et al. 1995
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“In a first approach we could demonstrate that the antioxidant PDTC is able to block TNFα stimulation of the IE1/2 enhancer/promoter in HL-60 cells (Prösch et al., 1995).”
BackgroundMethodInfluentialSelf-citationRICK Activates a NF-κB-dependent Anti-human Cytomegalovirus Response
Eickhoff, J., Hanke, M., Stein-Gerlach, M., Kiang, T. P., Herzberger, K., Habenberger, P., Müller, S., Klebl, B., Marschall, M., Stamminger, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312893200 · Cited by 35 · see citing works
Self-citationAiba-Masago, S., Baba, S., Li, R.-Y., Shinmura, Y., Kosugi, I., Arai, Y., Nishimura, M., & Tsutsui, Y. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65320-5 · Cited by 34 · see citing works
Gredmark, S., Britt, W., Xie, X., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4897 · Cited by 33 · see citing works
Pentoxifylline Promotes Replication of Human Cytomegalovirus In Vivo and In Vitro
Staak, K., Prösch, S., Stein, J., et al. (1997) · Blood · doi:10.1182/blood.v89.10.3682 · Cited by 33 · see citing works
Self-citationNogalski, M. T., Podduturi, J. P., DeMeritt, I. B., Milford, L. E., & Yurochko, A. D. (2007) · Journal of Virology · doi:10.1128/jvi.02382-06 · Cited by 31 · see citing works
Gredmark‐Russ, S., & Söderberg‐Nauclér, C. (2012) · Virulence · doi:10.4161/viru.22239 · Cited by 30 · see citing works
Dukay, B., Walter, F. R., Vigh, J. P., Barabási, B., Hajdu, P., Balassa, T., Migh, E., Kincses, A., Hoyk, Z., Szögi, T., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02070-2 · Cited by 28 · see citing works
Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?
Söderberg‐Nauclér, C., Fornara, O., & Rahbar, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.06.005 · Cited by 30 · see citing works
Heller, L. C., Cruz, Y., Ferraro, B., et al. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.43 · Cited by 30 · see citing works
- Authors
- Prösch, S., Staak, K., Stein, J., Liebenthal, C., Stamminger, T., Volk, H.-D., & Krüger, D. H.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 208
- Issue
- 1
- Pages
- 197-206
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2046219854
- Cited by
- 188
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- human cytomegalovirus, TNF-α, NF-κB, HL-60 cells, latent viral reactivation, pyrrolidine dithiocarbamate, protein kinase C, signal transduction, transcriptional activation
- MeSH terms
- Antigens, Viral, Cytomegalovirus Infections, Cytomegalovirus, Dose-Response Relationship, Drug, Humans, Tumor Necrosis Factor-alpha, Virus Replication, Signal Transduction, NF-kappa B, Immediate-Early Proteins, HL-60 Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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